Background: The relation between human papillomavirus (HPV) and extragenital Bowen’s disease (BD) is controversial. Methods: This study used in situ hybridisation to evaluate the rate of HPV in extragenital cutaneous BD and investigated possible relations with immune status and exposure of skin to light. Results: HPV DNA was detected in 58% of 69 samples from 50 patients. The percentage of HPV detection was not significantly higher in exposed (55%) than unexposed areas (65%), and no difference in HPV rate was found between immunosuppressed and immunocompetent patients. Conclusion: Thus, this study confirms the high rate of HPV detection in extragenital cutaneous BD and suggests that there is no apparent relation concerning exposed areas and immune status.

1.
Harwood CA, Proby CM: Human papillomaviruses and non-melanoma skin cancer. Curr Opin Infect Dis 2002;15:101–114.
2.
Berkhout RJ, Bouwes Bavinck JN, ter Schegget J: Persistence of human papillomavirus DNA in benign and (pre)malignant skin lesions from renal transplant recipients. J Clin Microbiol 2000;38:2087–2096.
3.
Harwood CA, Surentheran T, McGregor JM, Spink PJ, Leigh IM, Breuer J, Proby CM: Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals. J Med Virol 2000;61:289–297.
4.
Biliris KA, Koumantakis E, Dokianakis DN, Sourvinos G, Spandidos DA: Human papillomavirus infection of non-melanoma skin cancers in immunocompetent hosts. Cancer Lett 2000;161:83–88.
5.
Wieland U, Ritzkowsky A, Stoltidis M, Weissenborn S, Stark S, Ploner M, Majewski S, Jablonska S, Pfister HJ, Fuchs PG: Papillomavirus DNA in basal cell carcinomas of immunocompetent patients: An accidental association. J Invest Dermatol 2000;115:124–128.
6.
Baldursson BT, Beitner H, Syrjanen S: Human papillomavirus in venous ulcers with and without squamous cell carcinoma. Arch Dermatol Res 2000;292:275–278.
7.
Ferrandiz C, Fuente MJ, Ariza A, Ribera M, Paradelo C: Detection and typing of human papillomavirus in skin lesions from renal transplant recipients and equivalent lesions from immunocompetent patients. Arch Dermatol 1998;134:381–382.
8.
Arends MJ, Benton EC, McLaren KM, Stark LA, Hunter JA, Bird CC: Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy. Br J Cancer 1997;75:722–728.
9.
de Villiers EM, Lavergne D, McLaren K, Benton EC: Prevailing papillomavirus types in non-melanoma carcinomas of the skin in renal allograft recipients. Int J Cancer 1997;73:356–361.
10.
McGregor JM, Proby CM: The role of papillomaviruses in human non-melanoma skin cancer. Cancer Surv 1996;26:219–236.
11.
Shamanin V, zur Hausen H, Lavergne D, Proby CM, Leigh IM, Neumann C, Hamm H, Goos M, Haustein UF, Jung EG, et al: Human papillomavirus infections in nonmelanoma skin cancers from renal transplant recipients and nonimmunosuppressed patients. J Natl Cancer Inst 1996;88:802–811.
12.
de Villiers EM: Human papillomavirus infections in skin cancers. Biomed Pharmacother 1998;52:26–33.
13.
de Villiers EM, Ruhland A, Sekaric P: Human papillomaviruses in non-melanoma skin cancer. Semin Cancer Biol 1999;9:413–422.
14.
Ibe M, Kawase M, Ishiji T, Kamide R, Niimura M: A cardiac allograft recipient with Bowen’s disease on a finger and concurrent perianal bowenoid papulosis. J Dermatol 2003;30:389–394.
15.
Mitsuishi T, Kawashima M, Matsukura T, Sata T: Human papillomavirus type 58 in Bowen’s disease of the elbow. Br J Dermatol 2001;144:384–386.
16.
Uezato H, Hagiwara K, Ramuzi ST, Khaskhely NM, Nagata T, Nagamine Y, Nonaka S, Asato T, Oshiro M: Detection of human papilloma virus type 56 in extragenital Bowen’s disease. Acta Derm Venereol 1999;79:311–313.
17.
Pham-Huu V, Derancourt C, Clavel C, Durlach A, Birembaut P, Bernard P: Papillomavirus humains et maladie de Bowen acrale. Ann Dermatol Vénéréol 1999;126:808–812.
18.
Ota M, Kawashima M, Mitsuishi T: Multiple Bowen’s disease of the fingers. Eur J Dermatol 2002;12:275–277.
19.
Forslund O, Nordin P, Andersson K, Stenquist B, Hansson BG: DNA analysis indicates patient-specific human papillomavirus type 16 strains in Bowen’s disease on fingers and in archival samples from genital dysplasia. Br J Dermatol 1997;136:678–682.
20.
Mitsuishi T, Sata T, Matsukura T, Iwasaki T, Kawashima M: The presence of mucosal human papillomavirus in Bowen’s disease of the hands. Cancer 1997;79:1911–1917.
21.
Nordin P, Stenquist B, Hansson BG: Joint occurrence of human papillomavirus type 16 DNA in Bowen’s disease on a finger and in dysplasia of the vulva and the uterine cervix. Br J Dermatol 1994;131:740.
22.
McGrae JD Jr, Greer CE, Manos MM: Multiple Bowen’s disease of the fingers associated with human papilloma virus type 16. Int J Dermatol 1993;32:104–107.
23.
Cordoliani F, Eyraud-Reille D, Abirached G, Verola O, Puissant A, Morel P: Maladie de Bowen périunguéale associée au papillomavirus 16. Ann Dermatol Vénéréol 1992;119:905–906.
24.
Lambiase MC, Gardner TL, Altman CE, Albertini JG: Bowen disease of the nail bed presenting as longitudinal melanonychia: Detection of human papillomavirus type 56 DNA. Cutis 2003;72:305–309.
25.
Derancourt C, Mougin C, Chopard Lallier M, Coumes-Marquet S, Drobacheff C, Laurent R: Papillomavirus humains oncogènes révélés par technique d’hybridation in situ dans la maladie de Bowen extra-génitale. Ann Dermatol Vénéréol 2001;128:715–718.
26.
Lampert A, Pauwels C, Duboucher C, Morel G, Poveda JD, Perie G: Détection de papillomavirus humains dans la maladie de Bowen cutanée extragénitale chez le sujet immunocompétent. Ann Dermatol Vénéréol 2000;127:40–45.
27.
Clavel CE, Pham Huu V, Durlach A, Birembaut P, Bernard P, Derancourt C: Mucosal oncogenic human papillomaviruses and extragenital Bowen disease. Cancer 1999;15;86:282–287.
28.
Deguchi M, Tomioka Y, Mizugaki M, Tagami H: Detection of human papillomavirus type 33 DNA in extragenital Bowen’s disease with the polymerase chain reaction. Dermatology 1998;196:292–294.
29.
Lu S, Sÿrjanen K, Havu VK, Sÿrjanen S: Failure to demonstrate human papillomavirus (HPV) involvement in Bowen’s disease of the skin. Arch Dermatol Res 1996;289:40–45.
30.
Rübben A, Baron JM, Grussendorf-Conen El: Prevalence of human papillomavirus type 61-related DNA in cutaneous Bowen’s disease and squamous cell cancer. Int J Oncol 1996;9:609–611.
31.
Collina G, Rossi E, Bettelli S, Cook MG, Cesinaro AM, Trentini GP: Detection of human papillomavirus in extragenital Bowen’s disease using in situ hybridization and polymerase chain reaction. Am J Dermatopathol 1995;17:236–241.
32.
Venuti A, Donati P, Amantea A, Balus L: Human papillomavirus in non-genital Bowen’s disease and bowenoid carcinoma. Eur J Dermatol 1994;4:142–147.
33.
Kettler AH, Rutledge M, Tschen JA, Buffone G: Detection of human papillomavirus in nongenital Bowen’s disease by in situ DNA hybridization. Arch Dermatol 1990;126:777–781.
34.
Kawashima M, Favre M, Obalek S, Jablonska S, Orth G: Premalignant lesions and cancers of the skin in the general population: Evaluation of the role of human papillomaviruses. J Invest Dermatol 1990;95:537–542.
35.
Kawashima M, Jablonska S, Favre M, Obalek S, Croissant O, Orth G: Characterization of a new type of human papillomavirus found in a lesion of Bowen’s disease of the skin. J Virol 1986;57:688–692.
36.
Mitsuishi T, Kawana S, Kato T, Kawashima M: Human papillomavirus infection in actinic keratosis and Bowen’s disease: Comparative study with expression of cell-cycle regulatory proteins p21 (Waf1/Cip1), p53, PCNA, Ki-67, and Bcl-2 in positive and negative lesions. Hum Pathol 2003;34:886–892.
37.
Forslund O, Ly H, Reid C, Higgins G: A broad spectrum of human papillomavirus types is present in the skin of Australian patients with non-melanoma skin cancers and solar keratosis. Br J Dermatol 2003;149:64–73.
38.
Zur Hausen H: Papillomaviruses in human cancer. Cancer 1987;15:1692–1696.
39.
Bosch FX, Manos MM, Munoz N, Sherman M, Jansen AM, Peto J, et al: Prevalence of human papillomavirus in cervical cancer: A worldwide perspective. J Natl Cancer Inst 1995;87:796–802.
40.
Moerman M, Danielides VG, Nousia CS, Van Wanzeele F, Forsyth R, Vermeersch H: Recurrent focal epithelial hyperplasia due to HPV13 in an HIV-positive patient. Dermatology 2001;203:339–341.
41.
Meyer T, Arndt R, Christophers E, Stockfleth E: Frequency and spectrum of HPV types detected in cutaneous squamous-cell carcinomas depend on the HPV detection system: A comparison of four PCR assays. Dermatology 2000;201:204–211.
42.
Sass U, Theunis A, Noel JC, Andre J, Song M: Multiple HPV-positive basal cell carcinomas on the abdomen in a young pregnant woman. Dermatology 2002;204:362–364.
43.
Majewski S, Jablonska S: Human papillomavirus-associated tumors of the skin and mucosa. J Am Acad Dermatol 1997;36:659–685.
44.
Parant E, Jumbou O, Dantal J, Hourmant M, Dreno B: Viruses involved in allograft recipients’ cutaneous carcinomas. Ann Dermatol Vénéréol 2001;128:871–875.
45.
Stark LA, Arends MJ, McLaren KM, Benton EC, Shahidullah H, Hunter JA, Bird CC: Prevalence of human papillomavirus DNA in cutaneous neoplasms from renal allograft recipients supports a possible viral role in tumour promotion. Br J Cancer 1994;69:222–229.
46.
Soler C, Chardonnet Y, Allibert P, Euvrard S, Schmitt D, Mandrand B: Detection of mucosal human papillomavirus types 6/11 in cutaneous lesions from transplant recipients. J Invest Dermatol 1993;101:286–291.
47.
Baay MF, Quint WG, Koudstaal J, Hollema H, Duk JM, Burger MP, Stolz E, Herbrink PJ: Comprehensive study of several general and type-specific primer pairs for detection of human papillomavirus DNA by PCR in paraffin-embedded cervical carcinomas. J Clin Microbiol 1996;34:745–747.
48.
Antonsson A, Forslund O, Ekberg H, Sterner G, Hansson BG: The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a commensal nature of these viruses. J Virol 2000;74:11636–11641.
49.
Astori G, Lavergne D, Benton C, Hockmayr B, Egawa K, Garbe C, de Villiers EM: Human papillomaviruses are commonly found in normal skin of immunocompetent hosts. J Invest Dermatol 1998;110:752–755.
50.
Orth G, Favre M, Majewski S, Jablonska S: Epidermodysplasia verruciformis defines a subset of cutaneous human papillomaviruses. J Virol 2001;75:4952–4953.
51.
Majewski S, Jablonska S: Epidermodysplasia verruciformis as a model of human papillomavirus-induced genetic cancer of the skin. Arch Dermatol 1995;131:1312–1318.
52.
Ishiji T, Ibe M, Kawase M, Niimura M: Patients with epidermodysplasia verruciformis show no response to contact immunotherapy. Dermatology 2001;202:76–77.
53.
Boxman IL, Mulder LH, Russell A, Bouwes Bavinck JN, Green A, ter Schegget J: Human papillomavirus type 5 is commonly present in immunosuppressed and immunocompetent individuals. Br J Dermatol 1999;141:246–249.
54.
Boxman IL, Russell A, Mulder LH, Bavinck JN, Schegget JT, Green A: Case-control study in a subtropical Australian population to assess the relation between non-melanoma skin cancer and epidermodysplasia verruciformis human papillomavirus DNA in plucked eyebrow hairs. The Nambour Skin Cancer Prevention Study Group. Int J Cancer 2000;86:118–121.
55.
Boxman IL, Russell A, Mulder LH, Bavinck JN, ter Schegget J, Green A, Collaborators of the Nambour Prevention Study: Association between epidermodysplasia verruciformis-associated human papillomavirus DNA in plucked eyebrow hair and solar keratoses. J Invest Dermatol 2001;117:1108–1112.
56.
Favre M, Orth G, Majewski S, Baloul S, Pura A, Jablonska S: Psoriasis: A possible reservoir for human papillomavirus type 5, the virus associated with skin carcinomas of epidermodysplasia verruciformis. J Invest Dermatol 1998;110:311–317.
57.
Favre M, Majewski S, Noszczyk B, Maienfisch F, Pura A, Orth G, Jablonska S: Antibodies to human papillomavirus type 5 are generated in epidermal repair processes. J Invest Dermatol 2000;114:403–407.
58.
Jablonska S, Majewski S: Epidermodysplasia verruciformis: Immunological and clinical aspects. Curr Top Microbiol Immunol 1994;186:157–175.
59.
Padlewska K, Ramoz N, Cassonnet P, Riou G, Barrois M, Majewski S, Croissant O, Jablonska S, Orth G: Mutation and abnormal expression of the p53 gene in the viral skin carcinogenesis of epidermodysplasia verruciformis. J Invest Dermatol 2001;117:935–942.
60.
Purdie KJ, Pennington J, Proby CM, Khalaf S, de Villiers EM, Leigh IM, Storey A: The promoter of a novel human papillomavirus (HPV77) associated with skin cancer displays UV responsiveness, which is mediated through a consensus p53 binding sequence. EMBO J 1999;18:5359–6539.
61.
Jackson S, Harwood C, Thomas M, Banks L, Storey A: Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins. Genes Dev 20001;14:3065–3073.
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