...Catalina Hartmann Skovsgård; Trine Bay Laurberg; Anders Dige; Lars Iversen; Kasper Fjellhaugen Hjuler Background: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis that occurs in a large proportion of patients with psoriasis causing pain and impaired quality of life. Early recognition...

...Zheng Su; Yue-Ping Zeng Background: Dupilumab is the first approved IL-4Rα inhibitor for the treatment of atopic dermatitis at present with good efficacy and safety. However, there have been several reports of psoriasis and psoriasiform manifestations occurring after dupilumab therapy in recent...

...Chin-Hsiao Tseng Background: Metformin’s effects on non-cancer skin diseases are rarely investigated. Objective: The aim of the study was to investigate immune-mediated (urticaria, allergic contact dermatitis, and psoriasis) and androgen-mediated (acanthosis nigricans, hidradenitis suppurativa...

...Teng-Li Lin; Ching-Min Kuo; Yi-Ling Chang; Hsiu J. Ho; Yi-Ju Chen; Chun-Ying Wu Background: Acitretin has been linked to the development of psychiatric disturbance. Objectives: The aim of this study was to assess the psychiatric hazards in patients with psoriasis prescribed acitretin compared...

.... Objectives: The objective of this study was to assess patients’ understanding of PsD, associated comorbidities, disease burden, and relationships with healthcare professionals (HCPs). Methods: Psoriasis and Beyond was a cross-sectional, quantitative online survey conducted in patients with a self-reported...

...Zhijia Fan; Qiong Huang; Zhenghua Zhang; Ling Han; Xu Fang; Ke Yang; Guiqin Huang; Zhizhong Zheng; Nikhil Yawalkar; Yong Lin; Zhicheng Wang; Kexiang Yan Background: The study aimed to investigate the relationship of MAPK4 genetic variants with the efficacy of methotrexate (MTX) in psoriasis...

...), and strive to maximize the value created. Value in this context is defined as the health outcomes achieved per costs made. We have designed a lean IPU called PsoPlus in which psoriasis patients are managed by a multidisciplinary team which has all the expertise and skill to manage psoriasis and its...

...Siew Eng Choon; Mark G Lebwohl; Hamida Turki; Min Zheng; A. David Burden; Ling Li; Manuel Quaresma; Christian Thoma; Hervé Bachelez Background: Generalized pustular psoriasis (GPP) is a rare, neutrophilic skin disease that can become life-threatening if flares are untreated. There are limited data...

...: The objective of this study was to assess the long-term survival rates of adalimumab and infliximab in real-life practice. Methods: This study is based on data from the Turkish Psoriasis Registry and the digital records of the Medical School of Bezmialem Vakif University. Baseline data including demographic...

...) in patients with moderate-to-severe psoriasis. However, the clinical meaningfulness and predictive factors of CSC in daily practice have not yet been fully investigated. Objective: The study was conducted to, first, assess the impact of CSC on quality of life (QoL) improvements compared with treatment...

...Jenny M Norlin; Sofia Löfvendahl; Marcus Schmitt-Egenolf Background: Interleukin (IL) inhibitors have made completely cleared skin achievable for many patients with moderate to severe psoriasis in clinical trial settings. Few observational studies assess treatment response in accordance...

...Marta Laskowski; Linus Schiöler; Ann-Marie Wennberg; Kjell Torén; Helena Gustafsson Background: The self-assessment psoriasis area severity index (SAPASI) is a patient-administered psoriasis assessment tool for which we present a validated translation from English to Swedish. Methods: Validity...

...Xiaoying Sun; Xiaoce Cai; Liu Liu; Hongjin Li; Yaqiong Zhou; Ying Luo; Yonghua Su; Bin Li; Xin Li Background: Psoriasis is a chronic recurrent inflammatory skin disease with a high risk of diabetes based on disease severity. Objectives: The aim of the study was to evaluate the efficacy of different...

...Zhaoyang Wang; Yunliu Chen; Xin Xiang; Yang Gu; Mutong Zhao; Yuanxiang Liu; Yachen Wang; Zigang Xu Background: The scientific evidence of methotrexate (MTX) in children with severe plaque psoriasis is scarce. Objectives: To retrospectively evaluate the efficacy and safety of oral MTX in children...

...Piyu Parth Naik Background: Psoriasis is an immune-mediated protracted ailment that perturbs about 100 million people globally. Anti-interleukin (IL)-23 agents have a distinctive status of safety and clinical efficacy. Anti-IL-23 operatives have demonstrated therapeutic prominences in cases...

...Juliëtte N. Pouw; Marleen E. Jacobs; Deepak M.W. Balak; Jacob M. van Laar; Paco M.J. Welsing; Emmerik F.A. Leijten Background: Early identification of patients at risk of psoriatic arthritis (PsA) is essential to facilitate early diagnosis and improve clinical outcomes. Severe cutaneous psoriasis...

... keratinocyte terminal differentiation in normal human epidermis, exerting a homeostatic role. Psoriasis Atopic dermatitis Hidradenitis suppurativa Keratinocyte differentiation 3D organotypic cultures Across the board of different cytokines able both to act on other immune cells...

... educational program on HRQoL and disease severity in patients with psoriasis or atopic dermatitis (AD). Methods: Sixty-four patients with diagnosed psoriasis or AD were recruited from University Hospital Zurich and randomized (1:1) to the intervention or control group. To assess HRQoL, the following self...

...Augusta Ortolan; Mariagrazia Lorenzin; Giovanni Leo; Francesca Pampaloni; Francesco Messina; Andrea Doria; Stefano Piaserico; Roberta Ramonda Background: Secukinumab effectiveness has been demonstrated in both psoriasis (PsO) and psoriatic arthritis (PsA). However, it is unknown whether patients...

...Rivka Friedland; Khalaf Kridin; Arnon Dov Cohen; Daniel Landau; Dan Ben-Amitai Background: Psoriasis is a systemic disease with associated comorbidities. An association between renal diseases and psoriasis has previously been reported in adult patients, but little is known about renal diseases...