...Beate M. Czarnetzki 10 adult patients with symptomatic urticaria pigmentosa were treated with ketotifen versus placebo in a double-blind cross-over study. A highly significant reduction of the daily symptom scores for pruritus and whealing was found with 2 mg ketotifen daily per os, and, compared...

...) and ketotifen (2 mg daily) led to complete resolution of all facial lesions. The pathogenesis of persistent edema remains mysterious but may be related to chronic inflammation resulting in obstruction of lymph vessels or fibrosis induced by mast cells. 21 09 1992 28 10 1992 7 10 2009 ©...

... lesions. Cutaneous biopsy demonstrated diffuse cutaneous mastocytosis. The bone marrow aspirate revealed mast cell infiltration. Ketotifen treatment was very effective. Case Report Dermatology 1993:187:127-129 N. Olgun, H. Ören B. Ören, G. Irken M. Point, N. Qevik Department of Pediatrics, Faculty...