...Teng-Li Lin; Ching-Min Kuo; Yi-Ling Chang; Hsiu J. Ho; Yi-Ju Chen; Chun-Ying Wu Background: Acitretin has been linked to the development of psychiatric disturbance. Objectives: The aim of this study was to assess the psychiatric hazards in patients with psoriasis prescribed acitretin compared...

...-bearing areas of the skin. Approved treatments include antibiotics and biologic drugs such as adalimumab. Despite these treatments, HS management is challenging. Acitretin is an oral retinoid used for its management as 3rd or 4th line therapy. There is little evidence regarding the effectiveness...

... retrospective chart review of patients receiving FAEs was performed. Results: A total of 17 cases of patients receiving FAEs combined with at least one other systemic therapy (methotrexate, acitretin, etanercept, cyclosporine, leflunomide and infliximab) to treat psoriasis or psoriatic arthritis were identified...

... however. Achievement of complete response was obtained with ustekinumab 90 mg s.c. every 12 weeks combined with acitretin; the plasma level of IL-1β concomitantly returned to normal. This case report is associated with a review on recent data on ACH treatment with biological agents, including anakinra...

...Ayse Serap Karadag; Derun Taner Ertugrul; Goknur Kalkan; Serap Gunes Bilgili; Huseyin Tugrul Celik; Zennure Takci; Ragıp Balahoroglu; Omer Calka Background/Aim: To investigate the effects of acitretin treatment on insulin resistance (IR) and adipokines, particularly retinol-binding protein (RBP)-4...

.... Fortunately her symptoms were resolved with the treatment of antibiotics and acitretin, and at day 60 postpartum her skin lesions had completely disappeared. Conclusion: Although IH is associated with high mortality and morbidity in both fetus and mother, a better prognosis could be achieved with an immediate...

... resolution of GPP, the mechanism of action of these agents remains to be investigated. Here, we sought to evaluate markers of immune response in the skin of a patient who experienced a rapid amelioration of GPP after treatment with infliximab and acitretin. Methods: A skin biopsy was obtained before and 72 h...

...C.J. Brindley Following oral administration of acitretin with food, peak plasma concentrations of unchanged drug (Ro 10-1670) are reached within 4 h. The mean absolute bioavailabihty of acitretin is 59% with high interpatient variability consistent with that of etretinate. Taking acitretin...

...P. Berbis; J.-M. Geiger; C. Vaisse; C. Rognin; Y. Privat The purpose of this double-blind study was to compare the therapeutic effects of a low initial dosage of acitretin, increased at 2-week intervals (group 1:10, 30, 50 mg/day) with a high initial dosage decreased at similar intervals (group 3...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Interleukin 1α Interleukin 1β Immunoblot Enzymoimmunoassay Acitretin...

...J.-M. Geiger; B.M. Czarnetzki Acitretin (Ro 10-1670, etretin) is the free acid derivative of etretinate. This compound possesses a much shorter half-life of elimination than etretinate and was therefore proposed for clinical development. A total of 635 patients with various dermatoses were studied...

...P. Berbis; H. Bun; N.R. Al Mallah; A. Durand; C. Rognin; J.M. Geiger; Y. Privat In order to study the elimination of Ro 10-1670 (acitretin) and Ro 13-7652, its 13-cis-isomeric metabolite after chronic administration, determination of the residual plasma concentrations of these two compounds were...

... violet A photochemotherapy (PUVA) of severe psoriasis decrease the UVA energy required to achieve remission, and (2) is there a difference between two retinoids, i.e. etretinate and acitretin. Acitretin-PUVA treatment was significantly superior to placebo-PUVA with respect to several items (decrease...

...D. Hartmann; H. Mosberg; W. Weber A possible influence of the aromatic retinoid acitretin on the hypothrombinemic action of phenprocoumon was investigated in 10 healthy male volunteers, 22–33 years of age. In a run-in period of 17 days the prothrombin complex activity (Quick) of the subjects...

...D. Hohl; F. Pelloni; C. Sigg; S. Gilardi; T. Jung We prospectively analyzed skeletal changes of 16 patients who were treated with acitretin for various disorders of keratinization at doses of 10–50 mg/day (overall mean 0.4 mg/kg/day) for 7–12 months (mean 11.4 months). Skeletal changes from...

...P.C.M. van de Kerkhof; P.M. Steijlen; R.J. van Dooren-Greebe; R. Happle A patient with erythrokeratodermia variabilis (Mendes da Costa’s disease) is presented, and the clinical and histological response to acitretin is described. An initial dose of 35 mg of acitretin and a maintenance dose of 25–35...

.... Psoriasis Birdshot chorioretinopathy Retinoids Acitretin Ocular side effects Case Report Dermatology 1993; 187:137-139 S. Hes.se' Ph. Berbisa J.F . Chemila' Y. Privâta Clinique Dermatologique et Service d'Ophtalmologie, Hôtel-Dieu. Marseille, France Psoriasis and Birdshot Chorioretinopathy: Response...

...J.-M. Geiger; M. Baudin; J.-H. Saurat Etretinate (Tigason®, Tegison®) and its active metabolite acitretin (Neotigason®, Soriatane®) are known teratogens. Pregnancy should be avoided during treatment and until 2 years after treatment discontinuation. The question is discussed whether a dose...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acitretin Side-effects Rectal bleeding Discoid lupus erythematosus Correspondence and Opinions In this issue Rectal...

...J.-M. Geiger; M. Walker Review of preclinical data including genotoxicity assays and a male rat reproduction toxicology study demonstrates that acitretin (Neotigason ® /Soriatane ® ) does not affect the reproductive outcome in naive females mated with treated males. Prospective studies...