... and the efficacy of different therapeutic approaches to prevent and treat dermatoporosis have not been investigated so far. Objective: We examined the possible effect of topical retinaldehyde (RAL) and defined-size hyaluronate fragments (HAFi) on the expression of hyalurosome genes potentially involved...

...O. Sorg; B. Kasraee; D. Salomon; J.-H. Saurat Background: Retinoids have been reported to exert depigmenting activity. Unlike most depigmenting agents that target tyrosinase, they are not phenolic agents and may act via different mechanisms. Objectives: We analysed the properties of retinaldehyde...

...O. Sorg; B. Kasraee; D. Salomon; J.H. Saurat Background: Cutaneous pigmented lesions urge the need to find safe and effective treatments to lighten the skin. Objective: The aim of this study was to combine a retinoid (retinaldehyde), a new phenolic agent (4-(1-phenylethyl)-resorcinol...

...% retinaldehyde/6% glycolic acid (RALGA) cream at preventing and treating acne scarring in patients previously treated for moderate acne. Methods: A double-blind vehicle-controlled study was conducted in 145 patients randomized to apply RALGAor vehicle cream every evening for 3 months. Global scarring score...

... as an irritant and can produce considerable erythema and exfoliation of skin. Second, RA has a relatively weak depigmenting ability compared to other known depigmenting chemicals. Objective: In this study, we show that RALGA, a combination of the less irritant retinoid retinaldehyde (RAL; 0.1%) and glycolic acid...

... treatments (secondary inflammation) is a hindrance to therapy. Retinaldehyde (RAL), a precursor of retinoic acid, has shown depigmenting activity. Glycolic acid (GA) decreases the excess of pigment by a wounding and re-epithelization process. Thus, a synergistic effect was expected from the combination...

...Sylvie Boisnic; Marie-Christine Branchet-Gumila; Thérèse Nocera; François Verrière Background: Retinaldehyde and glycolic acid RALGA (Diacnéal ® ) are both effective in the topical treatment of acne. A decrease in the postinflammatory pigmentation has been observed after application of Diacnéal...

...F. Poli; V. Ribet; C. Lauze; H. Adhoute; P. Morinet Background: Retinaldehyde and glycolic acid are both efficient in acne. Objective: To evaluate the efficacy and tolerability of a 0.1% retinaldehyde/6% glycolic acid combination (Diacnéal ® ) for mild to moderate acne vulgaris. Methods: Overall...

...P. Bordat; S. Chesnoy Background: The use of retinaldehyde or glycolic acid was found to be effective in topical acne treatments. Objective: The aim of this study was thus to take advantage of the possible synergistic effect between retinaldehyde and glycolic acid and to combine the latter...

...B. Dréno; T. Nocera; F. Verrière; M.P. Vienne; C. Ségard; S. Vitse; C. Carré Background: Retinaldehyde (RAL), a key metabolite between vitamin A and retinoic acid, acts by modulating differentiation and proliferation of keratinocytes, which is of interest in acne lesions, mainly retentional lesions...

...M. Pechère; L. Germanier; G. Siegenthaler; J.-C. Pechère; J.-H. Saurat Background: Retinoids such as retinoic acid (RA), retinol (ROL) and retinaldehyde (RAL) are currently used in many formulations and indications ranging form acne to skin aging. Most if not all their pharmacological activities...

...P. Creidi; Ph. Humbert Background: Retinaldehyde, the natural precursor of retinoic acid, should exert similar effects on photoaged skin. Objective: To establish the efficacy and safety of topical retinaldehyde on photoaged skin. Methods: Open and controlled clinical studies using image analysis...

... of a topical formulation with the retinoic acid precursor retinaldehyde, in patients with vascular signs of facial rosacea. Methods: Female patients were treated with a 0.05% retinaldehyde cream that was applied once daily for 6 months. Clinical assessments of persistent erythema and telangiectasia were...

...), retinaldehyde (RAL) and RA. Methods: ROL, RAL and RA were studied using repeated insult patch tests for 14 days (n = 6). Similarly, RAL and RA were assessed in long-term clinical use for 44 weeks (n = 355). Clinical scoring on irritation, measurement of transepidermal water loss (barrier function) and laser...

...E.M. Sachsenberg-Studer Background: Retinaldehyde (RAL) has been used as a topical agent in many countries since 1994. Aim: To review current data on the tolerance of retinaldehyde and to report the results of a long-term pilot study. Methods: Data from published and on-file studies have been...

... is the most omnipotent compound, natural retinoids like all- trans- , 9-cis- and didehydroretinoic acid (RA) are clearly more potent outside the retina and trigger gene expression via binding to nucelar retinoid receptors. Retinaldehyde takes an intermediate position in this respect, with ability to convert...

... be related to an effect on rosacea. Aim: To investigate the effect of retinaldehyde on VEGF production by human keratinocytes. Methods: The effects of different concentrations of retinoids (all- trans -retinal and all- trans -retinoic acid) on VEGF production by cultured human skin keratinocytes in both cell...

...% retinaldehyde with an ex vivo technique using human skin in order to approximate in vivo metabolic conditions. Methods: Human skin explants were maintained alive in organ culture for 18 days and subjected to UVA exposure, thus simulating skin photoaging. Retinaldehyde cream was then applied to the surface...

...L. Fort-Lacoste; Y. Verscheure; J. Tisne-Versailles; R. Navarro Background: Retinaldehyde is a key molecule in the metabolism of vitamin A by keratinocytes. In order to evaluate its range of topical activity in acne, its comedolytic effect was compared to that of retinoic acid in the same vehicle...

... of topical retinaldehyde and its conversion into either retinoid stores or biologically active metabolites. Methods: (i) 3 H-retinaldehyde was used as a precursor of either 3 H-retinol or 3 H-retinoic acid in human skin extracts and human cultured keratinocytes; (ii) the concentration of various retinoids...