... candidate for the treatment of keloids. Keloids Antimicrobial peptides Therapy Collagen Dear Editor, Keloids are traditionally viewed as benign fibroproliferative scars with aggressive dermal growth that extend outside the borders of the original wound or injury owing to excessive...

...Yoorock Suh; Jungyoon Moon; Ji Young Yoon; Soo Woong Kim; Yu Sung Choi Background: Diabetes damages the collagen in the skin. No study has investigated the relationship between the treatment initiation time and the degree of collagen recovery. This study aimed to evaluate the effects...

... of rat with age. Key Words Skin Amine oxidase C-tyramine Connective tissue BAPN Penicillamine Collagen Amine oxidases are enzymes responsible for metabolism of various amines in the body. They are present in most mammalian tissues and their pro­ perties vary in different tissues. The intracellular...

...R. Laurent; P. Agache An ultrastructural study of the dermis in a case of acrogeria is presented and compared with a healthy control of same age and sex. The overgrowing orceinophil material was mainly pseudoelastic. The collagen was hypoplastic and mostly immature. Inside and outside...

.... Treatment of basement membranes with pepsin at low temperature digests the noncollagenous glycoprotein components and allows the collagenous component to come into solution. Purification of the pepsin-solubilized collagen from basement membranes reveals a molecule composed of three identical α-chains. Other...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Collagen Cross links Age-changes in human dermis Dermatológica 155: 335-339 (1977) Age-Related Changes in the Reducible Cross-Links of Human...

...D. Volpin; Pasquali Ronchetti; I. Castellani; M.G. Giro; A. Peserico; G. Mori Ultrastructural and biochemical studies on the collagen and elastin fibres of the dermis from a patient with Elastosis perforans serpiginosa are described. Qualitative and quantitative alterations on collagen and elastin...

... exhibiting altered affinity for the electron microscopical stains and altered ultrastructural organization. In the most affected patient the elastin was shown to be increased and to have an abnormal amino acid composition. In some patients the collagen fibers were laterally fused. The ground substance...

... to in the content or advertisements. Prolidase Peptidase Collagen Imidodipeptides Ulcers Original Papers Originalarbeiten Travaux originaux Dermatologica 164: 293-304 (1982) Prolidase Deficiency: An Inborn Error of Metabolism with Major Dermatological Manifestations Vazken M. Der Kaloustiana, Bishara J...

...-hypodermal plexus, the paraseptal plexus or in the fasciae. Secondary sclerosis resulted from the lateral fusion of bundles of collagen fibers. Three degrees of intensity of sclerosis were disclosed by our noninvasive technique of tonometry by vertical traction of the skin in vivo. That measurement allowed...

...Akira Konohana; Shunichi Miyakawa; Shingo Tajima; Takeji Nishikawa Biochemical analysis of involved and uninvolved skin of a 16-year-old female with acrogeria showed that hyaluronic acid and collagen contents were decreased only in involved skin. Explant cultures from both involved and uninvolved...

.... Histologically, the epidermis was flattened, dermis thinned and the connective tissue densely packed with very few cellular elements. Electron microscopic examination revealed partially abnormal collagen fibers with varying caliber, degenerated elastic fibers and dystrophic fibroblasts. The patient’s fibroblasts...

... by flow cytometry to detect a possible heterogeneity of scleroderma fibroblast cultures which could explain the production of excessive amounts of collagen. No evidence of a subpopulation responsible for elevated collagen production was detected using cytoplasmic dot hybridization of cells fractionated...

...M. Fartasch; E. Haneke; O.P. Hornstein The ultrastructural morphology of localized skin calcifications without associated diseases and with normal serum calcium and phosphate ion values is still unknown. In a case of superficial dystrophic calcinosis cutis (DCC) the role of collagen elastin...

...S. Tajima; H. Yamada Background : The main clinical symptoms of systemic scleroderma are caused by an accumulation of collagen in the tissues. Familial scleroderma is a very rare disorder in which systemic scleroderma occurs in the members of the same family. Objective : To know whether...

... to the regulation operated by the extracellular matrix and mechanical forces. Conclusion: In vitro MF display a phenotype that differentiates them from DF and SMC. Myofibroblasts Fibroblasts Smooth muscle cells Cell culture Contraction Cytoskeleton Collagen Collagenase Dermatology 1994;189(supp! 2):65...

...J.D. Chen; M. Helmold; J.P. Kim; K.C. Wynn; D.T. Woodley The migration of human keratinocytes is dramatically influenced by the type of extracellular matrix in contact with the cells: collagen induces the cells to produce long, linear migration tracks. In this study, a migration assay and computer...

... result in incorrect diagnosis and treatment. Microscopic studies of the lesions show the typical findings of dystrophic EB associated with an unusually high density of collagen bundles and absence of elastic fibres in the upper dermis. Itching lichenoid lesions of EB pruriginosa could represent...

... studied the effects of PenG on dermal fibroblasts by analysing the influence of various amounts of PenG on the proliferation, synthesis and degradation of collagen by human dermal fibroblasts from healthy donors and 1 SSc patient (collagen high producer). Methods: Collagen metabolism of cultured dermal...

...Z. Ruszczak; R.A. Schwartz Collagen-derived materials have been used in medicine for many decades. Sutures, hemostatic devices and matrices which stimulate cell growth and soft tissue augmentation are the major applications. In this update, we discuss the two major applications for collagen...