...Mohamed Badawy Abdel-Naser; Aikaterini I. Liakou; Rana Elewa; Sabine Hippe; Jürgen Knolle; Christos C. Zouboulis Background: Psoriatic lesions may resolve with hypo- or hyperpigmentation. The involvement of melanocytes in this dichotomous clinical outcome is not fully investigated. Objectives...

...Ene Reimann; Külli Kingo; Maire Karelson; Paula Reemann; Ulvi Loite; Maris Keermann; Kristi Abram; Eero Vasar; Helgi Silm; Sulev Kõks Background: Dopamine has been proven to be toxic for melanocytes. In vitiligo patients the level of dopamine is increased and the functioning of several enzymes...

...Luyan Tang; Jian Li; Xiao Lin; Wenyu Wu; Kefei Kang; Wenwen Fu Background: UVB light can generate potentially harmful hydrogen peroxide (H 2 O 2 ) in vivo, but it can also promote the beneficial proliferation and migration of melanocytes. The successful use of UVB monotherapy for treatment...

...C.J. Guerrier; M.A. Lutzner; V. Devico; M. Prunieras The skin of 18 cases of xeroderma pigmentosum was examined electronmicroscopically. In all cases, the melanocytes were abnormal. They showed extensive melanosome polymorphism, the formation of large autophagic vacuoles; in eight cases, giant...

... deposition of melanin into the dermis by epidermal melanocytes and an abnormal population of melanocytes high in the epidermis were noted. Also deposition of melanin in Schwann cells was seen. With the passage of time there was first dysfunction and finally atrophy of melanocytes and dispersal of the dermal...

..., histochemical and electron microscopical studies performed on 5 of the patients revealed a greatly increased number of melanocytes in the macules, hyperactivity of the melanocytes and increased transfer of pigment to dermis and keratinocytes. Moreover, binucleated cells were found as well as multifarious signs...

...L. Kanerva; J. Lauharanta; K.-M. Niemi; T. Juvakoski; A. Lassus Persistent ashen-gray maculae 5–7 mm in diameter and freckles developed after prolonged PUVA therapy of psoriasis. Histopathology of maculae showed extensive collections of melanophages in the upper dermis. The melanocytes were...

.... Moreover, there were much fewer melanocytes and melanosomes in the epidermis of both lesions. The corneal layer of the brown papules was far thicker than that of the leukoderma. Therefore, the thick corneal layer of the brown papules may prolong the retention of a few melanosomes or a little melanin...

...Wolfgang Vanscheidt; Thomas Hunziker Background: Treatment of depigmented skin is an unmet medical need. Objective: Melanocytes or stem cells thereof residing in the outer root sheath (ORS) of hair follicles might be used to repigment skin. Methods: After de-epidermisation, autologous ORS cell...

...Cristina Carrera; Susana Puig; Alex Llambrich; Josep Palou; Mario Lecha; Daniela Massi; Josep Malvehy Background: Ultraviolet radiation (UVR) plays an important role in the development of melanocytic lesions. Sunscreens have shown an impact in the prevention of UVR damage; however, their role...

... transplantation in treating stabilized vitiligo using objective and subjective evaluation methods. Methods: Noncultured autologous melanocytes and keratinocytes were grafted in a hyaluronic-acid-enriched suspension on superficially laser-abraded vitiligo lesions in 40 patients with refractory stable vitiligo (30...

... (6.4%), has a higher skin-depigmenting potential than RA 0.05% in the tail skin of C57BL/6 mice. This effect was observed in reducing the number of functioning melanocytes and/or in inhibiting their ability to synthesise melanin. In addition, the visually recognisable depigmenting effect of RALGA...

...M. Bacharach-Buhles; M. Lubowietzki; P. Altmeyer Background: Intense UVA irradiation induces an increase in number, size and activity of intraepidermal melanocytes. The number of melanocytes and the activity of melanogenesis return to normal after cessation of irradiation. Objective: In this study...