Background: Targetoid hemosiderotic hemangioma is an uncommon, vascular, benign solitary lesion of lymphatic origin that can be misdiagnosed as other tumors including melanomas. Objectives: To evaluate the dermoscopic features of a large series of targetoid hemosiderotic hemangiomas. Methods: Digital dermoscopic images of 35 histopathologically confirmed cases of targetoid hemosiderotic hemangiomas collected from 7 hospitals in Spain and Italy were evaluated for the presence of dermoscopic structures and patterns. Results: The results of our study reveal that the presence of central red and dark lacunae and a peripheral circular reddish-violaceous homogeneous area is the most common dermoscopic pattern in targetoid hemosiderotic hemangioma (71.4%). The targetoid hemosiderotic hemangiomas of our study were correctly diagnosed in 77% of cases. Conclusion: Dermoscopy is helpful in improving the diagnosis of targetoid hemosiderotic hemangioma. However, attention must be paid to those cases that dermoscopically may show nontargetoid patterns, which often mimic other lesions, including melanoma.

Mentzel T, Partanen TA, Kutzner H: Hobnail hemangioma (‘targetoid hemosiderotic hemangioma'): clinicopathologic and immunohistochemical analysis of 62 cases. J Cutan Pathol 1999;26:279-286.
Trindade F, Kutzner H, Tellechea Ó, Requena L, Colmenero I: Hobnail hemangioma reclassified as superficial lymphatic malformation: a study of 52 cases. J Am Acad Dermatol 2012;66:112-115.
Sahin MT, Demir MA, Gunduz K, Ozturkcan S, Türel-Ermertcan A: Targetoid haemosiderotic haemangioma: dermoscopic monitoring of three cases and review of the literature. Clin Exp Dermatol 2005;30:672-676.
Morales-Callaghan AM, Martinez-Garcia G, Aragoneses-Fraile H, Miranda-Romero A: Targetoid hemosiderotic hemangioma: clinical and dermoscopical findings. J Eur Acad Dermatol Venereol 2007;21:267-269.
Ertam I, Akalin T, Unal I, Ozdemir F: Hobnail haemangioma: dermatoscopic findings facilitating the differential diagnosis. Clin Exp Dermatol 2009;34:e231-e233.
Ghibaudo N, Lacour JP, Argenziano G, Ortonne JP, Bahadoran P: Fully regressive targetoid haemosiderotic haemangioma. J Eur Acad Dermatol Venereol 2009;23:722-723.
Piccolo V, Russo T, Mascolo M, Staibano S, Baroni A: Dermoscopic misdiagnosis of melanoma in a patient with targetoid hemosiderotic hemangioma. J Am Acad Dermatol 2014;71:e179-e181.
Zaballos P, Daufí C, Puig S, et al: Dermoscopy of solitary angiokeratomas: a morphological study. Arch Dermatol 2007;143:318-325.
Marghoob AA, Cowell L, Kopf AW, Scope A: Observation of chrysalis structures with polarized dermoscopy. Arch Dermatol 2009;145:618.
Moscarella E, Zalaudek I, Buccini P, Cota C, Catricalà C, Argenziano G: Dermoscopy and confocal microscopy of thrombosed hemangiomas. Arch Dermatol 2012;148:410.
Scalvenzi M, De Natale F, Francia MG, Balato A: Dermoscopy of microvenular hemangioma: report of a case. Dermatology 2007;215:69-71.
Mota A, Argenziano G, Zalaudek I, et al: Clinical, dermoscopic and histopathologic findings of retiform hemangioendothelioma. Dermatol Pract Concept 2013;31:11-14.
Zaballos P, Puig S, Llambrich A, Malvehy J: Dermoscopy of dermatofibromas: a prospective morphological study of 412 cases. Arch Dermatol 2008;144:75-83.
Zaballos P, Puig S, Malvehy J: Dermoscopy of pigmented purpuric dermatoses (lichen aureus): a useful tool for clinical diagnosis. Arch Dermatol 2004;140:1290-1291.
Menzies SW, Kreusch J, Byth K, et al: Dermoscopic evaluation of amelanotic and hypomelanotic melanoma. Arch Dermatol 2008;144:1120-1127.
Baroni A, Piccolo V: Images in clinical medicine: red melanoma. N Engl J Med 2013;368:1536.
Carlson JA, Daulat S, Goodheart HP: Targetoid hemosiderotic hemangioma - a dynamic vascular tumor: report of 3 cases with episodic and cyclic changes and comparison with solitary angiokeratomas. J Am Acad Dermatol 1999;41:215-224.
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