Background: In analogy to acne, oral isotretinoin has been considered in the treatment of hidradenitis suppurativa (HS). Objectives: To assess the efficacy of oral isotretinoin according to patients. Methods: From 1999 to 2006, 358 consecutive HS patients were interviewed and examined. A standardized record of the data was performed for each patient during the first consultation. Patients were questioned regarding the effect of previous treatment with oral isotretinoin: patients had to grade the effect as either ‘improved’, ‘no effect’ or ‘worse’. Results: Fourteen patients (16.1%) declared an improvement, 67 patients (77%) no effect and 6 patients (6.9%) worsening of HS. Conclusion: According to our patients, oral isotretinoin is not effective in the treatment of HS.

1.
Sellheyer K, Krahl D: Hidradenitis suppurativa is acne inversa. An appeal to finally abandon a misnomer. Int J Dermatol 2005;44:535–540.
2.
Poli F, Jemec GB, Revuz J: Clinical presentation; in Jemec GBE, Revuz J, Leyden J (eds): Hidradenitis Suppurativa. Heidelberg, Springer, 2006, pp 11–24.
3.
Chivot M: Acne flare-up and deterioration with oral isotretinoin (in French). Ann Dermatol Venereol 2001;128:224–228.
4.
Lehucher Ceyrac D, Chaspoux C, Sulimovic L, Morel P, Lefrancq H: Aggravation of acne by isotretinoin. 6 cases, predictive factors (in French). Ann Dermatol Venereol 1998;125:496–499.
5.
Boer J: Oral retinoids for hidradenitis suppurativa; in Jemec GBE, Revuz J, Leyden J (eds): Hidradenitis Suppurativa. Heidelberg, Springer, 2006, pp 128–134.
6.
Boer J, van Gemert MJ: Long-term results of isotretinoin in the treatment of 68 patients with hidradenitis suppurativa. J Am Acad Dermatol 1999;40:73–76.
7.
Dicken CH, Powell ST, Spear KL: Evaluation of isotretinoin treatment of hidradenitis suppurativa. J Am Acad Dermatol 1984;11:500–502.
8.
Geiger JM: Retinoids and sebaceous gland activity. Dermatology 1995;191:305–310.
9.
Lupi-Pégurier L, Muller-Bolla M, Fontas E, Ortonne JP: Reduced salivary flow induced by systemic isotretinoin may lead to dental decay. A prospective clinical study. Dermatology 2007;214:221–226.
10.
Jemec GB, Gniadecka M: Sebum excretion in hidradenitis suppurativa. Dermatology 1997;194:325–328.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.