... onychomycosis. Methods: In this European, multicenter, randomized, parallel-group, open-label, active-controlled study, male or female adult patients with distal-lateral or lateral subungual dermatophyte onychomycosis on at least 12.5% of the great toenail were randomized either to a 40% urea ointment...

... Allantoin Urea Dermatologica 147: 338-341 (1973) Allantoin in Treatment of Psoriasis E. Young Department of Dermatology (Head: Prof. L. H. Jansen), University Hospital, Utrecht Abstract. By means of the method of paired comparisons, the value of the treatment of psoriasis by allantoin was investigated...

...W. Wohlrab; W. Böhm The epidermis thins in response to short-term contact with urea, and the results of extensive enzymological and autoradiographical studies suggest that urea acts on processes involved in epidermal proliferation. After long-term exposure of skin to urea, lasting more than 2, 4...

...W. Wohlrab The thinning of epidermis after urea treatment is explicable theoretically in several ways. We take the estimation of epidermal DNA synthesis measured autoradiographically by 3 H-thymidine incorporation for a valid contribution to solve this question. As a result, the number of labeled...

...Lars Hellgren; Kåre Larsson The effect of urea on the horny layer of human epidermis has been studied with special regard to its osmotic and keratolytic effects. It has been shown that the water-binding capacity mainly must be of osmotic nature; the same effects could be achieved with about half...

...J.C. Guillaume; J. De Rigal; J.L. Levèque; P. Galle; R. Touraine; L. Dubertret Modifications of transepidermal water loss due to repeated topical applications of water/oil emulsion, salicylic acid and urea, with and without occlusion, were studied on the forearms of healthy volunteers. Percutaneous...

...W. Wohlrab The influence of urea on the percutaneous permeation under different conditions of application and on the epidermal effectiveness of 5-fluorouracil (FU) as an example for water-soluble agents is reported. The proceedings of permeation of FU are accelerated by admixture...

...W. Wohlrab Long-term application up to 8 weeks of a 10% urea solution provokes an epidermal thinning expressed in a decreased number of DNA-synthetizing cells. This epidermal reaction cannot be established after topical use of HTH® emulsion. Even by daily application during 8 weeks no change...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Nail diseases Tinea unguium Urea Imidazoles Dermatologica 165: 54-61 (1982...

... is the removal of as much fungus-infected nail material as possible, or else bioavailability at the site of infection cannot, or only hardly, be guaranteed. In our investigations into the treatment of onychomycosis we studied the use of bifonazole1 (1%)-urea ointment and the therapeutic possibilities...

...W. Wohlrab Prerequisite to any efficiency of urea in the skin is its penetration into the different skin layers. In addition to the differences in the reactivity of the skin, the ointment base is the most important factor for the intensity and the course of urea penetration. For the penetration...