Background: Choledocholithiasis is traditionally managed by endoscopic retrograde cholangiopancreatography or T-tube insertion following common bile duct exploration. This study examined the efficacy and safety of primary duct closure following laparoscopic common bile duct exploration (LCBDE) via choledochotomy. Methods: Between September 2011 and September 2013, 157 consecutive patients underwent LCBDE via choledochotomy. Results: Of 157 LCBDE procedures, 138 (87.9%) were successfully completed with primary closure of the choledochotomy. Eight patients (5.1%) underwent closure with T-tube drainage after choledochotomy and 11 patients (7.0%) were converted to open surgery. The biliary tree was free of stones at the end of surgery in 154 patients (98.1%). Postoperative bile leak occurred in 6 patients (3.8%). The median follow-up period was 18 (2-33) months, with no evidence of further bile duct stones or bile duct stricture in any patients. Univariable analysis revealed that successful duct clearance (p = 0.010) and diameter of the common bile duct (p < 0.001) were two significant risk factors for bile leak. Conclusions: Primary duct closure following LCBDE is effective and safe for the management of choledocholithiasis. The postoperative bile leak rate may be low in skilled laparoscopic surgeons with a careful selection of patients.

1.
Hungness ES, Soper NJ: Management of common bile duct stones. J Gastrointest Surg 2006;10:612-619.
2.
Ponsky JL, Heniford BT, Gersin K: Choledocholithiasis: evolving intraoperative strategies. Am Surg 2000;66:262-268.
3.
Williams EJ, Green J, Beckingham I, Parks R, Martin D, Lombard M; British Society of Gastroenterology: Guidelines on the management of common bile duct stones (CBDS). Gut 2008;57:1004-1021.
4.
Rogers SJ, Cello JP, Horn JK, Siperstein AE, Schecter WP, Campbell AR, Mackersie RC, Rodas A, Kreuwel HT, Harris HW: Prospective randomized trial of LC+LCBDE vs ERCP/S+LC for common bile duct stone disease. Arch Surg 2010;145:28-33.
5.
Bansal VK, Misra MC, Garg P, Prabhu M: A prospective randomized trial comparing two-stage versus single-stage management of patients with gallstone disease and common bile duct stones. Surg Endosc 2010;24:1986-1989.
6.
Noble H, Tranter S, Chesworth T, Norton S, Thompson M: A randomized, clinical trial to compare endoscopic sphincterotomy and subsequent laparoscopic cholecystectomy with primary laparoscopic bile duct exploration during cholecystectomy in higher risk patients with choledocholithiasis. J Laparoendosc Adv Surg Tech A 2009;19:713-720.
7.
Lu J, Cheng Y, Xiong XZ, Lin YX, Wu SJ, Cheng NS: Two-stage vs single-stage management for concomitant gallstones and common bile duct stones. World J Gastroenterol 2012;18:3156-3166.
8.
Lauter DM, Froines EJ: Laparoscopic common duct exploration in the management of choledocholithiasis. Am J Surg 2000;179:372-374.
9.
Chiarugi M, Galatioto C, Decanini L, Puglisi A, Lippolis P, Bagnato C, Panicucci S, Pelosini M, Iacconi P, Seccia M: Laparoscopic transcystic exploration for single-stage management of common duct stones and acute cholecystitis. Surg Endosc 2012;26:124-129.
10.
Hanif F, Ahmed Z, Samie MA, Nassar AH: Laparoscopic transcystic bile duct exploration: the treatment of first choice for common bile duct stones. Surg Endosc 2010;24:1552-1556.
11.
Berthou JC, Drouard F, Charbonneau P, Moussalier K: Evaluation of laparoscopic management of common bile duct stones in 220 patients. Surg Endosc 1998;12:16-22.
12.
Martin IJ, Bailey IS, Rhodes M, O'Rourke N, Nathanson L, Fielding G: Towards T-tube free laparoscopic bile duct exploration: a methodologic evolution during 300 consecutive procedures. Ann Surg 1998;228:29-34.
13.
Dindo D, Demartines N, Clavien PA: Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004;240:205-213.
14.
Phillips EH, Carroll BJ, Pearlstein AR, Daykhovsky L, Fallas MJ: Laparoscopic choledochoscopy and extraction of common bile duct stones. World J Surg 1993;17:22-28.
15.
Petelin JB: Clinical results of common bile duct exploration. Endosc Surg Allied Technol 1993;1:125-129.
16.
Gharaibeh KI, Heiss HA: Biliary leakage following T-tube removal. Int Surg 2000;85:57-63.
17.
Cai H, Sun D, Sun Y, Bai J, Zhao H, Miao Y: Primary closure following laparoscopic common bile duct exploration combined with intraoperative cholangiography and choledochoscopy. World J Surg 2012;36:164-170.
18.
El-Geidie AA: Is the use of T-tube necessary after laparoscopic choledochotomy? J Gastrointest Surg 2010;14:844-888.
19.
Leida Z, Ping B, Shuguang W, Yu H: A randomized comparison of primary closure and T-tube drainage of the common bile duct after laparoscopic choledochotomy. Surg Endosc 2008;22:1595-1600.
20.
Zhang WJ, Xu GF, Wu GZ, Li JM, Dong ZT, Mo XD: Laparoscopic exploration of common bile duct with primary closure versus T-tube drainage: a randomized clinical trial. J Surg Res 2009;157:e1-e5.
21.
Gurusamy KS, Koti R, Davidson BR: T-tube drainage versus primary closure after laparoscopic common bile duct exploration. Cochrane Database Syst Rev 2013;6:CD005641.
22.
ElGeidie AA, ElShobary MM, Naeem YM: Laparoscopic exploration versus intraoperative endoscopic sphincterotomy for common bile duct stones: a prospective randomized trial. Dig Surg 2011;28:424-431.
23.
Paganini AM, Guerrieri M, Sarnari J, De Sanctis A, D'Ambrosio G, Lezoche G, Lezoche E: Long-term results after laparoscopic transverse choledochotomy for common bile duct stones. Surg Endosc 2005;19:705-709.
24.
Khaled YS, Malde DJ, de Souza C, Kalia A, Ammori BJ: Laparoscopic bile duct exploration via choledochotomy followed by primary duct closure is feasible and safe for the treatment of choledocholithiasis. Surg Endosc 2013;27:4164-4170.
25.
Waage A, Strömberg C, Leijonmarck CE, Arvidsson D: Long-term results from laparoscopic common bile duct exploration. Surg Endosc 2003;17:1181-1185.
26.
Campbell-Lloyd AJ, Martin DJ, Martin IJ: Long-term outcomes after laparoscopic bile duct exploration: a 5-year follow up of 150 consecutive patients. ANZ J Surg 2008;78:492-494.
27.
Decker G, Borie F, Millat B, Berthou JC, Deleuze A, Drouard F, Guillon F, Rodier JG, Fingerhut A: One hundred laparoscopic choledochotomies with primary closure of the common bile duct. Surg Endosc 2003;17:12-18.
28.
Alhamdani A, Mahmud S, Jameel M, Baker A: Primary closure of choledochotomy after emergency laparoscopic common bile duct exploration. Surg Endosc 2008;22:2190-2195.
29.
Gholipour C, Shalchi RA, Abassi M: Efficacy and safety of early laparoscopic common bile duct exploration as primary procedure in acute cholangitis caused by common bile duct stones. J Laparoendosc Adv Surg Tech A 2007;17:634-638.
30.
Jameel M, Darmas B, Baker AL: Trend towards primary closure following laparoscopic exploration of the common bile duct. Ann R Coll Surg Engl 2008;90:29-35.
31.
Koc B, Karahan S, Adas G, Tutal F, Guven H, Ozsoy A: Comparison of laparoscopic common bile duct exploration and endoscopic retrograde cholangiopancreatography plus laparoscopic cholecystectomy for choledocholithiasis: a prospective randomized study. Am J Surg 2013;206:457-463.
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