...Gun-Britt Löwhagen; Gerd Michaëlsson; Håkan Mobacken; Ulf Pettersson; Anders Vahlquist The effect of the aromatic retinoid, etretinate, has been evaluated in 17 patients suffering from moderate to severe Darier’s disease (DD). The erythema, hyperkeratosis and number of papules as well...

...Jørgen V. Christiansen; Per Holm; Rigmor Møller; Flemming Reymann; Henning Schmidt A randomized trial with 146 psoriatic patients studied the relative merits of (1) oral etretinate (daily dose approximately 1 mg/kg body weight); (2) 0,1% betamethasone valerate cream twice daily, and (3...

...P.C.M. van de Kerkhof We present the first report of the management of generalized pustular psoriasis (Zumbusch pattern) in a young child with etretinate (Tigason). Striking features were the low dosage required to control the disease (as little as 10 mg per week) and the eventual transition...

... are the common features. Erythema of the nose, cheeks, and the perioral area in 4 affected members, actinic elastosis in 2 severely affected members, and partially impaired cell-mediated immunity in vitro in both affected and unaffected members are notable findings. Tigason (etretinate) treatment was beneficial...

...H. Wolska; S. Jabłonska; A. Langner; M. Fraczykowska Etretinate therapy in 18 cases of generalized pustular psoriasis of the Zumbusch type proved to be effective and the therapy of choice. Only in 4 patients was maintenance therapy needed; in most cases relapses occurred after various intervals...

...M. Gilbert; C.N. Ellis; J.J. Voorhees We prospectively analyzed radiographic skeletal surveys of eight patients who received etretinate therapy for psoriasis at doses ranging from 0.5 to 1.2 mg/kg/day for 6–18 months. Although subtle skeletal changes could have been obscured by some of our patients...

... of the hands remains discrete. Examination for contact allergy, fungal tests, vitamin A serum levels, and sex hormones were negative or normal in all the 10 patients. Microscopy revealed a lichenified eczema with evidence of mechanical irritation. Etretinate (0.78 mg/kg/day) brought about partial or total...

...Lutz Kowalzick; Hartwig Mensing In a patient suffering from benign lesions of epidermodysplasia verruciformis due to human papillomavirus type 5 little clinical improvement could be observed after 6 months of oral etretinate. The drug was given 75 mg/day for 1 month before dosage was reduced to 50...

...Hans-Iver Beck; Erik K. Foged A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year-old woman. The patient had received methotrexate alone for more than 10 years without any signs of severe liver...

...P.C. van Voorst Vader; H.J. Houthoff; H.F. Eggink; C.H. Gips A histologically confirmed, clinically inapparent and reversible hepatitis occurred in 2 patients (1 psoriasis, 1 basal cell nevus syndrome) within the first months after introduction of etretinate therapy. Causes of hepatitis other than...

...Jørgen V. Christiansen; Per Holm; Flemming Reymann; Kristian Thestrup-Pedersen From January 1976 to April 1982 etretinate was used to treat patients with morbus Darier (25 patients), pustulosis palmo-plantaris (72 patients), psoriasis (79 patients), and hyperkeratotic eczema of hands and feet...

...A.L. Claudy; O. de Bouteiller; J.L. Touraine Trimethylmethoxyphenyl-retinoic acid (TMMPRA), the main active therapeutic form of etretinate, was used for in vitro studies on human lymphocytes. Lymphocyte DNA synthesis remained unchanged when TMMPRA was added to the cultures at a concentration range...

...Erik Foged; Per Holm; Poul Ølholm Larsen; Grete Laurberg; Flemming Reymann; Kresten Roesdahle; Susanne Ullman 50 patients with palmoplantar pustulosis (PPP) were randomized to 8 weeks of daily treatment with either oral etretinate, 1 mg/kg b.w. or placebo. Good or moderate effect was obtained in 18...

...A. Lassus; J. Lauharanta; T. Juvakoski; L. Kanerva A total of 40 patients with palmoplantar pustulosis (PPP) were initially treated with oral etretinate (Tigason) in an open trial with a maximum treatment period of 16 weeks. Remission, with only slight residual changes in some cases, was achieved...

...F. Ott; Y. Bounameaux Ro12–7554, a chlorinated derivative of etretinate, was evaluated in an open study. 16 patients, 13 suffering from severe psoriasis and 3 from congenital disorders of keratinization previously treated with etretinate, received Ro 12–7554 at a mean daily dosage of 12.3 mg/day...

...C.J. Brindley Following oral administration of acitretin with food, peak plasma concentrations of unchanged drug (Ro 10-1670) are reached within 4 h. The mean absolute bioavailabihty of acitretin is 59% with high interpatient variability consistent with that of etretinate. Taking acitretin...

...Gustav Mahrle; Bernd Thiele Sixteen patients – 12 with cutaneous T cell lymphoma (CTCL), 1 with Sézary syndrome, 1 with actinic reticuloid, and 2 with parapsoriasis variegata – were treated with either a new, potent arotinoid alone or with combined etretinate (Tigason®) and PUVA therapy (Re-PUVA...

... of the epitheliomata is successful but time consuming. X-irradiation should not be used, but cryotherapy of early lesions is helpful. One patient, treated with etretinate for 24 months, has developed only 8 epitheliomata over this time, compared with 23 in the previous 24 months. Etretinate therefore appears...

...Antonella Tosti; Patrizia Manuzzi; Federico Bardazzi; Angela Costa A 23-year-old girl affected by Papillon-Lefèvre syndrome developed, during Etretinate therapy (1 mg/kg/day), two liver abscesses caused by pyogenic bacteria and a subphrenic abscess. The immunological effects of retinoids may...

... violet A photochemotherapy (PUVA) of severe psoriasis decrease the UVA energy required to achieve remission, and (2) is there a difference between two retinoids, i.e. etretinate and acitretin. Acitretin-PUVA treatment was significantly superior to placebo-PUVA with respect to several items (decrease...