The prevalence of abnormal neurologic symptoms and signs in mildly to moderately demented patients with Alzheimer''s disease (AD) was determined by comparison with healthy control subjects, and abnormal findings in AD were examined in relation to progression of dementia, as reflected in the annual rate of change in scores on a dementia scale. Abnormalities on mental status testing were more prevalent in AD than abnormalities on symptom scales or findings on the remainder of the neurologic examination. Recent memory impairment was the most prevalent abnormality, whereas impaired object naming was most strongly associated with progression of dementia. Prominent impairment of naming and other language abilities early in the course of dementia may identify a subtype of AD characterized by more rapid progression.

Keywords:
Neurologic examination, Language impairment, Mental status testing, Progression of dementia, Alzheimer's disease
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© 1990 S. Karger AG, Basel
1990
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