Background: Few data suggest oat-based cosmetics may cause allergic reactions in atopic subjects, especially when sensitized to cereals. Objectives: To evaluate the risk of immediate and delayed allergic reactions to repeated and maximized applications (RMA) of oat-containing cosmetics and oat extracts and their tolerance in cereal-sensitized atopic adults. Methods: Open-label pilot study in 12 cereal-sensitized atopic adults over 45 days. Open tests and RMA were performed with Rhealba® oat-containing cosmetics at day 0 (D0) and D10, and from D10 to D31. Patch and prick tests were performed at D7 and D42 with wheat and Rhealba oat extracts and the study cream. Results: The RMA of oat-based cosmetics in cereal-sensitized atopic adults did not induce any immediate or delayed allergic reaction and was well tolerated. No immediate or delayed positive skin test to oat extracts was observed. Conclusion: Sensitization to cereals does not increase the risk of allergic reactions to oat-containing cosmetics.

Keywords:
Atopic dermatitis, Tolerance, local and systemic, Oats
1.
Murphy GM: Skin diseases with high public health impact: melanoma. Eur J Dermatol 2007;17:559–562.
2.
Loden M: The skin barrier and use of moisturizers in atopic dermatitis. Clin Dermatol 2003;21:145–157.
3.
Imokawa G: Lipid abnormalities in atopic dermatitis. J Am Acad Dermatol 2001;45:S29–S32.
4.
Berard F, Marty JP, Nicolas JF: Allergen penetration through the skin. Eur J Dermatol 2003;13:324–330.
5.
Loden M: Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol 2003;4:771–788.
6.
Darsow U, Lubbe J, Taieb A, Seidenari S, Wollenberg A, Calza AM, Giusti F, Ring J, European Task Force on Atopic Dermatitis. Position paper on diagnosis and treatment of atopic dermatitis. J Eur Acad Dermatol Venereol 2005;19:286–295.
7.
Aries MF, Vaissiere C, Pinelli E, Pipy B, Charveron M: Avena Rhealba® inhibits A23187-stimulated arachidonic acid mobilization, eicosanoid release, and cPLA2 expression in human keratinocytes: potential in cutaneous inflammatory disorders. Biol Pharm Bull 2005;28:601–606.
8.
Grimalt R, Mengeaud V, Cambazard F, Study Investigators’ Group: The steroid-sparing effect of an emollient therapy in infants with atopic dermatitis: a randomized controlled study. Dermatology 2007;214:61–67.
9.
Pazzaglia M, Jorizzo M, Parente G, Tosti A: Allergic contact dermatitis due to avena extract. Contact Dermatitis 2000;42:364.
10.
Dempster JG: Contact dermatitis from bran and oats. Contact Dermatitis 1981;7:122.
11.
Riboldi A, Pigatto PD, Altomare GF, Gibelli E: Contact allergic dermatitis from oatmeal. Contact Dermatitis 1988;18:316–317.
12.
De Paz Arranz S, Pérez Montero A, Remón LZ, Molero MI: Allergic contact urticaria to oatmeal. Allergy 2002;57:1215.
13.
Boussault P, Léauté-Labrèze C, Saubusse E, Maurice-Tison S, Perromat M, Roul S, Sarrat A, Taïeb A, Boralevi F: Oat sensitization in children with atopic dermatitis: prevalence, risks and associated factors. Allergy 2007;62:1251–1256.
14.
Williams HC, Burney PG, Strachan D, Hay RJ: The UK Working Party’s Diagnostic Criteria for Atopic Dermatitis. II. Observer variation of clinical diagnosis and signs of atopic dermatitis. Br J Dermatol 1994;131:397–405.
15.
Taïeb A: When and how to perform allergy tests in children and adults with atopic dermatitis. Eur J Dermatol 2007;17:263–266.
16.
Fischer T, Adams RM: Diagnostic patch testing; in Adams RM (ed): Occupational Skin Diseases. New York, Grüne and Stratton, 1990, pp 223–253.
17.
Skin tests used in type I allergy testing. Position paper. Sub-Committee on Skin Tests of the European Academy of Allergology and Clinical Immunology. Allergy1989;44:1–59.
18.
Pigatto P, Bigardi A, Caputo R, Angelini G, Foti C, Grandolfo M, Rizer RL: An evaluation of the allergic contact dermatitis potential of colloidal grain suspensions. Am J Contact Dermat 1997;8:207–209.
19.
Brasch J, Schnuch A, Uter W: Patch-test reaction patterns in patients with a predisposition to atopic dermatitis. Contact Dermatitis 2003;49:197–201.
20.
Klas PA, Corey G, Storrs FJ, Chan SC, Hanifin JM: Allergic and patch test reactions and atopic disease. Contact Dermatitis 1996;34:121–124.
21.
Fabijanski S, Altosaar I, Lauriere M, Pernollet JC, Mosse J: Antigenic homologies between oat and wheat globulins. FEBS Lett 1985;182:475–478.
22.
Varjonen E, Vainio E, Kalimo K, Juntunen-Backman K, Savolainen J: Skin-prick test and RAST responses to cereals in children with atopic dermatitis: characterization of IgE-binding components in wheat and oats by an immunoblotting method. Clin Exp Allergy 1995;25:1100–1107.
23.
Damodaran S: Protein-stabilized foams and emulsions; in Damodaran S, Paraf A (eds): Food Proteins and Their Applications. New York, Marcel Dekker, 1997, pp 56–127.
24.
Popineau Y, Huchet B, Larre C, Berot S: Foaming and emulsifying properties of fractions of gluten peptides obtained by limited enzymatic hydrolysis and ultrafiltration. J Cereal Sci 2002;35:327–335.
25.
Sanchez-Perez J, Sanz T, Garcia-Diez A: Allergic contact dermatitis from hydrolyzed wheat protein in cosmetic cream. Contact Dermatitis 2000;42:360.
26.
Hann S, Hughes M, Stone N: Allergic contact dermatitis to hydrolyzed wheat protein in a cosmetic cream. Contact Dermatitis 2007;56:119–120.
27.
Varjonen E, Petman L, Makinen-Kiljunen S: Immediate contact allergy from hydrolyzed wheat in a cosmetic cream. Allergy 2000;55:294–296.
28.
Pecquet C, Lauriere M, Huet S, Leynadier F: Is the application of cosmetics containing protein-derived products safe? Contact Dermatitis 2002;46:123.
29.
Laurière M, Pecquet C, Bouchez-Mahiout I, Snégaroff J, Bayrou O, Raison-Peyron N, Vigan M: Hydrolysed wheat proteins present in cosmetics can induce immediate hypersensitivities. Contact Dermatitis 2006;54:283–289.
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2009
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