Treatment of chronic pancreatitis has traditionally been relegated to medical or surgical therapy. Aim: This article attempts to place pancreatic endotherapy into the perspective of current treatment modalities. Materials and Methods: Personal experience and literature review. Results: Endotherapy attempts to mimic portions of our current surgical and interventional radiologic maneuvers: treatment of ductal disruption or obstruction. As such, ERCP has been used to approach stenosis of the major or minor papilla, ductal calculi or strictures, and ductal leak with its attendant consequences of pancreatic ascites, pleural effusion, pseudocyst or pancreaticocutaneous fistulae. Conclusions: Despite a paucity of controlled clinical trials, the authors feel that endotherapy has an evolving role to play in a variety of problems associated with chronic pancreatitis.

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