Background: The antifungal activity of coriander oil has already been demonstrated in vitro. Objective: Evaluation of the efficacy and tolerability of 6% coriander oil in unguentum leniens in the treatment of interdigital tinea pedis. Methods: Half-side comparative pilot study on subjects with symmetric, bilateral interdigital tinea pedis. Active drug and placebo control were applied twice daily on the affected areas, and follow-up visits were performed on days 14 and 28. Results: 40 participants (mean age 52.5 years, 60% male) were included in the study. For 6% coriander oil in unguentum leniens, a highly significant improvement of the clinical signs (p < 0.0001) was observed during the entire observation period; the number of positive fungal cultures also tended to decrease (p = 0.0654). The tolerability of the tested substances was good. Conclusion: Coriander oil is effective and well tolerated in the treatment of interdigital tinea pedis.

Miklic P, Skerlev M, Budimcic D, Lipozencic J: The frequency of superficial mycoses according to agents isolated during a ten-year period (1999-2008) in Zagreb area, Croatia. Acta Dermatovenerol Croat 2010;18:92-98.
Augustin M, Herberger K, Hintzen S, Heigel H, Franzke N, Schaefer I: Prevalence of skin lesions and need for treatment in a cohort of 90,880 workers. Br J Dermatol 2011;165:865-873.
Weitzman I, Summerbell RC: The dermatophytes. Clin Microbiol Rev 1995;8:240-259.
Seebacher C, Bouchara JP, Mignon B: Updates on the epidemiology of dermatophyte infections. Mycopathologia 2008;166:335-352.
Foster KW, Ghannoum MA, Elewski BE: Epidemiologic surveillance of cutaneous fungal infection in the united states from 1999 to 2002. J Am Acad Dermatol 2004;50:748-752.
Borman AM, Campbell CK, Fraser M, Johnson EM: Analysis of the dermatophyte species isolated in the British Isles between 1980 and 2005 and review of worldwide dermatophyte trends over the last three decades. Med Mycol 2007;45:131-141.
Seebacher C, Brasch J, Cornely OA, Effendy I, Ginter-Hanselmayer G, Haake N, Hamm G, Hipler UC, Hof H, Korting HC, Mayser P, Giessen RM, Schlacke KH, Tietz HJ: AWMF-Leitlinie: Tinea der freien Haut. 2008.
Trombetta D, Castelli F, Sarpietro MG, Venuti V, Cristani M, Daniele C, Saija A, Mazzanti G, Bisignano G: Mechanisms of antibacterial action of three monoterpenes. Antimicrob Agents Chemother 2005;49:2474-2478.
Lo Cantore P, Iacobellis NS, De Marco A, Capasso F, Senatore F: Antibacterial activity of Coriandrum sativum L. and Foeniculum vulgare Miller var. vulgare (Miller) essential oils. J Agric Food Chem 2004;52:7862-7866.
Elgayyar M, Draughon FA, Golden DA, Mount JR: Antimicrobial activity of essential oils from plants against selected pathogenic and saprophytic microorganisms. J Food Prot 2001;64:1019-1024.
Delaquis PJ, Stanich K, Girard B, Mazza G: Antimicrobial activity of individual and mixed fractions of dill, cilantro, coriander and eucalyptus essential oils. Int J Food Microbiol 2002;74:101-109.
Singh G, Kapoor IP, Pandey SK, Singh UK, Singh RK: Studies on essential oils. 10. Antibacterial activity of volatile oils of some spices. Phytother Res 2002;16:680-682.
Kubo I, Fujita K, Kubo A, Nihei K, Ogura T: Antibacterial activity of coriander volatile compounds against Salmonella choleraesuis. J Agric Food Chem 2004;52:3329-3332.
Lixandru BE, Dracea NO, Dragomirescu CC, Dragulescu EC, Coldea IL, Anton L, Dobre E, Rovinaru C, Codita I: Antimicrobial activity of plant essential oils against bacterial and fungal species involved in food poisoning and/or food decay. Roum Arch Microbiol Immunol 2011;69:224-230.
Furletti VF, Teixeira IP, Obando-Pereda G, Mardegan RC, Sartoratto A, Figueira GM, Duarte RM, Rehder VL, Duarte MC, Hoefling JF: Action of Coriandrum sativum L. essential oil upon oral Candida albicans biofilm formation. Evid Based Complement Alternat Med 2011;2011:985832.
Silva F, Ferreira S, Duarte A, Mendonca DI, Domingues FC: Antifungal activity of Coriandrum sativum essential oil, its mode of action against Candida species and potential synergism with amphotericin B. Phytomedicine 2011;19:42-47.
Soares BV, Morais SM, Dos Santos Fontenelle RO, Queiroz VA, Vila-Nova NS, Pereira CM, Brito ES, Neto MA, Brito EH, Cavalcante CS, Castelo-Branco DS, Rocha MF: Antifungal activity, toxicity and chemical composition of the essential oil of Coriandrum sativum L. fruits. Molecules 2012;17:8439-8448.
Reichling J, Harkenthal M, Saller R: In- vitro-Untersuchungen zur antimikrobiellen Wirkung ausgewählter ätherischer Öle. Erfahrungsheilkunde 1999;6:357-366.
Kiraz N, Metintas S, Oz Y, Koc F, Koku Aksu EA, Kalyoncu C, Kasifoglu N, Cetin E, Arikan I: The prevalence of tinea pedis and tinea manuum in adults in rural areas in turkey. Int J Environ Health Res 2010;20:379-386.
Jain N, Sharma M, Saxena VN: Clinico-mycological profile of dermatophytosis in Jaipur, Rajasthan. Indian J Dermatol Venereol Leprol 2008;74:274-275.
Aghamirian MR, Ghiasian SA: Dermatophytoses in outpatients attending the Dermatology Center of Avicenna Hospital in Qazvin, Iran. Mycoses 2008;51:155-160.
Roseeuw D: Achilles foot screening project: preliminary results of patients screened by dermatologists. J Eur Acad Dermatol Venereol 1999;12(suppl 1):S6-S9; discussion S17.
Bakkali F, Averbeck S, Averbeck D, Zhiri A, Idaomar M: Cytotoxicity and gene induction by some essential oils in the yeast Saccharomyces cerevisiae. Mutat Res 2005;585:1-13.
Queiroga CL, Duarte MC, Ribeiro BB, de Magalhaes PM: Linalool production from the leaves of Bursera aloexylon and its antimicrobial activity. Fitoterapia 2007;78:327-328.
Raman A, Weir U, Bloomfield SF: Antimicrobial effects of tea-tree oil and its major components on Staphylococcus aureus, Staph. epidermidis and Propionibacterium acnes. Lett Appl Microbiol 1995;21:242-245.
Hazzit M, Baaliouamer A, Faleiro ML, Miguel MG: Composition of the essential oils of thymus and origanum species from Algeria and their antioxidant and antimicrobial activities. J Agric Food Chem 2006;54:6314-6321.
Sonboli A, Babakhani B, Mehrabian AR: Antimicrobial activity of six constituents of essential oil from Salvia. Z Naturforsch C 2006;61:160-164.
Prashar A, Hili P, Veness RG, Evans CS: Antimicrobial action of palmarosa oil (Cymbopogon martinii) on Saccharomyces cerevisiae. Phytochemistry 2003;63:569-575.
Khan A, Ahmad A, Akhtar F, Yousuf S, Xess I, Khan LA, Manzoor N: Ocimum sanctum essential oil and its active principles exert their antifungal activity by disrupting ergosterol biosynthesis and membrane integrity. Res Microbiol 2010;161:816-823.
Parveen M, Hasan MK, Takahashi J, Murata Y, Kitagawa E, Kodama O, Iwahashi H: Response of Saccharomyces cerevisiae to a monoterpene: evaluation of antifungal potential by DNA microarray analysis. J Antimicrob Chemother 2004;54:46-55.
Suhonen R, Keskinen H, Bjorksten F, Vaheri E, Zitting A: Allergy to coriander. A case report. Allergy 1979;34:327-330.
Sinha SM, Pasricha JS, Sharma R, Kandhari KC: Vegetables responsible for contact dermatitis of the hands. Arch Dermatol 1977;113:776-779.
van den Akker TW, Roesyanto-Mahadi ID, van Toorenenbergen AW, van Joost T: Contact allergy to spices. Contact Dermatitis 1990;22:267-272.
Niinimäki A: Spices; in Kanerva L, Elsner P, Wahlberg JE, Maibach HI: Handbook of Occupational Dermatology. Berlin, Springer, 2000, pp 767-770.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.