...Howard I. Maibach This paper reviews the percutaneous penetration of corticosteroids in vivo in man utilizing urinary excretion of 14 C-hydrocortisone as the experimental method. In general corticosteroids are only minimally absorbed from most areas of glabrous skin. Increasing the amount...

.... Raab and B. G meiner Vienna University Medical School, Department of Medical Chemistry (Chairman: Dr. E. K aiser), Vienna Key Words. Econazole Hydrocortisone Triamcinolone acetonide Yeasts Staphylo­ cocci Drug interactions Abstract. Econazole is a broad-spectrum antimicrobic substance which...

... acid to the dorsal ear surface of guinea pigs produced a progressive psoriasiform scaling which was apparent grossly and which could be quantitated. Triamcinolone acetonide, hydrocortisone and methotrexate, all known to be useful clinically in the treatment of psoriasis, were examined for their ability...

...R.L.J. Mertens; J.M. Morias; G. Verhamme In a 4-week double-blind trial, Daktacort® cream was compared with each of its constituents (i.e. miconazole 2% and hydrocortisone 1%) in a total of 63 patients (aged 12–60 years) with inflamed skin infections of bacterial or mycotic origin. Daktacort...

...R.H. Marten; J.P.H. Byrne; S. Peiris; J. Butler; J. Keenan This study compares the effects on the hypothalamo-pituitary adrenal (HPA) axis of two dosage schedules of hydrocortisone 17-butyrate and hydrocortisone ointments in 20 children suffering from eczema. Children with moderately extensive...

...W. Wohlrab; J. Lasch The applicability of liposomal hydrocortisone (HC) as a selective drug delivery system for cutaneous administration of glucocorticoids has been studied. With the liposomal form, a considerably better concentration-time profile was obtained in the individual layers of human skin...

.... ionophore-induced cornified envelope formation, was inhibited by various retinoids and stimulated by hydrocortisone. Retinoids that caused a significant reduction of cornified envelope formation, i.e. retinoic acid and 13- cis -retinoic acid, caused only minor changes in lipid synthesis and plasma membrane...

...Henning Schmidt; Niels Hjorth; Per Holm Thirty-nine patients with mainly psoriasis vulgaris and atopic dermatitis were treated for 4 weeks with 0.1% domoprednate and hydrocortisone butyrate ointment according to a right-left, randomized design. Various assessments of efficacy only revealed marginal...

...K.C. Moon; R.C. Wester; H.I. Maibach We observed hydrocortisone and benzoic acid absorption in relation to experimentally induced in vivo damaged skin models in the hairless guinea pig. Radioactivity of the drugs in urine was calculated as absorbed dose. Both drugs have different patterns...