Background: Hidradenitis suppurativa (Verneuil’s disease) is a chronic suppurative dermatosis involving apocrine glands with a severe impact on the quality of life, which is enhanced by the fact that the drugs usually prescribed are poorly effective. Objective: We discuss a new therapeutic approach based on zinc salts. Methods: We performed a pilot study on 22 patients, mainly from grade I or II in Hurley’s classification. All included patients had previously been prescribed a treatment (antibiotic, isotretinoin, surgery or anti-androgens), which was inefficient. They were then treated with 90 mg of zinc gluconate per day (15 mg zinc per Rubozinc® capsule). Results: We observed a clinical response in all patients, with 8 complete remissions (CR) and 14 partial remissions (PR). When CR was obtained, the treatment was progressively decreased (average of 3.5 capsules/day); 4/22 patients experienced side-effects, mainly gastro-intestinal. Conclusion: Zinc salts could provide a new therapeutic alternative for the treatment of hidradenitis suppurativa.

Jemec GB, Heidenheim M, Nielsen NH: The prevalence of hidradenitis suppurativa and its potential precursor lesions. J Am Acad Dermatol 1996;35:191–194.
Sartorius K, Lapins J, Jalal S, Emtestam L, Hedberg M: Bacteraemia in patients with hidradenitis suppurativa undergoing carbon dioxide laser surgery: detection and quantification of bacteria by lysis-filtration. Dermatology 2006;213:305–312.
Yu CC, Cook MG: Hidradenitis suppurativa: a disease of follicular epithelium, rather than apocrine glands. Br J Dermatol 1990;122:763–769.
Brocard A: Maladie de Verneuil et zinc: une nouvelle approche thérapeutique; thèse médecine, Service de dermatologie, CHU Nantes, avril 2005.
Dreno B, Amblard P, Agache P, Sirot S, Litoux P: Low doses of zinc gluconate for inflammatory acne. Acta Derm Venereol (Stockh) 1989;69:541–543.
Dreno B, Moyse D, Alirezai M, Amblard P, Auffret N, Beylot C, Bodokh I, Chivot M, Daniel F, Humbert P, Meynadier J, Poli F, and private practice dermatologists coordinated by the Acne Research and Study Group (GREA): Multicenter randomised comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris. Dermatology 2001;203:135–140.
Dreno B, Trossaert M, Boiteau HL, Litoux P: Zinc salts effects on granulocyte zinc concentration and chemotaxis in acne patients. Acta Derm Venereol 1992;72:250–252.
Chvapil M, Stankova L, Zukoski C IV, Zukoski C III: Inhibition of some functions of polymorphonuclear leukocytes by in vitro zinc. J Lab Clin Med 1977;89:135–146.
Gueniche A, Viac J, Lizard G, Charveron M, Schmitt D, et al: Protective effect of zinc on keratinocyte activation markers induced by interferon or nickel. Acta Derm Venereol 1995;75:19–23.
Sainte Marie I, Jumbou O, Tenaud I, Dréno B: Comparative study of the in vitro inflammatory activity of three nickels salts on keratinocytes. Acta Derm Venereol 1998;78:169–172.
Sugimoto Y, Lopez-Solachez I, Labrie F, Luu-The V: Cations inhibit specifically type I 5α-reductase found in human skin. J Invest Dermatol 1995;104:775–778.
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