Background: In childhood psoriasis, physicians aim for an effective and safe treatment such as with dithranol. This study presents the largest study of dithranol-treated patients described in the literature. Objective: The aim of the study was to determine the position of dithranol in the treatment strategy for psoriasis. Methods: All juvenile patients receiving dithranol treatment at our center were evaluated retrospectively. Results: Sixty patients (with 82 treatment episodes in total) were included. The mean age at the start of dithranol treatment was 11.1 years (range: 3.7–17.9 years). The result of the treatment was: excellent (3.7%), good (69.5%), moderate (8.5%), reasonable (13.4%) or disappointing (4.9%). Mild irritation was seen in 39%, and severe irritation in 63% of the patients. Conclusions: Dithranol can be regarded as an efficacious and safe topical therapy for the treatment of childhood psoriasis. It is a valuable alternative topical treatment which should not be disregarded in the treatment regimen for childhood psoriasis and should be commenced before ultraviolet or systemic treatments are initiated.

1.
Galewski E: Über Cignolin, ein Ersatzpräparat des Chrysarobins. Dermatol Wochenschr 1916;6:113–115.
2.
Ashton RE, André P, Lowe NJ, Whitefield M: Anthralin: historical and current perspectives. J Am Acad Dermatol 1983;9:173–192.
3.
van de Kerkhof PC, Barker J, Griffiths CE, Kragballe K, Mason J, Menter A, Papp K: Psoriasis: consensus on topical therapies. J Eur Acad Dermatol Venereol 2008;22:859–870.
4.
Zvulunov A, Anisfeld A, Metzker A: Efficacy of short-contact therapy with dithranol in childhood psoriasis. Int J Dermatol 1994;33:808–810.
5.
Guerrier CJ, Porter DI: An open assessment of 0.1% dithranol in a 17% urea base (‘Psoradrate’ 0.1%) in the treatment of psoriasis of children. Curr Med Res Opin 1983;8:446–450.
6.
Christensen OB, Holst R, Hradil E, Brolund L: Clinical response and side effects in the treatment of psoriasis with UV-B and -A novel dithranol formulation. Acta Derm Venereol Suppl (Stockh) 1989;146:96–100.
7.
Duschet P, Schwarz T, Pusch M, Wagner A, Gschnait F: Anthralin minute entire skin treatment: a follow-up and comparison with methoxsalen plus ultraviolet light. Arch Dermatol 1987;123:428–429.
8.
Schwarz T, Gschnait F: Anthralin minute entire skin treatment: a new outpatient therapy for psoriasis. Arch Dermatol 1985;121:1512–1515.
9.
van de Kerkhof PC: Dithranol treatment in psoriasis: after 75 years, still going strong. Eur J Dermatol 1991;1:79–88.
10.
de Jager ME, de Jong EM, van de Kerkhof PC, Seyger MM: Efficacy and safety of treatments for childhood psoriasis: a systematic literature review. J Am Acad Dermatol 2009, E-pub ahead of print.
11.
Menter A, Korman NJ, Elmets CA, Feldman SR, Gelfand JM, Gordon KB, Gottlieb A, Koo JY, Lebwohl M, Lim HW, van Voorhees AS, Beutner KR, Bhushan R: Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy. J Am Acad Dermatol 2010;62:114–135.
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