...Z. Krištofiková; O. Benešová; H. Tejkalová The effect of tacrine (THA), the cholinesterase inhibitor, and Ginkgo biloba extract (EGb) on the sodium-dependent high-affinity choline uptake (HACU) into hippocampal synaptosomes was studies in vivo in model experiments after long-term administration...

...Norman L. Foster; Ronald C. Peterson; Stephen I. Gracon; Karen Lewis We studied the effects of 40 and 80 mg/day of tacrine on patients with probable Alzheimer''s disease (AD) in an 8-week, randomized, double-blind, placebo-controlled crossover trial with an enriched-population design...

...Monika Johansson; Ewa Hellström-Lindahl; Agneta Nordberg The pharmacokinetics of the cholinesterase inhibitor tacrine was studied in 5 Alzheimer patients during 12–31 months of treatment. A mean average steady-state concentration in plasma ranging from 1.1 to 30ng/ml was obtained with doses ranging...

...L. Minthon; N. Nilsson; L. Edvinsson; P.E. Wendt; L. Gustafson Regional cerebral blood flow (rCBF) was studied in patients with Alzheimer''s disease (AD) before and after 14 months of tacrine treatment. The treated group was compared with an identical reference group of untreated AD patients...

.... The most consistent neurochemical changes in DAT are reductions in the cholinergic system. The major pharmacological approach today in DAT is based on the cholinergic theory assuming that acetylcholine has a major cortical impact on cognitive processes. Tetrahydroaminoacridine (THA, tacrine) is a centrally...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Tacrine Tetrahydroaminoacridine Alzheimer's disease Regional cerebral blood flow Quantified EEG Original Research...

... have examined the results of a recently reported clinical trial of tacrine. For this purpose we have analysed the first half of our cross-over trial as a parallel group study involving 73 patients. The previously reported significant changes in MMSE in drug versus placebo groups was held up...