Background: Condylomata acuminata (CA) are caused by human papillomavirus. Most conventional therapies for CA have high recurrence rate. Objectives: To compare the recurrence rate of 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) combined with CO2 laser and CO2 laser alone for CA treatment in mainland China. Methods: In this meta-analysis, 2,048 cases of CA from 22 articles were divided into two groups. The treatment group was treated by using ALA-PDT combined with CO2 laser, and CO2 laser alone was applied in the control group. The recurrence rate of the two groups was calculated and compared. Results: The recurrence rate was 42.67% (451/1,057) in the control group and 10.29% (102/991) in the treatment group, with a significant statistical difference between the two groups (χ2 = 271.98, p < 0.0001). Conclusion: ALA-PDT combined with CO2 laser was more effective in decreasing the recurrence rate of CA compared with CO2 laser alone. It might offer a wide clinical application for CA treatment.

Keywords:
Photodynamic therapy, CO2 laser, Condylomata acuminata, Recurrence
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