Background: Few large-scale epidemiological studies have been performed on the prevalence of itch. Itch and pain are common and complex symptoms which contribute to the burden of disease. Although there is antagonistic interaction between itch and pain, there are also many similarities in their pathophysiology. Objective: To investigate possible associations between chronic itch and chronic pain in a large population. Methods: The design was cross-sectional. 18,770 adults completed a self-administered questionnaire addressing sociodemographic factors, psychosocial factors and self-reported health including chronic itch and chronic pain. Results: Individuals reporting pain and itch were more likely to be women (80 and 60%, respectively, compared to 55% in the total sample), had a lower income (49 and 37% compared to 32%), were more likely to be depressed (36 and 20% compared to 11%) and reported poorer well-being (74 and 34% compared to 25%). In an adjusted logistic regression, chronic pain was strongly associated with chronic itch (OR = 1.79, 95% CI = 1.43–2.24). Conclusion: This study demonstrates the association of chronic itch and chronic pain and points out the need of further studies that focus on both symptoms in dermatological diseases.

Atanassoff PG, Brull SJ, Zhang J, Greenquist K, Silverman DG, Lamotte RH: Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. Somatosens Mot Res 1999;16:291– 298.
Schmelz M: Itch and pain. Dermatol Ther 2005;18:304–307.
Dalgard F, Svensson A, Holm JO, Sundby J: Self-reported skin morbidity among adults: associations with quality of life and general health in a Norwegian survey. J Invest Dermatol Symp Proc 2004;9:120–125.
Brekke M, Hjortdahl P, Kvien TK: Severity of musculoskeletal pain: relations to socioeconomic inequality. Soc Sci Med 2002;54:221–228.
Brekke M, Hjortdahl P, Thelle DS, Kvien TK: Disease activity and severity in patients with rheumatoid arthritis: relations to socioeconomic inequality. Soc Sci Med 1999;48:1743–1750.
Rustoen T, Wahl AK, Hanestad BR, Lerdal A, Paul S, Miaskowski C: Age and the experience of chronic pain: differences in health and quality of life among younger, middle-aged, and older adults. Clin J Pain 2005;21:513–523.
Lame IE, Peters ML, Vlaeyen JW, Kleef M, Patijn J: Quality of life in chronic pain is more associated with beliefs about pain, than with pain intensity. Eur J Pain 2005;9:15–24.
Kerr S, Fairbrother G, Crawford M, Hogg M, Fairbrother D, Khor KE: Patient characteristics and quality of life among a sample of Australian chronic pain clinic attendees. Intern Med J 2004;34:403–409.
Fishbain DA, Cutler R, Rosomoff HL, Rosomoff RS: Chronic pain-associated depression: antecedent or consequence of chronic pain? A review. Clin J Pain 1997;13:116–137.
Blackburn-Munro G, Blackburn-Munro RE: Chronic pain, chronic stress and depression: coincidence or consequence? J Neuroendocrinol 2001;13:1009–1023.
Dalgard F, Svensson A, Sundby J, Dalgard OS: Self-reported skin morbidity and mental health: a population survey among adults in a Norwegian city. Br J Dermatol 2005;153:145–149.
Bhopal R: Revisiting race/ethnicity as a variable in health research. Am J Public Health 2002;92:156–157.
Bhopal R, Donaldson L: White, European, Western, Caucasian, or what? Inappropriate labeling in research on race, ethnicity, and health. Am J Public Health 1998;88:1303–1307.
Derogatis LR, Lipman RS, Rickels K, Uhlenhuth EH, Covi L: The Hopkins Symptom Checklist (HSCL): a self-report symptom inventory. Behav Sci 1974;19:1–15.
Strand BH, Dalgard OS, Tambs K, Rognerud M: Measuring the mental health status of the Norwegian population: a comparison of the instruments SCL-25, SCL-10, SCL-5 and MHI-5 (SF-36). Nord J Psychiatry 2003;57:113–118.
Altman DG: Practical Statistics for Medical Research. London, Chapman & Hall, 1991.
Dalgard F, Svensson A, Holm JO, Sundby J: Self-reported skin complaints: validation of a questionnaire for population surveys. Br J Dermatol 2003;149:794–800.
Wahlgren CF: Measurement of itch. Semin Dermatol 1995;14:277–284.
Marmot MG, Smith GD, Stansfeld S, et al: Health inequalities among British civil servants: the Whitehall II study. Lancet 1991;337:1387–1393.
Bhopal R, Hayes L, White M, et al: Ethnic and socio-economic inequalities in coronary heart disease, diabetes and risk factors in Europeans and South Asians. J Public Health Med 2002;24:95–105.
Yosipovitch G, Greaves MW, Schmelz M: Itch. Lancet 2003;361:690–694.
Sogaard AJ, Selmer R, Bjertness E, Thelle D: The Oslo Health Study: the impact of self-selection in a large, population-based survey. Int J Equity Health 2004;3:3.
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