Twenty-two patients suffering from mild to moderate dementia of vascular origin were treated with vinpocetine, 30 mg/day during 16 weeks, in an open pilot study. Response to treatment was assessed with the Gottfries-BrÅne-Steen geriatric rating scale and psychometric tests. Effects on concentrations of neurotransmitters in the cerebrospinal fluid (CSF) and on the blood-brain barrier function were also studied. According to the ratings and tests, the only noticeable improvement was reduced fear/panic. This improvement may very well be attributable to increased care of the patients during the study. The drug did not influence the monoamine metabolites in the CSF or the blood-brain barrier function. On the basis of these results we conclude that vinpocetine has no effect on patients suffering from mild to moderate dementia of vascular origin.

Keywords:
Multi-infarct dementia, Gottfries-Bråne-Steen scale, Monoamine metabolites, Blood-brain barrier
This content is only available via PDF.
© 1990 S. Karger AG, Basel
1990
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.