Background: Treatment of multiple cutaneous piloleiomyomas which are rare, frequently painful, benign tumors originating from the arrector pilorum muscle of hair follicles is difficult. Objective: To determine the efficiency of botulinum toxin type A (BT-A) treatment for pain relief of cutaneous piloleiomyomas. Methods: A patient with multiple painful piloleiomyomas was treated with local injections of 200 units of BT-A. Results: There was a rapid and sustained decrease in pain. Treatment was repeated every 3 months for 2 years with the same efficacy. Conclusion: BT-A may be a promising new treatment option for multiple painful cutaneous piloleiomyomas.

Calonje E, MacKie RM: Soft-tissue tumours and tumour-like conditions; in Burns T, Breathnach S, Cox N, Griffith C (eds): Rook’s Textbook of Dermatology, ed 7. Oxford, Blackwell Science, 2004, vol 3, pp 53.40–53.42.
Montgomery H, Winkelman RK: Smooth muscle tumors of the skin. Arch Dermatol 1959;79:32–41.
Raj S, Calonje E, Kraus M, Kavanagh G, Newman PL, Fletcher CD: Cutaneous pilar leiomyoma: clinicopathologic analysis of 53 lesions in 45 patients. Am J Dermatopathol 1997;19:2–9.
Garcia Muret MP, Pujol RM, Alomar A, Calaf J, de Moragas JM: Familial leiomyomatosis cutis et uteri (Reed’s syndrome). Arch Dermatol Res 1988;280(suppl):S29–S32.
Martinez-Mir A, Gordon D, Horev L, Klapholz L, Ott J, Christiano AM, Zlotogorski A: Multiple cutaneous and uterine leiomyomas: refinement of the genetic locus for multiple cutaneous and uterine leiomyomas on chromosome 1q 42.3–43. J Invest Dermatol 2002;118:876–880.
Archer CB, Greaves MW: Assessment of treatment for painful cutaneous leiomyomas. J Am Acad Dermatol 1987;17:141–142.
Alam M, Rabinowitz AD, Engler DE: Gabapentin treatment of multiple piloleiomyoma-related pain. J Am Acad Dermatol 2002;46:S27–S29.
Mann PR: Leiomyoma cutis: an electron microscope study. Br J Dermatol 1970;82:463–469.
Cherington M: Clinical spectrum of botulism. Muscle Nerve 1998;21:701–710.
Münchau A, Bhatia KP: Uses of botulinum toxin injection in medicine today. BMJ 2000;320:161–165.
Ji J, Lau H, Sheu L, Diamant NE, Gaisano HY: Distinct regional expression of SNARE proteins in the feline oesophagus. Neurogastroenterol Motil 2002;14:383–394.
Vaidyanathan VV, Yoshino K, Jahnz M, Dorries C, Bade S, Nauenburg S, Niemann H, Binz T: Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage. J Neurochem 1999;72:327–337.
Arezzo JC: Possible mechanisms for the effects of botulinum toxin on pain. Clin J Pain 2002;18(suppl):S125–S132.
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