In this study, biological and morphological changes in three synthetic absorbable suture materials, namely poliglecaprone 25 (Monocryl), polyglactin 910 (coated Vicryl), and polydiaxanone (PDSII), in acidic and alkaline buffer solutions, bile, and pancreatic juice, and tissue reactions to these materials were compared. The natural absorbable suture, chromic catgut, was used as a control. When the sutures were immersed in acidic and alkaline pH buffer solutions, bile, and pancreatic juice, the decreases in the tensile strength of Monocryl in pancreatic juice and PDS II in the acidic solution were marked. Bile had little specific effect on Monocryl or coated Vicryl. When the sutures were used in surgery of the biliary tract and the pancreas, tissue reactions, evaluated on the basis of the degrees of granulation and fibrosis, were milder in Monocryl than coated Vicryl. These results suggest that Monocryl sutures can be a possible choice in surgery of the biliary tract. In the selection of sutures, it is important to remember that preserving tensile strength and the tissue reactions may differ greatly depending on the tissue in which they are used.

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