Background: Acute guttate psoriasis (AGP) is a distinctive clinical entity with good response to treatment with narrow-band ultraviolet B (NB-UVB). Objective: To investigate the results of NB-UVB phototherapy in adult patients with adult guttate psoriasis. Material and Methods: We carried out a prospective, open, and observational study. Patients over 18 years with more than 5% of body surface area affected were included. The PASI was assessed prior to and after treatment. The follow-up period was 18 months. After treatment, patients completed a simple questionnaire to assess their overall impression of the treatment. Results: The 67 adult patients with AGP included in this study had an initial PASI of 8.55 (SD 5.03). Patients were treated with a mean of 19.9 sessions (SD 13.5) and mean doses of 14 mJ/cm2 (SD 10.5). Of the 67 patients, 52 achieved PASI90 with 96.15% of PASI reduction, and of these, 46 (88%) maintained PASI90 during the 18 months of follow-up. Patients were very satisfied with the treatment. Discussion: AGP is a defined clinical entity with a variable course. Phototherapy with NB-UVB appears to be a very good option for treatment of AGP because of the good results obtained and patient satisfaction.

Griffiths CE, Christophers E, Barker JN, et al: A classification of psoriasis vulgaris according to phenotype. Br J Dermatol 2007;156:258-262.
Takahashi H, Nakamura K, Kaneko F, Nagakawa H, Lizuka H: Analysis of psoriasis patients registered with the Japanese society for psoriasis research from 2002-2008. J Dermatol 2011;38:1125-1129.
Nahary L, Tamarkin A, Kayam N, et al: An investigation of antistreptococcal antibody responses in gutatte psoriasis. Arch Dermatol Res 2008;30:441-449.
De Jager MEA, de Jong EMGJ, Meeuwis KAP, van de Kerkhof PCM, Seyger MMB: No evidence found that childhood onset of psoriasis influences disease severity, future body mass index or type of treatments used. J Eur Acad Dermatol 2010;24:1333-1339.
Ko HC, Jwa SW, Song M, Kim MB, Kwon HS: Clinical course of guttate psoriasis: long-term follow-up study. J Dermatol 2010;37:894-899.
Manolache L, Petrescu-Sceleanu D, Benea V: Life events involvement in psoriasis onset/recurrence. Int J Dermatol 2010;49:636-641.
Almutawa F, Alnomair N, Wang Y, Hamazavi I, Lim HW: Systematic review of UV-based therapy for psoriasis. Am J Clin Dermatol 2013;14:87-109.
Chen X, Yang M, Cheng Y, Liu GJ, Zhang M: Narrow-band ultraviolet B phototherapy versus broad-band ultraviolet B or psoralen-ultraviolet A photochemotherapy for psoriasis. Cochrane Database Syst Rev 2013;10: CD009481.
Carrascosa JM, López-Estebaranz JL, Carretero G, et al: Documento de consenso de fototerapia en la psoriasis del Grupo Español de Psoriasis: ultravioleta B de banda estrecha (UVBBE), láser y fuentes monocromáticas de excímeros y terapia fotodinámica. Actas Dermosifiliogr 2011;102:175-186.
Gokdemir G, Kivanç-Altunay I, Koslu A: Narrow-band phototherapy in patients with psoriasis: for which types of psoriasis is it more effective? J Dermatol 2005;32:436-441.
Carvalho R, Marques-Pinto G, Cardoso J: Psoriasis phototherapy experience from a Lisbon unit: a still valid therapeutic approach in the 21st century. Cutan Ocul Toxicol 2013;32:78-82.
Chalmers RJ, O'Sullivan T, Owen CM, Griffiths CE: Interventions for guttate psoriasis. Cochrane Database Syst Rev 2000;2: CD001213.
Pathirana D, Ormerod AD, Saiag P, et al: European S3-guidelines on the systemic treatment of psoriasis vulgaris. J Eur Acad Dermatol Venereol 2009;23:1-70.
Cameron H, Dawe RS, Yule S, et al: A randomized, observer-blinded trial of twice vs three times weekly narrow band ultraviolet B phototherapy for chronic plaque psoriasis. Br J Dermatol 2002;147:973-978.
Behrens S, Grundmann-Kollmann M, Schiener R, et al: Combination phototherapy of psoriasis with narrow-band UVB irradiation and topical tazarotene gel. J Am Acad Dermatol 2000;42:493-495.
Brands S, Brankman M, Bos J, et al: No additional effect of calcipotriol ointment on low-dose narrow-band UVB phototherapy in psoriasis. J Am Acad Dermatol 1999;41:991-995.
Kirke SM, Lowder S, Lloyd JJ, et al: A randomized comparison of selective broadband UVB and narrowband UVB in the treatment of psoriasis. J Invest Dermatol 2007;127:1641-1646.
Boztepe G, Karaduman A, Sahin S, Hayran M, Kolemen F: The effect of maintenance narrow-band ultraviolet B therapy on the duration of remission for psoriasis: a randomized trial. Int J Dermatol 2006;45:245-250.
Puig L, Carrascosa JM, Carretero G, et al: Directrices basadas en la evidencia para el tratamiento de la psoriasis con fármacos biológicos 2013. Actas Dermosifiliogr 2013;104:694-709.
Martin BA, Chalmers RJ, Telfer NR: How great is the risk of further psoriasis following a single episode of acute guttate psoriasis? Arch Dermatol 1996;132:717-718.
Ferrandiz C, Pujol RM, Garcia-Patos V, et al: Psoriasis of early and late onset: a clinical and epidemiologic study in Spain. J Am Acad Dermatol 2002;46:867-873.
Williams RC, McKenzie AW, Roger JH, Joysey VC: HL-A antigens in patients with guttate psoriasis. Br J Dermatol 1976:95:163-167.
Mallbris L, Larsson P, Bergqvist S, et al: Psoriasis phenotype at disease onset: clinical characterization of 400 adult cases. J Invest Dermatol 2005;124:499-504.
Naldi L, Peli L, Parazzini F, Carrel CF: Family history of psoriasis, stressful life events, and recent infectious disease are risk factors for a first episode of acute guttate psoriasis: results of a case control study. J Am Acad Dermatol 2001;44:433-438.
Nahary L, Tamarkin A, Kayam N, et al: An investigation of antistreptococcal antibody responses in gutatte psoriasis. Arch Dermatol Res 2008;30:441-449.
Dogan B, Karabudak O, Harmanyeri Y: Antistreptococcal treatment of gutatte psoriasis: a controlled study. Int J Dermatol 2008;47:950-952.
Finch T, Shim TN, Roberts L, Johnson O: Treatment satisfaction among patients with moderate to severe psoriasis. J Clin Aesthet Dermatol 2015;8:26-30.
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