Introduction: Surgery remains essential in the curative treatment of esophageal cancer (EC), but it is known for its high morbidity and impaired health-related QoL. Minimally invasive esophagectomy (MIE) was introduced to reduce surgical trauma and improve QoL. Methods: This cross-sectional study aimed to evaluate long-term HRQoL after MIE in comparison with the general population. HRQoL assessment was based on three questionnaires: the European Organisation for Research and Treatment of Cancer (EORTC) Core 30 (QLQ-C30, version 3), the EORTC QLQ Oesophago Gastric 25 (QLQ-OG25), and the Supportive Care Needs Survey-Short Form 34 (SCNS-SF34). Results were compared to a healthy reference population. Results: One hundred and forty eligible MIE patients were identified, of whom met the inclusion criteria, and 49 completed all questionnaires. Patients reported a significantly better mean score on the global health status and QoL than the healthy reference population (71.5 ± 15.1 vs. 66.1 ± 21.7; p = 0.016). However, patients scored significantly worse about functioning (physical, role, and social) (p < 0.05), fatigue (p = 0.021), eating, dysphagia, pain and discomfort, reflux, appetite loss, weight loss, coughing, and taste (p < 0.001). Discussion/Conclusion: EC survivors can reach a high global health status and QoL at least 1 year after MIE, despite long-term functional, nutritional, and gastrointestinal complaints. Patients provided written informed consent, and the study protocol was approved by the Ethics Committee of Ghent University Hospital (identifier: ID B670201940737).

1.
Booka
E
,
Takeuchi
H
,
Nishi
T
,
Matsuda
S
,
Kaburagi
T
,
Fukuda
K
,
.
The impact of postoperative complications on survivals after esophagectomy for esophageal cancer
.
Medicine
.
2015 Aug
;
94
(
33
):
e1369
. https://doi.org/10.1097/MD.0000000000001369. Erratum in: Medicine. 2015 Sep;94(39):1.
2.
Low
DE
,
Alderson
D
,
Cecconello
I
,
Chang
AC
,
Darling
GE
,
DʼJourno
XB
,
.
International consensus on standardization of data collection for complications associated with esophagectomy: esophagectomy complications consensus group (ECCG)
.
Ann Surg
.
2015 Aug
;
262
(
2
):
286
94
.
3.
Low
DE
,
Kuppusamy
MK
,
Alderson
D
,
Cecconello
I
,
Chang
AC
,
Darling
G
,
.
Benchmarking complications associated with esophagectomy
.
Ann Surg
.
2019 Feb
;
269
(
2
):
291
8
.
4.
Low
DE
,
Allum
W
,
De Manzoni
G
,
Ferri
L
,
Immanuel
A
,
Kuppusamy
M
,
.
Guidelines for perioperative care in esophagectomy: enhanced recovery after surgery (ERAS®) society recommendations
.
World J Surg
.
2019 Feb
;
43
(
2
):
299
330
.
5.
Ha
SI
,
Kim
K
,
Kim
JS
.
The influence of symptoms on quality of life among patients who have undergone oesophageal cancer surgery
.
Eur J Oncol Nurs
.
2016 Oct
;
24
:
13
9
.
6.
Jacobs
M
,
Macefield
RC
,
Elbers
RG
,
Sitnikova
K
,
Korfage
IJ
,
Smets
EMA
,
.
Meta-analysis shows clinically relevant and long-lasting deterioration in health-related quality of life after esophageal cancer surgery
.
Qual Life Res
.
2014 May
;
23
(
4
):
1155
76
.
7.
Fransen
LFC
,
Luyer
MDP
.
Effects of improving outcomes after esophagectomy on the short- and long-term: a review of literature
.
J Thorac Dis
.
2019 Apr
;
11
(
Suppl 5
):
S845
50
.
8.
Kingma
BF
,
de Maat
MFG
,
van der Horst
S
,
van der Sluis
PC
,
Ruurda
JP
,
van Hillegersberg
R
.
Robot-assisted minimally invasive esophagectomy (RAMIE) improves perioperative outcomes: a review
.
J Thorac Dis
.
2019 Apr
;
11
(
Suppl 5
):
S735
42
.
9.
van der Sluis
PC
,
Schizas
D
,
Liakakos
T
,
van Hillegersberg
R
.
Minimally invasive esophagectomy
.
Dig Surg
.
2020
;
37
(
2
):
93
100
.
10.
Hauser
C
,
Patett
C
,
von Schoenfels
W
,
Heits
N
,
Schafmayer
C
,
Malchow
B
,
.
Does neoadjuvant treatment before oncologic esophagectomy affect the postoperative quality of life? A prospective, longitudinal outcome study
.
Dis Esophagus
.
2015 Oct
;
28
(
7
):
652
9
.
11.
Osoba
D
.
Health-related quality of life and cancer clinical trials
.
Ther Adv Med Oncol
.
2011
;
3
(
2
):
57
71
.
12.
Kauppila
JH
,
Xie
S
,
Johar
A
,
Markar
SR
,
Lagergren
P
.
Meta-analysis of health-related quality of life after minimally invasive versus open oesophagectomy for oesophageal cancer
.
Br J Surg
.
2017
;
104
(
9
):
1131
40
.
13.
Luckett
T
,
King
MT
,
Butow
PN
,
Oguchi
M
,
Rankin
N
,
Price
MA
,
.
Choosing between the EORTC QLQ-C30 and FACT-G for measuring health-related quality of life in cancer clinical research: issues, evidence and recommendations
.
Ann Oncol
.
2011 Oct
;
22
(
10
):
2179
90
.
14.
Aaronson
NK
,
Ahmedzai
S
,
Bergman
B
,
Bullinger
M
,
Cull
A
,
Duez
NJ
,
.
The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology
.
J Natl Cancer Inst
.
1993 Mar 3
;
85
(
5
):
365
76
.
15.
Fayers
P
,
Aaronson
N
,
Bjordal
K
,
Groenvold
M
,
Curran
D
,
Bottomley
A
.
EORTC QLQ-C30 Scoring Manual
. 3rd ed.
Brussels, Belgium
:
EORTC publications
;
2001
.
16.
Lagergren
P
,
Fayers
P
,
Conroy
T
,
Stein
HJ
,
Sezer
O
,
Hardwick
R
,
.
Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-OG25, to assess health-related quality of life in patients with cancer of the oesophagus, the oesophago-gastric junction and the stomach
.
Eur J Cancer
.
2007 Sep
;
43
(
14
):
2066
73
.
17.
Richardson
A
,
Medina
J
,
Brown
V
,
Sitzia
J
.
Patients’ needs assessment in cancer care: a review of assessment tools
.
Support Care Cancer
.
2007
;
15
(
10
):
1125
44
.
18.
Jansen
F
,
Witte
BI
,
van Uden-Kraan
CF
,
Braspenning
AM
,
Leemans
CR
,
Verdonck-de Leeuw
IM
.
The need for supportive care among head and neck cancer patients: psychometric assessment of the Dutch version of the Supportive Care Needs Survey Short-Form (SCNS-SF34) and the newly developed head and neck cancer module (SCNS-HNC)
.
Support Care Cancer
.
2016
;
24
(
11
):
4639
49
.
19.
McElduff
P
,
Boyes
A
,
Zucca
A
,
Girgis
A
.
Supportive Care Needs Survey: A guide to administration, scoring and analysis
.
Newcastle
:
Centre for Health Research & Psycho-oncology
;
2004
.
20.
Nolte
S
,
Liegl
G
,
Petersen
MA
,
Aaronson
NK
,
Costantini
A
,
Fayers
PM
,
.
General population normative data for the EORTC QLQ-C30 health-related quality of life questionnaire based on 15,386 persons across 13 European countries, Canada and the Unites States
.
Eur J Cancer
.
2019 Jan
;
107
:
153
63
.
21.
van der Schaaf
M
,
Derogar
M
,
Lagergren
P
.
Reference values of oesophago-gastric symptoms (EORTC QLQ-OG25) in a population-based setting
.
Eur J Cancer
.
2012
;
48
(
11
):
1602
7
.
22.
Donohoe
CL
,
McGillycuddy
E
,
Reynolds
JV
.
Long-term health-related quality of life for disease-free esophageal cancer patients
.
World J Surg
.
2011
;
35
(
8
):
1853
60
.
23.
Djärv
T
,
Lagergren
J
,
Blazeby
JM
,
Lagergren
P
.
Long-term health-related quality of life following surgery for oesophageal cancer
.
Br J Surg
.
2008
;
95
(
9
):
1121
6
.
24.
Däster
S
,
Soysal
SD
,
Stoll
L
,
Peterli
R
,
von Flüe
M
,
Ackermann
C
.
Long-term quality of life after Ivor Lewis esophagectomy for esophageal cancer
.
World J Surg
.
2014
;
38
(
9
):
2345
51
.
25.
Courrech Staal
EFW
,
van Sandick
JW
,
van Tinteren
H
,
Cats
A
,
Aaronson
NK
.
Health-related quality of life in long-term esophageal cancer survivors after potentially curative treatment
.
J Thorac Cardiovasc Surg
.
2010
;
140
(
4
):
777
83
.
26.
Schwartz
CE
,
Sprangers
MAG
.
Methodological approaches for assessing response shift in longitudinal health-related quality-of-life research
.
Soc Sci Med
.
1999
;
48
(
11
):
1531
48
.
27.
Ilie
G
,
Bradfield
J
,
Moodie
L
,
Lawen
T
,
Ilie
A
,
Lawen
Z
,
.
The role of response-shift in studies assessing quality of life outcomes among cancer patients: a systematic review
.
Front Oncol
.
2019 Aug 20
;
9
:
783
.
28.
Akkerman
RDL
,
Haverkamp
L
,
van Rossum
PSN
,
van Hillegersberg
R
,
Ruurda
JP
.
Long-term quality of life after oesophagectomy with gastric conduit interposition for cancer
.
Eur J Cancer
.
2015
;
51
(
12
):
1538
45
.
29.
Finck
C
,
Barradas
S
,
Zenger
M
,
Hinz
A
.
Quality of life in breast cancer patients: associations with optimism and social support
.
Int J Clin Health Psychol
.
2018
;
18
(
1
):
27
34
.
30.
Backemar
L
,
Johar
A
,
Wikman
A
,
Zylstra
J
,
Gossage
J
,
Davies
A
,
.
The influence of comorbidity on health-related quality of life after esophageal cancer surgery
.
Ann Surg Oncol
.
2020 Aug
;
27
(
8
):
2637
45
.
31.
Jezerskyte
E
,
van Berge Henegouwen
MI
,
van Laarhoven
HWM
,
van Kleef
JJ
,
Eshuis
WJ
,
Heisterkamp
J
,
.
Postoperative complications and long-term quality of life after multimodality treatment for esophageal cancer: an analysis of the Prospective Observational Cohort Study of Esophageal-Gastric Cancer Patients (POCOP)
.
Ann Surg Oncol
.
2021 Nov
;
28
(
12
):
7259
76
.
32.
Giuliani
ME
,
Milne
RA
,
Puts
M
,
Sampson
LR
,
Kwan
JYY
,
Le
LW
,
.
The prevalence and nature of supportive care needs in lung cancer patients
.
Curr Oncol
.
2016 Aug
;
23
(
4
):
258
65
.
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