...P.D. Mier; José J.M.A. van den Hurk The use of synthetic fluorogenic substrate has been applied to the measurement of lipase from guinea pig epidermis. The enzyme is not inhibited by Triton X-100 in concentrations up to 2 mg/ml, has a pH optimum in the range 6.5–8.5, a Km of 1.0 × 10 –– 6 mol/l...

...Anders Boman; Jan E. Wahlberg; Gun Johansson Solvents were administered into closed skin depots on guinea pigs and the resulting blood concentrations were measured in samples repeatedly obtained via a catheter in the carotid artery. The exposure areas were protected with glove membranes...

...R. Brun; P. Laugier The nipples of male tan guinea pigs were used to test the effects on the skin of oral contraceptive pills and drugs. The daily topically applied doses were 1/2,000 of a pill. After 3 weeks, the nipples treated with solutions of ethinyloestradiol-containing pills had grown (200...

...Veronica Groh; Jürg Ch. Meyer; Renato Panizzon; Claudia Zortea-Caflisch This report defines the influence of field soft X-ray irradiation on the integrity of epidermal Langerhans cells (LC) in the guinea pig and mouse systems. Male albino (Rockefeller strain) and piebald F1 (2 ×13 strain) guinea...

...Takeshi Kambara; Junji Tsuruta; Tetsuro Yamamoto A newly discovered macrophage-chemotactic factor (MCFS-1) was extracted and purified (488-fold) from skin sites of guinea pigs showing delayed hypersensitivity to bovine γ-globulin. MCFS-1 is a heat-labile glycoprotein with a molecular weight...

...K.C. Moon; R.C. Wester; H.I. Maibach We observed hydrocortisone and benzoic acid absorption in relation to experimentally induced in vivo damaged skin models in the hairless guinea pig. Radioactivity of the drugs in urine was calculated as absorbed dose. Both drugs have different patterns...