Intravascular large B-cell lymphoma (IVL) is a rare subtype of extranodal malignant lymphoma. The proliferation of neoplastic B cells within small blood vessels causes eruptions and other symptoms in a variety of organs. The random skin biopsy is useful for diagnosing this condition in its early stages. In order to assess the diagnostic utility of this method, we examined 3 cases with the aim of comparing the occurrence of tumor cells in lesional and healthy-looking skin by performing a random skin biopsy of 32 separate sites. Our findings from the total of 32 biopsy specimens collected from the 3 cases indicated that 16 of the 17 sites on the lesional skin and 1 of the 15 sites on the healthy-looking skin were positive for neoplastic cells. This finding suggested that IVL cells occurred more frequently in the lesional skin than in the healthy-looking skin.

Eros N, Karolyi Z, Kovacs A, et al: Intravascular B-cell lymphoma. J Am Acad Dermatol 2002;47:s260-s262.
Pfleger L, Tappeiner J: On the recognition of systematized endotheliomatosis of the cutaneous blood vessels. Hautarzt 1959;10:359-363.
Matsue K, Asada N, Odawara J, et al: Random skin biopsy and bone marrow biopsy for diagnosis of intravascular large B cell lymphoma. Ann Hematol 2011;90:417-421.
Kinoshita M, Izumoto S, Hashimoto N, et al: CNS lymphomas: a study comparing primary CNS malignant and CNS intravascular lymphomas. Brain Tumor Pathol 2008;25:73-78.
Gill S, Melosky B, Haley L, et al: Use of random skin biopsy to diagnose intravascular lymphoma presenting as fever of unknown origin. Am J Med 2003;114:56-58.
Asada N, Odawara J, Kimura S, et al: Use of random skin biopsy for diagnosis of intravascular large B-cell lymphoma. Mayo Clin Proc 2007;82:1525-1527.
Lydia D, Aissatou S, Christine D, et al: A blind skin biopsy diagnosing an intravascular large B-cell lymphoma. Eur J Dermatol 2011;21:114-115.
Murase T, Nakamura S, Kawauchi K, et al: An Asian variant of intravascular large B-cell lymphoma: clinical, pathological and cytogenetic approaches to diffuse large B-cell lymphoma associated with haemophagocytic syndrome. Br J Haematol 2000;111:826-834.
Zuckerman D, Seliem R, Hochberg E, et al: Intravascular lymphoma. Oncologist 2006;11:496-502.
Narimatsu H, Morishita Y, Saito S, et al: Usefulness of bone marrow aspiration for definite diagnosis of Asian variant of intravascular lymphoma: four autopsied cases. Leuk Lymphoma. 2004;45:1611-1616.
Shimada K, Matsue K, Yamamoto K, et al: A retrospective analysis of intravascular large B-cell lymphoma treated with rituximab-containing chemotherapies. J Clin Oncol. 2008;26:3189-3195.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.