We report 2 patients who had sarcoidosis with skin involvement associated with bilateral anterior uveitis. During the follow-up, they developed chronic myelomonocytic leukemia. This association is of particular interest as sarcoidosis and chronic myelomonocytic leukemia may be considered as disorders of a common monocyte-macrophage cell lineage.

Keywords:
Chronic myelomonocytic leukemia, Sarcoidosis
1.
Sawanobori M, Nakagawa Y, Inoue Y, Suzuki K, Shinohar T, Takemura T: Chronic myelomonocytic leukemia developed 7 years after the onset of idiopathic thrombocytopenic purpura-like syndrome. Rinsho Ketsueki 1997;38:222–227.
2.
Viallard JF, Marit G, Reiffers J, Broustet A, Parrens M: Antiphospholipid syndrome during chronic myelomonocytic leukemia. Am J Hematol 2000;63:60.
3.
Disdier P, Harlé JR, Herbault GF, Chrestian MA, Horchowski N, Mongin M, Weiller PJ: Panniculite du grand épiploon: complication exceptionnelle d’une leucémie myélomonocytaire chronique. Ann Méd Interne 1990;141:283–285.
4.
Kaddu S, Zenalik P, Beham-Schmid C, Kerl H, Cerroni L: Specific cutaneous infiltrates in patients with myelogenous leukemia: A clinicopathologic study of 26 patients with assessment of diagnostic criteria. J Am Acad Dermatol 1999;40:966–978.
5.
Avivi I, Rosenbaum H, Levy Y, Rowe J: Myelodysplastic syndrome and associated skin lesions: A review of the literature. Leuk Res 1999;23:323–330.
6.
Tzvara V, Stamoulis K, Aroni KG, Kordossis T, Boki KA: Facial heliotrope rash as an initial manifestation of acute myelomonocytic leukemia. Leuk Lymphoma 1997;25:393–398.
7.
Huilgoll SC, Lidell K, Black MM: Generalized granuloma annulare sparing vaccination sites. Clin Exp Dermatol 1995;20:51–53.
8.
Wijetunga JG, Mitchell TR, Black PD: Chronic myelomonocytic leukemia presenting as a keratouveitis. Ann Ophthalmol 1986;18:199–200.
9.
Pagano L, Visani G, Ferrara F, Cenacchi A, Bonini A, Equitani F, Fuso L, Piscitelli R, Pagliari G: Contemporaneous acute myeloid leukemia and sarcoidosis: Report of three cases. Sarcoidosis Vasc Diffuse Lung Dis 1998;15:67–70.
10.
Krosi Z, Casassus P, Valeyre J, Paolaggi A, Amouroux J, Battesti JP: Leucémie myéloïde chronique dans l’évolution d’une sarcoïdose. Rev Pneumol Clin 1988;44:33–35.
11.
Malisel F, Oderling F: Acute myeloid leukemia complicating sarcoidosis. J R Soc Med 1992;85:58–59.
12.
Hermann C, Andersen E, Videbaek A: Acute myeloblastic leukemia in sarcoidosis treated with methotrexate. Scand J Haematol 1980;24:234–236.
13.
Pietropaoli A, Modrack J, Utell M: Interferon therapy associated with the development of sarcoidosis. Chest 1999;116:569–572.
14.
Tauro S, Mahendra P: Resolution of sarcoidosis after allogenic bone marrow transplantation with donor lymphocyte infusions. Bone Marrow Transplant 2001;27:757–759.
15.
Hatake K, Aoyagi N, Takaku F: Acute myelomonocytic leukemia following remission of sarcoidosis. Oncology 1983;40:200–201.
16.
Tomasini C, Quaglino P, Novelli M, Fierro MT: ‘Aleukemic’ granulomatous leukemia cutis. Am J Dermatopathol 1998;20:417–421.
17.
Reich JM: Sarcoidosis and agnogenic myeloid metaplasia. J Intern Med 1994;235:175–178.
18.
Ng T, Yeghen T, Pagliuca A, Gillett DS, Mutti GJ: Non caseating granulomata associated with hypocellular myelodysplastic syndrome. Leuk Lymph 2000;39:397–403.
19.
Casassus P, Vannetzel JM, Experton B, Valeyre D, Brun B, Teillet F, Turpin F, Lortholary P, Battesti JP: Association lymphomes malins sarcoïdose. Press Méd 1982;11:2339–2342.
20.
Linnenberg HS, Medici TC, Rhyner K: The sarcoidosis-lymphoma syndrome, a lymphocyte dysregulation. Pneumologie 1992;46:229–235.
21.
Yajima A, Kawada A, Aragane Y, Tezuka T: Detection of HTLV-1 proviral DNA in sarcoidosis. Dermatology 2001;203:53–56.
22.
Uchiumi H, Murakami H, Matsushima T, Tamura J, Sawamura M: Does sarcoidosis induce multiple myeloma? Am J Hematol 1993;44:220.
23.
Nagata T, Mugishima H, Yoden A, Yoshikawa K, Oguni T, Tamashiro K, Yamamori S, Harada K: A case of monoclonal gammopathy associated with acute myelomonocytic leukemia with eosinophilia suggested to be the result of lineage infidelity. Am J Hematol 2000;65:66–71.
24.
Cline MJ: Histiocytes and histiocytosis. Blood 1994;84:2840–2853.
© 2002 S. Karger AG, Basel
2002
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.