Background: A number of otherwise healthy women with or without clinical alopecia complain of recurrent hair loss, presumably reflecting seasonality in the growth and shedding of hair. Objective: To test the hypothesis that periodicity in hair shedding reflects seasonal changes in human hair growth. Methods: Retrospective case study over a period of 6 years of apparently healthy women with the complaint of hair loss. All underwent biochemical investigations, and trichograms were made. Results: After exclusion of patients with a disease or on drugs known to cause hair loss, 823 women remained. Analysis of trichograms demonstrated annual periodicity in the growth and shedding of hair, manifested by a maximal proportion of telogen hairs in summer. A second peak seems to exist, though it is less pronounced, in spring. The telogen rates were lowest in late winter. Conclusions: These results confirm the findings of former authors who have indicated seasonal changes in human hair growth, though this is the first study performed systematically in a representative number of women.

1.
Sinclair R: Diffuse hair loss. Int J Dermatol 1999;38(suppl 1):8–18.
2.
De Villez RL, Jacobs JP, Szpunar CA, Warner ML: Androgenetic alopecia in the female: treatment with 2% topical minoxidil solution. Arch Dermatol 1994;3:303–307.
3.
Lucky AW, Piacquadio DJ, Ditre CM, et al: A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss. J Am Acad Dermatol 2004;50:541–553.
4.
Price VH, Menefee E: Quantitative estimation of hair growth. I. Androgenetic alopecia in women: effect of minoxidil. J Invest Dermatol 1990;95:683–687.
5.
Sinclair R, Wewerinke M, Jolley C: Treatment of female pattern hair loss with oral antiandrogens. Br J Dermatol 2005;152:466–473.
6.
Hoedemaker C, van Egmond S, Sinclair R: Treatment of female pattern hair loss with a combination of spironolactone and minoxidil. Australas J Dermatol 2007;48:43–45.
7.
Iorizzo M, Vincenzi C, Voudouris S, Piraccini BM, Tosti A: Finasteride treatment of female pattern hair loss. Arch Dermatol 2006;142:298–302.
8.
Price VH, Roberts JL, Hordinsky M, et al: Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia. J Am Acad Dermatol 2000;43:768–776.
9.
Whiting DA, Waldstreicher J, Sanchez M, Kaufman KD: Measuring reversal of hair miniaturization in androgenetic alopecia by follicular counts in horizontal sections of serial scalp biopsies: results of finasteride 1 mg treatment of men and postmenopausal women. J Invest Dermatol Symp Proc 1999;4: 282–284.
10.
Vexiau P, Chaspoux C, Boudou P, et al: Effects of minoxidil 2% vs cyproterone acetate treatment on female androgenetic alopecia: a controlled, 12-month randomized trial. Br J Dermatol 2002;146:992–999.
11.
Rushton DH: Investigating and managing hair loss in apparently healthy women. Can J Dermatol 1993;5:455–461.
12.
Paus R, Cotsarelis G: The biology of hair follicles. N Engl J Med 1999;341:491–497.
13.
Piérard-Franchimont C, Piérard GE: Teloptosis, a turning point in hair shedding biorhythms. Dermatology 2001;203:115–117.
14.
Paus R: Control of the hair cycle and hair diseases as cycling disorders. Curr Opin Dermatol 1996;3:248–258.
15.
Kligman AM: Pathologic dynamics of human hair loss. I. Telogen effluvium. Arch Dermatol 1961;83:175–198.
16.
Headington JT: Telogen effluvium: new concepts and review. Arch Dermatol 1993;129:356–363.
17.
Braun-Falco O, Heilgemeier CP: The trichogram: structural and functional basis, performance, and interpretation. Sem Dermatol 1985;4:40–52.
18.
Blume-Peytavi U, Orfanos CE: Microscopy of the hair – the trichogram; in Drup J, Jemec GBE (eds): Handbook of Non-Invasive Methods and the Skin. London, CRC Press, 1995, pp 549–554.
19.
Orentreich N: Scalp replacement in man; in Montagna W, Bobson RL (eds): Advances in Biology of Skin. Oxford, Pergamon, 1969, vol IX: Hair Growth, pp 99–108.
20.
Randall VA, Ebling FJG: Seasonal changes in human hair growth. Br J Dermatol 1991;124:146–151.
21.
Courtois M, Loussouarn G, Hourseau S, Grollier JF: Periodicity in the growth and shedding of hair. Br J Dermatol 1996;134:47–54.
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