... in lesional skin remains unknown. In the present study, a sensitive and quantitative technique for detection of the KIT D816V mutation was therefore used to assess the levels of mutation in skin biopsies in a series of adults with SM. KIT D816V mutation Urticaria pigmentosa Systemic mastocytosis ...

...Hassan Abd El-Aal; Abd El-Wahed Boseila; Wagih K. Bayoomy; Sayed Zaki Salem Five cases of urticaria pigmentosa in patients of different ages and of both sexes were studied for mast cell changes and alkaline phosphatase activity. It has been found that mast cells were very rich in the enzyme...

...Rune Lindskov; Gunhild Lange Wantzin; Lone Knudsen; Ib Søndergaard 4 patients with urticaria pigmentosa were treated with oral disodium cromoglycate (DSCG) for 2 months. During the treatment urine excretion of the main histamine metabolite, 1,4-methylimidazoleacetic acid (MIAA), was determined...

...Beate M. Czarnetzki 10 adult patients with symptomatic urticaria pigmentosa were treated with ketotifen versus placebo in a double-blind cross-over study. A highly significant reduction of the daily symptom scores for pruritus and whealing was found with 2 mg ketotifen daily per os, and, compared...

...Masashi Akiyama; Yonosuke Watanabe; Takeji Nishikawa The morphology of mast cells in the skin lesion from a case of urticaria pigmentosa was observed using light and electron microscopy. Furthermore, the IgE deposition on mast cells in the lesion was studied with immunoelectron microscopy...

... or histamine. From these data we propose the following possible mechanisms for hyperpigmentations noted at postinflammatory sites and suntanned areas as well as at skin lesions of urticaria pigmentosa. Arachidonic acid metabolites and histamine, which are found in increased amounts in inflammatory skin...

... of steroids is the depletion of skin mast cells. This led to the treatment of patients with urticaria pigmentosa with topical high potency corticosteroids for 6 weeks. At the end of treatment there was a marked reduction in tissue histamine and an absence of mast cells as well as a disappearance of pruritus...

...M. Akiyama; Y. Sasaki; S. Takahashi; K. Hayakawa; H. Suzuki; T. Nishikawa We report a case of urticaria pigmentosa, acromegaly and acanthosis nigricans in a 25-year-old male. The patient exhibited multiple pigmented papules on the trunk and the extremities. Histological examinations of the papules...

...O. Godt; E. Proksch; V. Streit; E. Christophers Background: Previous studies have shown that oral PUVA is effective in urticaria pigmentosa. Long-term results, however, are unknown. Objective: We studied the long-term effectiveness of oral PUVA treatment in urticaria pigmentosa as well...

...Matthias Möhrenschlager; Reinhard Engst; Stefan Müller-Weihrich; Walter Spiessl; Klaus Rüdisser; Lorenz B. Weigl; Berthold Jessberger; Markus Braun-Falco; Dietrich Abeck; Johannes Ring Background: Urticaria pigmentosa (UP) is characterized by dense aggregates of mast cells in the dermis...