Background: Blue light irradiation reduces the proliferation of keratinocytes and modulates T-cell immune response in vitro and has been shown to reduce the severity of psoriasis vulgaris (Pv) in two clinical trials. Objective: Evaluation of safety and efficacy of long-term UV-free blue light treatment at home for mild Pv. Methods: Forty-seven patients with mild Pv were randomized for receiving high-intensity blue light treatment (HI: 453 nm LED, 200 mW/cm2, n = 24) and low-intensity treatment (LI: 453 nm LED, 100 mW/cm2, n = 23) of one Pv plaque for 12 weeks. A contralateral control plaque remained untreated. Results: Patient compliance and satisfaction were high. The primary endpoint, change from baseline (CfB) of the Local Psoriasis Severity Index, revealed a significant improvement of the target compared to the control plaques (ΔCfB for the HI group: -0.92 ± 1.10, p = 0.0005; for the LI group: -0.74 ± 1.18, p = 0.0064). Conclusion: UV-free blue light home treatment is safe and improves Pv plaques.

Keywords:
Clinical trial, Phototherapy, Psoriasis, Randomized clinical trials, Blue light, Clinical investigation, Light-emitting diode
1.
Schon MP, Boehncke WH: Psoriasis. N Engl J Med 2005;352:1899-1912.
2.
Lapolla W, Yentzer BA, Bagel J, Halvorson CR, Feldman SR: A review of phototherapy protocols for psoriasis treatment. J Am Acad Dermatol 2011;64:936-949.
3.
Mork C, Wahl A: Improved quality of life among patients with psoriasis after supervised climate therapy at the Canary Islands. J Am Acad Dermatol 2002;47:314-316.
4.
Pathak MA: Ultraviolet radiation and the development of non-melanoma and melanoma skin cancer: clinical and experimental evidence. Skin Pharmacol 1991;4(suppl 1):85-94.
5.
Liebmann J, Born M, Kolb-Bachofen V: Blue-light irradiation regulates proliferation and differentiation in human skin cells. J Invest Dermatol 2010;130:259-269.
6.
Becker D, Langer E, Seemann M, Seemann G, Fell I, Saloga J, Grabbe S, von Stebut E: Clinical efficacy of blue light full body irradiation as treatment option for severe atopic dermatitis. PLoS One 2011;6:e20566.
7.
Fischer MR, Abel M, Lopez Kostka S, Rudolph B, Becker D, von Stebut E: Blue light irradiation suppresses dendritic cells activation in vitro. Exp Dermatol 2013;22:558-560.
8.
Weinstabl A, Hoff-Lesch S, Merk HF, von Felbert V: Prospective randomized study on the efficacy of blue light in the treatment of psoriasis vulgaris. Dermatology 2011;223:251-259.
9.
Kleinpenning MM, Smits T, Frunt MH, van Erp PE, van de Kerkhof PC, Gerritsen RM: Clinical and histological effects of blue light on normal skin. Photodermatol Photoimmunol Photomed 2010;26:16-21.
10.
Kleinpenning MM, Otero ME, van Erp PE, Gerritsen MJ, van de Kerkhof PC: Efficacy of blue light vs. red light in the treatment of psoriasis: a double-blind, randomized comparative study. J Eur Acad Dermatol Venereol 2012;26:219-225.
11.
Goldberg DJ, Russell BA: Combination blue (415 nm) and red (633 nm) LED phototherapy in the treatment of mild to severe acne vulgaris. J Cosmet Laser Ther 2006;8:71-75.
12.
Strauss KA, Robinson DL, Vreman HJ, Puffenberger EG, Hart G, Morton DH: Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease. Eur J Pediatr 2006;165:306-319.
13.
Tullis T, Albert W: Measuring the User Experience: Collecting, Analyzing and Presenting Usability Metrics. San Francisco, Morgan Kaufmann, 2008.
14.
Bangor A, Kortum P, Miller JA: An empirical evaluation of the System Usability Scale. Int J Hum Comp Interact 2008;24:574-594.
15.
Fredriksson T, Pettersson U: Severe psoriasis - oral therapy with a new retinoid. Dermatologica 1978;157:238-244.
16.
Beck LA, Thaci D, Hamilton JD, Graham NM, Bieber T, Rocklin R, Ming JE, Ren H, Kao R, Simpson E, Ardeleanu M, Weinstein SP, Pirozzi G, Guttman-Yassky E, Suarez-Farinas M, Hager MD, Stahl N, Yancopoulos GD, Radin AR: Dupilumab treatment in adults with moderate-to-severe atopic dermatitis. N Engl J Med 2014;371:130-139.
17.
Mason AR, Mason J, Cork M, Dooley G, Hancock H: Topical treatments for chronic plaque psoriasis. Cochrane Database Syst Rev 2013;3:CD005028.
18.
Monfrecola G, Lembo S, Cantelli M, Ciaglia E, Scarpato L, Fabbrocini G, Balato A: The effect of visible blue light on the differentiation of dendritic cells in vitro. Biochimie 2014;101:252-255.
19.
Maari C, Viau G, Bissonnette R: Repeated exposure to blue light does not improve psoriasis. J Am Acad Dermatol 2003;49:55-58.
20.
Matichard E, Le Henanff A, Sanders A, Leguyadec J, Crickx B, Descamps V: Effect of neonatal phototherapy on melanocytic nevus count in children. Arch Dermatol 2006;142:1599-1604.
21.
Csoma Z, Hencz P, Orvos H, Kemeny L, Dobozy A, Dosa-Racz E, Erdei Z, Bartusek D, Olah J: Neonatal blue-light phototherapy could increase the risk of dysplastic nevus development. Pediatrics 2007;119:1269.
22.
Mahe E, Beauchet A, Aegerter P, Saiag P: Neonatal blue-light phototherapy does not increase nevus count in 9-year-old children. Pediatrics 2009;123:e896-e900.
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2015
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