Over the last 20 years, a new concept of perioperative patient care based on a construct of evidence-based interventions referred to as ‘enhanced recovery after surgery' (ERAS) has been developed. The main pillars of ERAS programs include optimal postoperative pain management and early enteral feeding and mobilization after surgery. Several studies, mostly based on experiences with patients undergoing colonic resection, suggest that ERAS implementation is feasible and safe. However, there are very few well-designed studies that have evaluated the usefulness of ERAS programs after major upper abdominal surgery. The present review focuses on the discussion of the most relevant and recently published data on the application of ERAS programs in pancreatic, hepatic, esophageal and gastric surgery. A total of 23 articles have been reviewed by the authors. The high frequency and the potentially hazardous nature of some postoperative complications associated with major upper abdominal surgery and the lack of well-designed randomized controlled trials are limiting factors for the application of ERAS. However, the present results indicate that the implementation of ERAS programs in pancreatic, hepatic, esophageal and gastric surgery patients contributes to a reduction in complications, length of hospital stay and costs without an increase in mortality or readmission rates.

1.
Kehlet H, Wilmore DW: Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg 2008;248:189-198.
2.
Basse L, Raskov HH, Hjort Jakobsen D, Sonne E, Billesbolle P, Hendel HW, et al: Accelerated postoperative recovery programme after colonic resection improves physical performance, pulmonary function and body composition. Br J Surg 2002;89:446-453.
3.
Kehlet H: Fast-track surgery - an update on physiological care principles to enhance recovery. Langenbecks Arch Surg 2011;396:585-590.
4.
Kehlet H: Multimodal approach to postoperative recovery. Curr Opin Crit Care 2009;15:355-358.
5.
Olsen MF, Wennberg E: Fast-track concepts in major open upper abdominal and thoracoabdominal surgery: a review. World J Surg 2011;35:2586-2593.
6.
Varadhan KK, Lobo DN, Ljungqvist O: Enhanced recovery after surgery: the future of improving surgical care. Crit Care Clin 2010;26:527-547.
7.
Melnyk M, Casey RG, Black P, Koupparis AJ: Enhanced recovery after surgery (ERAS) protocols: time to change practice? Can Urol Assoc J 2011;5:342-348.
8.
Kehlet H: Fast-track colorectal surgery. Lancet 2008;371:791-793.
9.
Lemmens L, van Zelm R, Borel Rinkes I, van Hillegersberg R, Kerkkamp H: Clinical and organizational content of clinical pathways for digestive surgery: a systematic review. Dig Surg 2009;26:91-99.
10.
Gravante G, Elmussareh M: Enhanced recovery for non-colorectal surgery. World J Gastroenterol 2012;18:205-211.
11.
Adamina M, Kehlet H, Tomlinson GA, Senagore AJ, Delaney CP: Enhanced recovery pathways optimize health outcomes and resource utilization: a meta-analysis of randomized controlled trials in colorectal surgery. Surgery 2011;149:830-840.
12.
Spanjersberg WR, Reurings J, Keus F, van Laarhoven CJ: Fast track surgery versus conventional recovery strategies for colorectal surgery. Cochrane Database Syst Rev 2011;2:CD007635.
13.
Khoo CK, Vickery CJ, Forsyth N, Vinall NS, Eyre-Brook IA: A prospective randomized controlled trial of multimodal perioperative management protocol in patients undergoing elective colorectal resection for cancer. Ann Surg 2007;245:867-872.
14.
Gouvas N, Tan E, Windsor A, Xynos E, Tekkis PP: Fast-track vs standard care in colorectal surgery: a meta-analysis update. Int J Colorectal Dis 2009;24:1119-1131.
15.
Gatt M, Anderson AD, Reddy BS, Hayward-Sampson P, Tring IC, MacFie J: Randomized clinical trial of multimodal optimization of surgical care in patients undergoing major colonic resection. Br J Surg 2005;92:1354-1362.
16.
Porter GA, Pisters PW, Mansyur C, Bisanz A, Reyna K, Stanford P, et al: Cost and utilization impact of a clinical pathway for patients undergoing pancreaticoduodenectomy. Ann Surg Oncol 2000;7:484-489.
17.
Wichmann MW, Roth M, Jauch KW, Bruns CJ: A prospective clinical feasibility study for multimodal ‘fast track' rehabilitation in elective pancreatic cancer surgery. Rozhl Chir 2006;85:169-175.
18.
Berberat PO, Ingold H, Gulbinas A, Kleeff J, Muller MW, Gutt C, et al: Fast track - different implications in pancreatic surgery. J Gastrointest Surg 2007;11:880-887.
19.
Kennedy EP, Rosato EL, Sauter PK, Rosenberg LM, Doria C, Marino IR, et al: Initiation of a critical pathway for pancreaticoduodenectomy at an academic institution - the first step in multidisciplinary team building. J Am Coll Surg 2007;204:917-923.
20.
Balzano G, Zerbi A, Braga M, Rocchetti S, Beneduce AA, Di Carlo V: Fast-track recovery programme after pancreatico-duodenectomy reduces delayed gastric emptying. Br J Surg 2008;95:1387-1393.
21.
Kennedy EP, Grenda TR, Sauter PK, Rosato EL, Chojnacki KA, Rosato FE Jr, et al: Implementation of a critical pathway for distal pancreatectomy at an academic institution. J Gastrointest Surg 2009;13:938-944.
22.
Montiel Casado MC, Pardo Sanchez F, Rotellar Sastre F, Marti Cruchaga P, Alvarez Cienfuegos FJ: Experience of a cephalic pancreatoduodenectomy fast-track program (in Spanish). Cir Esp 2010;87:378-384.
23.
di Sebastiano P, Festa L, De Bonis A, Ciuffreda A, Valvano MR, Andriulli A, et al: A modified fast-track program for pancreatic surgery: a prospective single-center experience. Langenbecks Arch Surg 2011;396:345-351.
24.
Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, et al: Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg 2002;236:397-406.
25.
Cescon M, Vetrone G, Grazi GL, Ramacciato G, Ercolani G, Ravaioli M, et al: Trends in perioperative outcome after hepatic resection: analysis of 1500 consecutive unselected cases over 20 years. Ann Surg 2009;249:995-1002.
26.
MacKay G, O'Dwyer PJ: Early discharge following liver resection for colorectal metastases. Scott Med J 2008;53:22-24.
27.
van Dam RM, Hendry PO, Coolsen MM, Bemelmans MH, Lassen K, Revhaug A, et al: Initial experience with a multimodal enhanced recovery programme in patients undergoing liver resection. Br J Surg 2008;95:969-975.
28.
Stoot JH, van Dam RM, Busch OR, van Hillegersberg R, De Boer M, Olde Damink SW, et al: The effect of a multimodal fast-track programme on outcomes in laparoscopic liver surgery: a multicentre pilot study. HPB (Oxford) 2009;11:140-144.
29.
Lin DX, Li X, Ye QW, Lin F, Li LL, Zhang QY: Implementation of a fast-track clinical pathway decreases postoperative length of stay and hospital charges for liver resection. Cell Biochem Biophys 2011;61:413-419.
30.
Zehr KJ, Dawson PB, Yang SC, Heitmiller RF: Standardized clinical care pathways for major thoracic cases reduce hospital costs. Ann Thorac Surg 1998;66:914-919.
31.
Brodner G, Pogatzki E, Van Aken H, Buerkle H, Goeters C, Schulzki C, et al: A multimodal approach to control postoperative pathophysiology and rehabilitation in patients undergoing abdominothoracic esophagectomy. Anesth Analg 1998;86:228-234.
32.
Neal JM, Wilcox RT, Allen HW, Low DE: Near-total esophagectomy: the influence of standardized multimodal management and intraoperative fluid restriction. Reg Anesth Pain Med 2003;28:328-334.
33.
Low DE, Kunz S, Schembre D, Otero H, Malpass T, Hsi A, et al: Esophagectomy - it's not just about mortality anymore: standardized perioperative clinical pathways improve outcomes in patients with esophageal cancer. J Gastrointest Surg 2007;11:1395-1402.
34.
Cerfolio RJ, Bryant AS, Bass CS, Alexander JR, Bartolucci AA: Fast tracking after Ivor Lewis esophagogastrectomy. Chest 2004;126:1187-1194.
35.
Jiang K, Cheng L, Wang JJ, Li JS, Nie J: Fast track clinical pathway implications in esophagogastrectomy. World J Gastroenterol 2009;15:496-501.
36.
Munitiz V, Martinez-de-Haro LF, Ortiz A, Ruiz-de-Angulo D, Pastor P, Parrilla P: Effectiveness of a written clinical pathway for enhanced recovery after transthoracic (Ivor Lewis) oesophagectomy. Br J Surg 2010;97:714-718.
37.
Preston SR, Markar SR, Baker CR, Soon Y, Singh S, Low DE: Impact of a multidisciplinary standardized clinical pathway on perioperative outcomes in patients with oesophageal cancer. Br J Surg 2013;100:105-112.
38.
Low DE: Evolution in perioperative management of patients undergoing oesophagectomy. Br J Surg 2007;94:655-656.
39.
Grantcharov TP, Kehlet H: Laparoscopic gastric surgery in an enhanced recovery programme. Br J Surg 2010;97:1547-1551.
40.
Wang D, Kong Y, Zhong B, Zhou X, Zhou Y: Fast-track surgery improves postoperative recovery in patients with gastric cancer: a randomized comparison with conventional postoperative care. J Gastrointest Surg 2010;14:620-627.
41.
Liu XX, Jiang ZW, Wang ZM, Li JS: Multimodal optimization of surgical care shows beneficial outcome in gastrectomy surgery. JPEN J Parenter Enteral Nutr 2010;34:313-321.
42.
Yamada T, Hayashi T, Cho H, Yoshikawa T, Taniguchi H, Fukushima R, et al: Usefulness of enhanced recovery after surgery protocol as compared with conventional perioperative care in gastric surgery. Gastric Cancer 2012;15:34-41.
43.
Chen Hu J, Xin Jiang L, Cai L, Tao Zheng H, Yuan Hu S, Bing Chen H, et al: Preliminary experience of fast-track surgery combined with laparoscopy-assisted radical distal gastrectomy for gastric cancer. J Gastrointest Surg 2012;16:1830-1839.
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