Areas of pedunculopontine nuclei (PPN) of rats were Iesioned bilaterally by local injection of ibotenic acid. The medial thalamus (MT) where the cholinergic efferent fibers of the PPN terminate was also Iesioned bilaterally by local injection of ethylcholine mustard aziridinium ion. Testing of these Iesioned rats for passive as well as active avoidance behaviors revealed that their avoidance ability was severely impaired. In both PPN- and MT-lesioned rats, the choline acetyltransferase activity decreased significantly in the MT. These findings suggest that the cholinergic PPN-MT projection plays an important role in learning and memory processes.

Keywords:
Pedunculopontine nucleus, Cholinergic pathway, Medial thalamus, Passive avoidance, Active avoidance, Ibotenic acid, Ethylcholine mustard aziridinium ion
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© 1990 S. Karger AG, Basel
1990
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