Background: Nicotine was effective in the treatment of skin disorders attributable to neutrophils such as pyoderma gangrenosum and orogenital ulcerations due to Behçet’s disease. Objective: We assessed the efficacy of nicotine for treating skin disorders with prominent eosinophilic infiltration. Patients and Methods: A 67-year-old man with Kimura’s disease was treated for 2 weeks with nicotine chewing gum (6 mg/day). A 50-year-old woman with erythema nodosum with eosinophilic infiltration was treated for 4 weeks with transdermal nicotine patches (5 mg/day). Results: Both patients showed a dramatic clinical and histopathological improvement. Conclusion: Our results suggest that nicotine may be useful for treating skin disorders with eosinophilic infiltration as well as neutrophilic dermatoses.

Keywords:
Nicotine, Eosinophil, Kimura’s disease, Erythema nodosum
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2004
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