...Pauline M. Dowd; M. Whitefield; M.W. Greaves Hexyl nicotinate in a lotion formulation was applied topically to the skin of 10 healthy volunteers with clinically normal skin. Erythematous responses were assessed visually and skin blood flow determined by means of a laser Doppler flow meter which...

... of hexyl nicotinate improved on the glycerol-treated areas. A direct physicochemical protection effect on the surface of the skin was ruled out in additional studies using NaOH and DMSO. Conclusions: Under the given conditions glycerol leads to a more rapid reconstitution of the protective skin barrier...