Background: Symptomatic diverticular disease is challenging for patients, clinicians and health services. The prevalence increases with age and BMI and as such, the burden of this disease is set to increase with higher rates of acute presentations already documented. The natural history of recurrent episodes, complications and symptom progression is not fully understood. Furthermore, medical and surgical management strategies are under constant appraisal, debate and evolution. Methods: A review of the contemporary literature was performed to examine the emerging trend towards conservative treatment. Results: Routine use of in-patient, intravenous antibiotics may not be required and outpatient management is possible for certain patients. Universal colonoscopy examination after uncomplicated acute diverticulitis is controversial but is mandatory after complicated episodes. Recent, high-profile, clinical trials suggest that less aggressive surgical management of both acute and chronic presentations may be feasible in some cases. Conclusions: Diverticulitis is a common yet challenging topic that demands clinicians to provide an individualised yet evidence-based approach.

1.
Jacobs DO: Clinical practice. Diverticulitis. N Engl J Med 2007; 357: 2057–2066.
2.
Kohler L, Sauerland S, Neugebauer E: Diagnosis and treatment of diverticular disease: results of a consensus development conference. The Scientific Committee of the European Association for Endoscopic Surgery. Surg Endosc 1999; 13: 430–436.
3.
Martel J, Raskin JB; NDSG: History, incidence, and epidemiology of diverticulosis. J Clin Gastroenterol 2008; 42: 1125–1127.
4.
Strate LL, Modi R, Cohen E, Spiegel BM: Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights. Am J Gastroenterol 2012; 107: 1486–1493.
5.
Kang JY, Hoare J, Tinto A, Subramanian S, Ellis C, Majeed A, et al: Diverticular disease of the colon – on the rise: a study of hospital admissions in England between 1989/1990 and 1999/2000. Aliment Pharmacol Ther 2003; 17: 1189–1195.
6.
Etzioni DA, Mack TM, Beart RW Jr, Kaiser AM: Diverticulitis in the United States: 1998–2005: changing patterns of disease and treatment. Ann Surg 2009; 249: 210–217.
7.
Comparato G, Pilotto A, Franze A, Franceschi M, Di Mario F: Diverticular disease in the elderly. Dig Dis 2007; 25: 151–159.
8.
Aune D, Sen A, Leitzmann MF, Norat T, Tonstad S, Vatten LJ: Body mass index and physical activity and the risk of diverticular disease: a systematic review and meta-analysis of prospective studies. Eur J Nutr 2017; 56: 2423–2438.
9.
Parks TG: Natural history of diverticular disease of the colon. Clin Gastroenterol 1975; 4: 53–69.
10.
Stollman N, Smalley W, Hirano I: American gastroenterological association institute guideline on the management of acute diverticulitis. Gastroenterology 2015; 149: 1944–1949.
11.
Hinchey EJ, Schaal PG, Richards GK: Treatment of perforated diverticular disease of the colon. Adv Surg 1978; 12: 85–109.
12.
Morris AM, Regenbogen SE, Hardiman KM, Hendren S: Sigmoid diverticulitis: a systematic review. JAMA 2014; 311: 287–297.
13.
Rose J, Parina RP, Faiz O, Chang DC, Talamini MA: Long-term outcomes after initial presentation of diverticulitis. Ann Surg 2015; 262: 1046–1053.
14.
Chapman JR, Dozois EJ, Wolff BG, Gullerud RE, Larson DR: Diverticulitis: a progressive disease? Do multiple recurrences predict less favorable outcomes? Ann Surg 2006; 243: 876–880; discussion 880–883.
15.
Devaraj B, Liu W, Tatum J, Cologne K, Kaiser AM: Medically treated diverticular abscess associated with high risk of recurrence and disease complications. Dis Colon Rectum 2016; 59: 208–215.
16.
Boostrom SY, Wolff BG, Cima RR, Merchea A, Dozois EJ, Larson DW: Uncomplicated diverticulitis, more complicated than we thought. J Gastrointest Surg 2012; 16: 1744–1749.
17.
Floch MH: A hypothesis: is diverticulitis a type of inflammatory bowel disease? J Clin Gastroenterol 2006; 40(suppl 3):S121–S125.
18.
Tursi A, Elisei W, Brandimarte G, Giorgetti GM, Inchingolo CD, Nenna R, et al: Musosal tumour necrosis factor α in diverticular disease of the colon is overexpressed with disease severity. Colorectal Dis 2012; 14:e258–e263.
19.
Shabanzadeh DM, Wille-Jorgensen P: Antibiotics for uncomplicated diverticulitis. Cochrane Database Syst Rev 2012; 11:CD009092.
20.
Chabok A, Påhlman L, Hjern F, Haapaniemi S, Smedh K; AVOD Study Group: Randomized clinical trial of antibiotics in acute uncomplicated diverticulitis. Br J Surg 2012; 99: 532–539.
21.
Daniels L, Ünlü Ç, de Korte N, van Dieren S, Stockmann HB, Vrouenraets BC, et al: Randomized clinical trial of observational versus antibiotic treatment for a first episode of CT-proven uncomplicated acute diverticulitis. Br J Surg 2017; 104: 52–61.
22.
Shah SD, Cifu AS: Management of acute diverticulitis. JAMA 2017; 318: 291–292.
23.
Raskin JB, Kamm MA, Jamal MM, Marquez J, Melzer E, Schoen RE, et al: Mesalamine did not prevent recurrent diverticulitis in phase 3 controlled trials. Gastroenterology 2014; 147: 793–802.
24.
Kruis W, Kardalinos V, Eisenbach T, Lukas M, Vich T, Bunganic I, et al: Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence. Aliment Pharmacol Ther 2017; 46: 282–291.
25.
Urushidani S, Kuriyama A, Matsumura M: 5-aminosalicylic acid agents for prevention of recurrent diverticulitis: a systematic review and meta-analysis. J Gastroenterol Hepatol 2018; 33: 12–19.
26.
Dughera L, Serra AM, Battaglia E, Tibaudi D, Navino M, Emanuelli G: Acute recurrent diverticulitis is prevented by oral administration of a polybacterial lysate suspension. Minerva Gastroenterol Dietol 2004; 50: 149–153.
27.
Bianchi M, Festa V, Moretti A, Ciaco A, Mangone M, Tornatore V, et al: Meta-analysis: long-term therapy with rifaximin in the management of uncomplicated diverticular disease. Aliment Pharmacol Ther 2011; 33: 902–910.
28.
Lahner E, Bellisario C, Hassan C, Zullo A, Esposito G, Annibale B: Probiotics in the treatment of diverticular disease. A systematic review. J Gastrointestin Liver Dis 2016; 25: 79–86.
29.
Balasubramanian I, Fleming C, Mohan HM, Schmidt K, Haglind E, Winter DC: Out-patient management of mild or uncomplicated diverticulitis: a systematic review. Dig Surg 2017; 34: 151–160.
30.
Joliat GR, Emery J, Demartines N, Hubner M, Yersin B, Hahnloser D: Antibiotic treatment for uncomplicated and mild complicated diverticulitis: outpatient treatment for everyone. Int J Colorectal Dis 2017; 32: 1313–1319.
31.
Lorente L, Cots F, Alonso S, Pascual M, Salvans S, Courtier R, et al: [Outpatient treatment of uncomplicated acute diverticulitis: Impact on healthcare costs]. Cir Esp 2013; 91: 504–509.
32.
Moya P, Arroyo A, Perez-Legaz J, Serrano P, Candela F, Soriano-Irigaray L, et al: Applicability, safety and efficiency of outpatient treatment in uncomplicated diverticulitis. Tech Coloproctol 2012; 16: 301–307.
33.
Boulos PB, Karamanolis DG, Salmon PR, Clark CG: Is colonoscopy necessary in diverticular disease? Lancet 1984; 1: 95–96.
34.
Levin TR, Zhao W, Conell C, Seeff LC, Manninen DL, Shapiro JA, et al: Complications of colonoscopy in an integrated health care delivery system. Ann Intern Med 2006; 145: 880–886.
35.
Walker AS, Bingham JR, Janssen KM, Johnson EK, Maykel JA, Ocampo O, et al: Colonoscopy after Hinchey I and II left-sided diverticulitis: utility or futility? Am J Surg 2016; 212: 837–843.
36.
Stefansson T, Ekbom A, Sparen P, Pahlman L: Association between sigmoid diverticulitis and left-sided colon cancer: a nested, population-based, case control study. Scand J Gastroenterol 2004; 39: 743–747.
37.
Sharma PV, Eglinton T, Hider P, Frizelle F: Systematic review and meta-analysis of the role of routine colonic evaluation after radiologically confirmed acute diverticulitis. Ann Surg 2014; 259: 263–272.
38.
Mortensen LQ, Burcharth J, Andresen K, Pommergaard HC, Rosenberg J: An 18-year Nationwide cohort study on the association between diverticulitis and colon cancer. Ann Surg 2017; 265: 954–959.
39.
Myers E, Hurley M, O'Sullivan GC, Kavanagh D, Wilson I, Winter DC: Laparoscopic peritoneal lavage for generalized peritonitis due to perforated diverticulitis. Br J Surg 2008; 95: 97–101.
40.
Toorenvliet BR, Swank H, Schoones JW, Hamming JF, Bemelman WA: Laparoscopic peritoneal lavage for perforated colonic diverticulitis: a systematic review. Colorectal Dis 2010; 12: 862–867.
41.
Schultz JK, Yaqub S, Wallon C, Blecic L, Forsmo HM, Folkesson J, et al: Laparoscopic lavage vs primary resection for acute perforated diverticulitis: the SCANDIV randomized clinical trial. JAMA 2015; 314: 1364–1375.
42.
Swank HA, Vermeulen J, Lange JF, Mulder IM, van der Hoeven JA, Stassen LP, et al: The ladies trial: laparoscopic peritoneal lavage or resection for purulent peritonitis and Hartmann's procedure or resection with primary anastomosis for purulent or faecal peritonitis in perforated diverticulitis (NTR2037). BMC Surg 2010; 10: 29.
43.
Vennix S, Musters GD, Mulder IM, Swank HA, Consten EC, Belgers EH, et al: Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial. Lancet 2015; 386: 1269–1277.
44.
Thornell A, Angenete E, Gonzales E, Heath J, Jess P, Lackberg Z, et al: Treatment of acute diverticulitis laparoscopic lavage vs. resection (DILALA): study protocol for a randomised controlled trial. Trials 2011; 12: 186.
45.
Ceresoli M, Coccolini F, Montori G, Catena F, Sartelli M, Ansaloni L: Laparoscopic lavage versus resection in perforated diverticulitis with purulent peritonitis: a meta-analysis of randomized controlled trials. World J Emerg Surg 2016; 11: 42.
46.
Angenete E, Bock D, Rosenberg J, Haglind E: Laparoscopic lavage is superior to colon resection for perforated purulent diverticulitis-a meta-analysis. Int J Colorectal Dis 2017; 32: 163–169.
47.
Cirocchi R, Di Saverio S, Weber DG, Tabola R, Abraha I, Randolph J, et al: Laparoscopic lavage versus surgical resection for acute diverticulitis with generalised peritonitis: a systematic review and meta-analysis. Tech Coloproctol 2017; 21: 93–110.
48.
Classen JN, Bonardi R, O’Mara CS, Finney DC, Sterioff S: Surgical treatment of acute diverticulitis by staged procedures. Ann Surg 1976; 184: 582–586.
49.
Cirocchi R, Afshar S, Di Saverio S, Popivanov G, De Sol A, Gubbiotti F, et al: A historical review of surgery for peritonitis secondary to acute colonic diverticulitis: from Lockhart-Mummery to evidence-based medicine. World J Emerg Surg 2017; 12: 14.
50.
Ince M, Stocchi L, Khomvilai S, Kwon DS, Hammel JP, Kiran RP: Morbidity and -mortality of the Hartmann procedure for -diverticular disease over 18 years in a single institution. Colorectal Dis 2012; 14:e492–e498.
51.
Banerjee S, Leather AJ, Rennie JA, Samano N, Gonzalez JG, Papagrigoriadis S: Feasibility and morbidity of reversal of Hartmann’s. Colorectal Dis 2005; 7: 454–459.
52.
Salem L, Flum DR: Primary anastomosis or Hartmann's procedure for patients with diverticular peritonitis? A systematic review. Dis Colon Rectum 2004; 47: 1953–1964.
53.
Wong WD, Wexner SD, Lowry A, Vernava A 3rd, Burnstein M, Denstman F, et al: Practice parameters for the treatment of sigmoid diverticulitis – supporting documentation. The Standards Task Force. The American Society of Colon and Rectal Surgeons. Dis Colon Rectum 2000; 43: 290–297.
54.
Van Arendonk KJ, Tymitz KM, Gearhart SL, Stem M, Lidor AO: Outcomes and costs of elective surgery for diverticular disease: a comparison with other diseases requiring colectomy. JAMA Surg 2013; 148: 316–321.
55.
Andeweg CS, Berg R, Staal JB, ten Broek RP, van Goor H: Patient-reported outcomes after conservative or surgical management of recurrent and chronic complaints of diverticulitis: systematic review and meta-analysis. Clin Gastroenterol Hepatol 2016; 14: 183–190.
56.
van de Wall BJM, Stam MAW, Draaisma WA, Stellato R, Bemelman WA, Boermeester MA, et al: Surgery versus conservative management for recurrent and ongoing left-sided diverticulitis (DIRECT trial): an open-label, multicentre, randomised controlled trial. Lancet Gastroenterol Hepatol 2017; 2: 13–22.
57.
Bassler D, Briel M, Montori VM, Lane M, Glasziou P, Zhou Q, et al: Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA 2010; 303: 1180–1187.
58.
Fozard JB, Armitage NC, Schofield JB, Jones OM: ACPGBI position statement on elective resection for diverticulitis. Colorectal Dis 2011; 13: 1–11.
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