Juvenile xanthogranuloma in adulthood is an infrequent non-Langerhans cell histiocytosis, which may simulate malignant tumors such as basal cell carcinoma (BCC) or amelanotic melanoma. Dermoscopy has been described as a useful tool in the preoperative diagnosis of xanthogranuloma. We report a xanthogranuloma on the suprapubic area of a 48-year-old female, which clinically and dermoscopically mimicked a BCC with a yellowish hue and arborizing vessels. Reflectance confocal microscopy exhibited large highly refractive atypical cells in the dermis, some of them with pleomorphic nuclei, corresponding to Touton cells in the histopathological study. To our knowledge this is the first description of the clinical, dermoscopic and confocal microscopy correlations of a xanthogranuloma.

Rodriguez J, Ackerman B: Xanthogranuloma in adults. Arch Dermatol 1976;112:43–44.
Torok E, Daroczy J: Juvenile xanthogranuloma: an analysis of 45 cases by clinical follow-up, light and electron microscopy. Acta Derm Venereol 1985;65:167–171.
Chang SE, Cho S, Choi JC, et al: Clinicohistopathologic comparison of adult type and juvenile type xanthogranulomas in Korea. J Dermatol 2001;28:413–418.
Cohen BA, Hood A: Xanthogranuloma: report on clinical and histological findings in 64 patients. Pediatr Dermatol 1989;6:262–266.
Hernandez-Martin A, Baselga E, Drolet BA, Esterly NB: Juvenile xanthogranuloma. J Am Acad Dermatol 1997;36:355–367.
Palmer A, Bowling J: Dermoscopic appearance of juvenile xanthogranuloma. Dermatology 2007;215:256–259.
Rubegni P, Mandato F, Fimiani M: Juvenile xanthogranuloma: dermoscopic pattern. Dermatology 2009;218:380.
Cavicchini S, Tourlaki A, Tanci C, Alessi E: Dermoscopy of solitary yellow lesions in adults. Ach Dermatol 2008;144:1412.
Argenziano G, Sover HP, Gill M, et al: Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet. J Am Acad Dermatol 2003;48:679–693.
Menzies SW: Dermoscopy of pigmented basal cell carcinoma. Clin Dermatol 2002;20:268–269.
Segura S, Puig S, Carrera C, Palou J, Malvehy J: Development of a two-step method for the diagnosis of melanoma by reflectance confocal microscopy. J Am Acad Dermatol 2009; 61: 216–229.
Agero AL, Busan KJ, Benvenuto-Andrade C, et al: Reflectance confocal microscopy of pigmented basal cell carcinoma. J Am Acad Dermatol 2006;54:638–643.
Gonzalez S, Tannous Z: Real-time in vivo confocal reflectance microscopy of basal cell carcinoma. J Am Acad Dermatol 2002;47:869–874.
Argenziano G, Zalaudek I, Corona R, et al: Vascular structures in skin tumors: a dermoscopy study. Arch Dermatol 2004;140:1485–1489.
Pellacani G, Cesinaro AM, Seidenari S: Reflectance-mode confocal microscopy of pigmented skin lesions – improvement in melanoma diagnostic specificity. J Am Acad Dermatol 2005;53:979–985.
Langley RG, Walsh N, Sutherland AE, et al: The diagnostic accuracy of in vivo confocal scanning microscopy compared to dermoscopy of benign and malignant melanocytic lesions: a prospective study. Dermatology 2007;215:365–372.
Scope A, Ardigo M, Marghoob AA: Correlation of dermoscopic globule-like structures of dermatofibroma using reflectance confocal microscopy. Dermatology 2008;216:81–82.
Ardigo M, Zieff J, Scope A, et al: Dermoscopic and reflectance confocal microscope findings of trichoepithelioma. Dermatology 2007;215:354–358.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.