We report an 11-year follow-up of a case of granulomatous slack skin. The patient was first treated surgically followed by a rapid relapse. Then he was treated by α-interferon during 15 months. When this treatment was stopped, the disease relapsed again. Extensive surgery was undertaken. Recently, a new relapse has occurred which was again treated by extensive surgery. No other manifestation of a lymphoproliferative disorder appeared. The clinical, histological, immunohistochemical, ultrastructural, molecular biological and genetic studies with a review of 39 other cases described in the literature are presented.

Keywords:
Granulomatous slack skin, Cutaneous T-cell lymphoma
1.
Convit J, Kerdel F, Goihman MM, Rondon AJ, Soto JM: Progressive atrophying granulomatous dermohypodermitis. Arch Dermatol 1973;107:271–274.
2.
Ackerman AB: Granulomatous slack skin; in Ackerman AB (ed): Histologic Diagnosis of Inflammatory Skin Diseases. Philadelphia, Lea & Febiger, 1978, pp 483–485.
3.
Leboit PE, Zackeim HE, White CR Jr: Granulomatous variants of cutaneous T-cell lymphoma. Am J Surg Pathol 1988;12:83–95.
4.
Leboit PE, Backstead JH, Bond B, Epstein WL, Friede IJ, Parslow TG: Granulomatous slack skin: Clonal rearrangement of the proliferative nature of a cutaneous elastolytic disorder. J Invest Dermatol 1987;89:183–186.
5.
Willemze R, Meijer CJLM: EORTC classification for primary cutaneous lymphomas: The best guide to good clinical management. Am J Dermatopathol 1999;21:265–273.
6.
Balus L, Manente L, Remotti D, Grammattico P, Bellocci M: Granulomatous slack skin – Report of a case and review of the literature. Am J Dermatopathol 1996;18:199–206.
7.
Van Haselen CW, Toonstra J., Van der Putte SJC, et al: Granulomatous slack skin: Report of three patients with an updated review of the literature. Dermatology 1998;196:382–391.
8.
Kono T, Nagayasu TS, Nakanishi T, et al: Granulomatous slack skin: Successful treatment with recombinant interferon-gamma. Br J Dermatol 2000;142:353–357.
9.
Kanthilatha P, Ravikala R, Rama D, et al: Granulomatous slack skin. Int J Dermatol 2000;39:363–382.
10.
Chen M, Qiu B, Kong J: Granulomatous slack skin: A case of unusual variant of mycosis fungoides. Chin Med J 2000;113:189–192.
11.
Scarabello A, Leinweber B, Ardigo M, et al: Cutaneous lymphomas with prominent granulomatous reaction. Am J Surg Pathol 2002;26:1259–1268.
12.
Tsuruta D, et al: Granulomatous slack skin: An ultrastructural study. J Cutan Pathol 2001;28:44–48.
13.
Grammatico P, Balus L, Scarpa S, et al: Granulomatous slack skin: Cytogenetic and molecular analyses. Cancer Genet Cytogenet 1994;72:96–100.
14.
Helm KF, Cerio R, Winckelman RK: Granulomatous slack skin: A clinicopathological and immunohistological study of three cases. Br J Dermatol 1992;126:142–147.
15.
De Gregorio R, Fenske N, Glass L: Granulomatous slack skin: A possible precursor of Hodgkin’s disease. J Am Acad Dermatol 1995;33:1044–1047.
16.
Bazex A, Dupré A, Christol B: Maladie de Besnier-Boeck-Schaumann chalazodermique? Bull Soc Fr Dermatol Syphiligr 1968;75:448–450.
17.
Le T, Piérard G: Granulomatous slack skin syndrome and Hodgkin’s disease. Ital Gen Rev Dermatol 1986;23:48–49.
18.
Alessi E, Crosti C, Sala F: Unusual case of granulomatous dermohypodermitis with giant cells and elastophagocytosis. Dermatologica 1986;172:218–221.
19.
Bournerias I, Bosq J, Avril MF, et al: Maladie de Hodgkin, mycosis fongoïde avec réaction sarcoïdosique et chalazodermie granulomateuse. Ann Dermatol Vénéréol 1986;113:933–938.
20.
Jomaa B, Morini JP, Jaafoura MH, et al: Lymphome cutané épidermotrope associé à une chalazodermie granulomateuse. Ann Dermatol Vénéréol 1987;114:1402–1405.
21.
Konrad K: Granulomatous slack skin (abstract). Hautarzt 1987;38:243.
22.
Marien K, de Wolf-Peeters C, de Greef H, Swinnen C: Granulomatous slack skin; in Wilkinson DS (ed): Clinical Dermatology: The CMD Case Collection. World Congress of Dermatology, Berlin, May 22–29, 1987. Stuttgart, Schattauer, 1987, pp 375–376.
23.
Randle HW, Banks PM, Winkelmann RK: Cutaneous granulomas in malignant lymphoma. Arch Dermatol 1980;116:441.
24.
University of Michigan Staff: Granulomatous dermatochalasia. Int J Dermatol 1979;18:512.
25.
Benisovich V, Papadopoulos E, Amorosi EL, et al: The association of progressive, atrophying, chronic, granulomatous dermohypodermitis with Hodgkin’s disease. Cancer 1988;62:2425–2429.
26.
Kauffmann CL, Nigra TP, Friedman KJ: A case of granulomatous slack skin (abstract). J Cutan Pathol 1988;15:319.
27.
Kantor RJ, Chung G: Granulomatous slack skin. J Am Acad Dermatol 1991;25:138–140.
28.
Guerra A, Borrego L, Romero G, Ballestin C: Granulomatous slack skin syndrome and histiocytosis X. 18th World Congr Dermatol, New York, 1992, abstract 82A.
29.
Puig S, Iranzo P, Palou J, et al: Lymphoproliferative nature of granulomatous slack skin: Clonal rearrangement of the T-cell receptor B-gene. Arch Dermatol 1992;128:562–563.
30.
Babin MMB, Tamisier JM, Gauthier O: Anétodermie chalazodermique giganto-cellulaire. Bull Soc Fr Dermatol Syphiligr 1974;83:194.
31.
Cockerell CJ, Stetler LA, Cavenangh D: Concomitant poikiloderma vasculare atrophicans, granulomatous mycosis fungoides and granulomatous slack skin syndrome: Demonstration of a disease spectrum. 52nd Annu Meet Am Acad Dermatol, Washington, December 1993, poster P-207.
32.
Tsang WYW, Chan JKC, Loo KT, Wong KF, Lee AW: Granulomatous slack skin. Histopathology 1994;25:49–55.
33.
Von den Driesch P, Mielke V, Simon M Jr, et al: Granulomatous slack skin – Kutanes elastolytisches Lymphom. Hautarzt 1994;45:861–864.
34.
Noto G, Pravata G, Miceli S, Arico M: Granulomatous slack skin: Report of a case associated with Hodgkin’s disease and a review of the literature. Br J Dermatol 1994;131:275–279.
35.
Mouly F, Baccard M, Cayuela JM, et al: Cutaneous T-cell lymphoma associated with granulomatous slack skin. Dermatology 1996;192:288–290.
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2003
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