... clinically, despite the presentation and the response to treatment being different. AC and hidradenitis suppurativa (HS) resemble each other; a subtype of HS called “conglobata phenotype” has recently been reported in a large Dutch cohort. Acne vulgaris and HS are often associated. Isotretinoin is typically...

... were the same as in acne vulgaris. Acne’s phenotype was at least severe (including acne fulminans, nodulocystic and severe) in 83% of cases. Genetic mutations or variants with potential pathological significance were reported in 49 patients. The addition of isotretinoin to biotherapies was required...

...Elizabeth Tkachenko; Priyank Sharma; Arash Mostaghimi Background: Treatment modification and clinical course for patients initiating isotretinoin with abnormal baseline lab results is currently unknown, and no recommendations exist for monitoring this patient group. Methods: We performed...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hidradenitis suppurativa Isotretinoin mTOR signalling FoxO1 We have read with great interest the paper...

...Kadriye Aydin; Fatma Çetinözman; Gonca Elcin; Duygu Yazgan Aksoy; Fatma Ucar; Bulent O. Yildiz Background/Aim: Isotretinoin, the drug of choice for severe acne, might be associated with a decrease in insulin sensitivity. Adiponectin is an adipose tissue-derived protein that increases insulin...

... therapeutic regimen of systemic isotretinoin and prednisolone following the recent concepts of acne pathogenesis and drug kinetics. Methods: A prospective case series was recruited over 15 years. Isotretinoin 0.5 mg/kg bw/d (0.25-0-0.25) and prednisolone 30 mg/d (10-10-10) were administered concomitantly...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hidradenitis suppurativa Isotretinoin Frictional furunculoid subtype I have read with interest the article by Huang and Kirchhof [ 1...

...Christina M. Huang; Mark G. Kirchhof Background: Hidradenitis suppurativa (HS) is a disease characterized by the development of painful, deep-seeded nodules and abscesses. Treatment guidelines include a combination of lifestyle, surgical, and medical interventions. Isotretinoin has not been...

...] and 3 non-RCTs on systemic isotretinoin, adapalene/BPO and azelaic acid. The results of adapalene versus vehicle/no treatment varied depending on the reported outcome. The ‘number of patients maintaining at least 50% improvement' counting inflammatory lesions/non-inflammatory lesions with adapalene...

...Ayse Serap Karadag; Zennure Takci; Derun Taner Ertugrul; Serap Gunes Bilgili; Ragip Balahoroglu; Mumtaz Takir Background: There are a limited number of studies investigating the side effects and effectiveness of various doses of isotretinoin (ISO). We have previously shown that high-dose ISO...

...Ayse Serap Karadag; Derun Taner Ertugrul; Zennure Takci; Serap Gunes Bilgili; Mehmet Namuslu; Naim Ata; Ramazan Sekeroglu Background: The effect of isotretinoin (ISO) on adipokines and insulin resistance has been investigated in a few studies, and the results are conflicting. Objective: The aim...

...Anick Bérard; Laurent Azoulay; Hamid Reza Nakhai-Pour; Krystel Moussally Background: Case reports suggest that isotretinoin use is associated with an increased risk of cardiovascular disorders; however, the clinical significance has not been determined. Objective: To determine whether isotretinoin...

.... Since isotretinoin is very effective in the treatment of the nodular cystic acne but has been shown to increase blood lipid levels, we decided to compare its clinical effectiveness and its effects on lipid metabolism with those of minocycline in patients with nodular cystic acne. After 20 weeks...

...M. Harms; I. Masouyé; B. Radeff 89 patients (66 males and 23 females) with severe acne were treated with isotretinoin and were followed up for a period of 6–47 months (mean 14 months) after the end of the therapy. Relapses occurred in 14.6% of the patients. They were not found to be related...

...L. De Raeve; M. Willemsen; A. De Coninck; D. Roseeuw This paper reports on the association of two uncommon side effects of isotretinoin therapy for cystic acne: paronychia and excess granulation tissue in the nail sulci. An explanation for these side effects is suggested, but the exact pathogenesis...

...P.D. Pigatto; A. Fioroni; F. Riva; M.A. Brugo; A. Morandotti; G.F. Altomare; A.F. Finzi The authors show that the use of Isotretinoin (Ro 4–3740) in cystic acne brings a reduction of chemotactic activity of the neutrophil granulocytes, like another retinoid, Etretinate, in pustular and vulgar...

...H.L.M. van der Meeren; J.G. van der Schroeff; T. Stijnen; J.A. van Duren; H.A.C. van der Dries; P.C. van Voorst Vader 58 male patients with therapy-resistant conglobate acne were randomly selected for treatment with isotretinoin 1.0 or 0.5 mg/kg bodyweight. 27 patients received the high-dose...

...Philippe Berbis; Eliane Jancovici; Georges Lebreuil; Thierry Benderitter; Louis Dubertret; Yvan Privat The case of a 30-year-old man with a 6-year history of eosinophilic pustular folliculitis (EPF) is reported. Isotretinoin (1 mg/kg/day) led to a dramatic improvement of all the lesions within 2...

...Gary L. Peck Two patients with multiple basal cell carcinomas, due either to the nevoid basal cell carcinoma syndrome (NBCCS) or arsenical insecticide exposure, were treated with oral isotretinoin for 7 or 8 years, respectively. Gradually decreasing dosage levels were employed. During the initial...

...W.J. Cunliffe; J.F.B. Norris Isotretinoin is of undisputed benefit in the treatment of acne. In doses of 1 mg/kg/day for 4 months the drug produces a highly significant reduction in sebum excretion rate (90 ± 3%) in comedone formation as measured by assessing follicular casts (70 ± 5...