Background: Atopic dermatitis (AD) is aggravated by mechanical irritation and bacterial colonization. Objective: This study compared the efficacy of an antimicrobial silk fabric (DermaSilk®) with that of a topical corticosteroid in the treatment of AD. Methods: Fifteen children were enrolled and wore a dress, where the left side was made of DermaSilk and the right side was made of cotton. The right arm and leg were treated daily with the corticosteroid mometasone for 7 days. The treatment efficacy was measured with a modified EASI (Eczema Area and Severity Index) and with an assessment by the patients/parents and by a physician. All patients were evaluated at baseline, as well as 7 and 21 days after the initial examination. Results: All parameters showed that, irrespective of the treatment, there was a significant decrease of eczema after 7 days. No significant difference between DermaSilk-treated and corticosteroid-treated skin could be observed. Conclusion: DermaSilk showed potential to become an effective treatment of AD.

Wüthrich B: Clinical aspects, epidemiology, and prognosis of atopic dermatitis. Ann Allergy Asthma Immunol 1999;83:464–470.
Aly R, Maibach HI, Shinefield HR: Microbial flora of atopic dermatitis. Arch Dermatol 1977;113:780–782.
Goodyear HM, Watson PJ, Egan SA, Price EH, Kenny PA, Harper JI: Skin microflora of atopic eczema in first time hospital attenders. Clin Exp Dermatol 1993;18:300–304.
Stalder JF, Fleury M, Sourisse M, Allavoine T, Chalamet C, Brosset P, Litoux P: Comparative effects of two topical antiseptics (chlorhexidine vs. KMn04) on bacterial skin flora in atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 1992;176:132–134.
Ricci G, Patrizi A, Mandrioli P, Specchia F, Medri M, Menna G, Masi M: Evaluation of the antibacterial activity of a special silk textile in the treatment of atopic dermatitis. Dermatology 2006;213:224–227.
Roll A, Cozzio A, Fischer B, Schmid-Grendelmeier P: Microbial colonization and atopic dermatitis. Curr Opin Allergy Clin Immunol 2004;4:373–378.
Leung DY, Bieber T: Atopic dermatitis. Lancet 2003;361:151–160.
Lever R, Hadley K, Downey D, Mackie R: Staphylococcal colonization in atopic dermatitis and the effect of topical mupirocin therapy. Br J Dermatol 1988;119:189–198.
Leyden JJ, Marples RR, Kligman AM: Staphylococcus aureus in the lesions of atopic dermatitis. Br J Dermatol 1974;90:525–530.
Pournaras CC, Lübbe J, Saurat J-H: Staphylococcal colonization in atopic dermatitis treatment with topical tacrolimus (Fk506). J Invest Dermatol 2001;116:480–481.
Stalder JF, Fleury M, Sourisse M, Rostin M, Pheline F, Litoux P: Local steroid therapy and bacterial skin flora in atopic dermatitis. Br J Dermatol 1994;131:536–540.
Bendsoe N, Bjornberg A, Asnes H: Itching from wool fibres in atopic dermatitis. Contact Dermatitis 1987;17:21–22.
Hambly EM, Levia L, Wilkinson DS: Wool intolerance in atopic subjects. Contact Dermatitis 1978;4:240–241.
Hatch KL, Maibach HI: Textile fiber dermatitis. Contact Dermatitis 1985;12:1–11.
Diepgen TL, Stabler A, Hornstein OP: Textile intolerance in atopic eczema – a controlled clinical study. Z Hautkr 1990;65:907–910.
Hermanns JF, Goffin V, Arrese JE, Rodriguez C, Pierard GE: Beneficial effects of softened fabrics on atopic skin. Dermatology 2001;202:167–170.
Gettings RL, Triplett BL: A new durable antimicrobial finish for textiles. AATCC Book of Papers, 1978, pp 259–261.
Ricci G, Patrizi A, Bendandi B, Menna G, Varotti E, Masi M: Clinical effectiveness of a silk fabric in the treatment of atopic dermatitis. Br J Dermatol 2004;150:127–131.
Hanifin J, Raijka G: Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 1980;92:44–47.
Gauger A, Mempel M, Schekatz A, Schäfer T, Ring J, Abeck D: Silver-coated textiles reduce Staphylococcus aureus colonization in patients with atopic eczema. Dermatology 2003;207:15–21.
Waldram JB: The efficacy of traditional medicine: current theoretical and methodological issues. Med Anthropol Q 2000;14:603–625.
Prakash A, Benfield P: Topical mometasone. A review of its pharmacological properties and therapeutic use in the treatment of dermatological disorders. Drugs 1998;55:145–163.
Schnopp C, Holtmann C, Stock S, Remling R, Fölster-Holst R, Ring J, Abeck D: Topical steroids under wet-wrap dressings in atopic dermatitis – a vehicle-controlled trial. Dermatology 2002;204:56–59.
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