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First page of A retrospective study of nevus-associated melanoma in situ

Introduction: The frequency and type of nevus association in histology in melanoma in situ (MIS) is unclear. Methods: We performed a retrospective study to investigate the characteristics, frequency and type of adjacent nevus in histology (common or dysplastic) in MIS. Lentigo maligna (LM) and in situ acral lentiginous melanomas (ALM) were excluded. Results: From 1991 to 2023, there were 448 available non-lentigo maligna/non-ALM MIS. MIS were nevus-associated (NAM-MIS) in 353 cases (79%). Of these cases, 326 NAM-MIS (94%) had dysplastic nevus remnants. Among the dysplastic nevus-MIS, 176 (54%) were adjacent with severely dysplastic nevus. Nevus-associated MIS vs de novo MIS were more frequently located on the trunk (54% vs 36%), and less frequently located on the head/neck (8% vs 11%) (p=0.02). Conclusions: Nevus association is a common finding in MIS and almost all of nevus-associated MIS were associated with a dysplastic nevus. These findings may indicate an evolution from severely dysplastic nevus to MIS, and also reflect the equivalent histopathological classification and support their previously proposed biological equivalence as not obligate precursors of invasive melanomas.

Journal Section:
Skin Cancer
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S. Karger AG, Basel
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2025
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