Aim: This study aimed at determining the reoperation rates of patients with anastomoses for Crohn’s disease. The outcome of patients undergoing stapled anastomoses was compared with that of patients having hand-sewn anastomoses. Methods: Sixty-three patients undergoing intestinal resection for Crohn’s disease at our institution from 1987 to 1996 were studied in a prospective, randomized trial. The group undergoing stapling comprised 30 patients and 37 anastomoses. The group with a hand-sewn anastomosis comprised 33 patients and 45 anastomoses. The median follow-up period was 87 (range 36–140) months. Results: There were no significant differences in operative indications or patients’ age and sex between the groups. There was a significant difference in cumulative recurrences between the groups (Cox-Mantel test: p = 0.022). Conclusion: A stapled anastomosis after resection for Crohn’s disease may delay reoperation in patients with symptomatic recurrence.

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