Abstract
We report the case of a 56-year-old HIV-seropositive man who presented a facial Demodex infection developed 2 months after initiation of highly active antiretroviral therapy. The Demodex infection was confirmed by scrapings and histopathologic examination and by the dramatic response to antiparasitic treatment with oral ivermectin associated with 5% permethrin cream.
References
1.
Nutting WB: Hair follicle mites (Acari: Demodicidae) of man. Int J Dermatol 1976;15:79–98.
2.
Bonnar E, Eustace P, Powell FC: Demodex mite in normal skin. Lancet 1991;337:1168.
3.
Forton F, Seys B: Density of Demodex folliculorum in rosacea: A case-control study using standardized skin surface biopsy. Br J Dermatol 1993;128:650–659.
4.
Bonnar E, Eustace P, Powell FC: The Demodex mite population in rosacea. J Am Acad Dermatol 1993;28:443–448.
5.
Marks R, Harcourt-Webster JN: Hiostopathology of rosacea. Arch Dermatol 1969;100:683–691.
6.
Ramelet AA, Perroulaz G: Rosacea: Histopathologic study of 75 cases. Ann Dermatol Vénéréol 1988;115:801–806.
7.
Roihu T, Kariniemi AL: Demodex mites in acne rosacea. J Cutan Pathol 1998;25:550–552.
8.
Ayres S Jr: Pityriasis folliculorum (Demodex). Arch Dermatol Syphilil 1930;21:19–24.
9.
Miskjian HG: Demodiciodis (Demodex infestation of the scalp). Arch Dermatol 1951;63:282–283.
10.
Purcell SM, Hayes TJ, Dixon SL: Pustular folliculitis associated with Demodex folliculorum. J Am Acad Dermatol 1986;15:1159–1162.
11.
Ayres S, Ayres S III: Demodectic eruptions (demodicidosis) in the human: Thirty years’ experience with two commonly unrecognized entities: Pityriasis folliculorum (Demodex) and acne rosacea (Demodex type). Arch Dermatol 1961;83:816–824.
12.
Ecker RI, Winkelmann RK: Demodex granuloma. Arch Dermatol 1979;115:343–344.
13.
Aydingoz IE, Mansur T, Dervent B: Demodex folliculorum in renal transplant patients. Dermatology 1997;195:232–234.
14.
Sahn EE, Sheridan DM: Demodicidosis in a child with leukemia. J Am Acad Dermatol 1992;27:799–801.
15.
Ivy SP, Mackall CL, Gore L, Gress RE, Hartley H: Demodicidosis in childhood acute lymphoblastic leukemia: An opportunistic infection occurring with immunosuppression. J Pediatr 1995;127:751–754.
16.
Castanet J, Monpoux F, Mariani R, Ortonne JP, Lacour JP: Demodicidosis in an immunodeficient child. Pediatr Dermatol 1997;14:219–220.
17.
Nakagawa T, Sasaki M, Fujita K, Nishimoto M, Takaiwa T: Demodex folliculitis on the trunk of a patient with mycosis fungoides. Clin Exp Dermatol 1996;21:148–150.
18.
Dominey A, Rosen T, Tschen J: Papulonodular demodicidosis associated with acquired immunodeficiency syndrome. J Am Acad Dermatol 1989;20:197–201.
19.
Ashack RJ, Frost ML, Norins AL: Papular pruritic eruption of Demodex folliculitis in patients with acquired immunodeficiency syndrome. J Am Acad Dermatol 1989;21:306–307.
20.
Banuls J, Ramon D, Aniz E, Jorda E, Torres V: Papular pruritic eruption with human immunodeficiency virus infection. Int J Dermatol 1991;11:801–803.
21.
Girault C, Borsa-Lebas F, Lecomte F, Humbert G: Eruption papulo-nodulaire: démodécie au cours du syndrome d’immunodéficience acquise. Press Méd 1991;20:177.
22.
Sanchez-Viera M, Hernanz JM, Sampelayo T, Gurbindo MD, Lecona M, Soto-Melo J: Granulomatous rosacea in a child infected with the human immunodeficiency virus. J Am Acad Dermatol 1992;27:1010–1011.
23.
De Jaureguiberry JP, Carsuzaa F, Pierre C, Arnoux D, Jaubert D: Demodex folliculitis: A cause of pruritus in human immunodeficiency virus infection. Ann Méd Interne (Paris) 1993;144:63–64.
24.
Redondo Mateo J, Soto Guzman O, Fernandez Rubio E, Dominguez Franjo F: Demodex-attributed rosacea-like lesions in AIDS. Acta Derm Venereol 1993;73:437.
25.
Barrio J, Lecona M, Hernanz JM, Sanchez M, Gurbindo MD, Lazaro P, et al: Rosacea-like demodicosis in an HIV-positive child. Dermatology 1996;192:143–145.
26.
Sarro RA, Hong JJ, Elgart ML: An unusual demodicidosis manifestation in a patient with AIDS. J Am Acad Dermatol 1998;38:120–121.
27.
Patrizi A, et al: Demodicidosis in a child infected with acquired immunodeficiency virus. Eur J Pediatr Dermatol 1999;9:25–28.
28.
Jansen T, Kastner U, Kreuter A, Altmeyer P: Rosacea-like demodicidosis associated with acquired immunodeficiency syndrome. Br J Dermatol 2001;144:139–142.
29.
Brown KR, Ricci FM, Ottesen EA: Ivermectin: Effectiveness in lymphatic filariasis. Parasitology 2000;121:S133–146.
30.
Currie B, Huffam S, O’Brien D, Walton S: Ivermectin for scabies. Lancet 1997;350:1551.
31.
Usha V, Gopalakirshnan Nair TV: A comparative study of oral ivemectin and topical permethrin cream in the treatment of scabies. J Am Acad Dermatol 2000;42:236–240.
32.
Paasch U, Haustein UF: Treatment of endemic scabies with allethrin, permethrin and ivermectin: Evaluation of a treatment strategy. Hautarzt 2001;52:31–37.
33.
Forstinger C, Kittler H, Binder M: Treatment of rosacea-like demodicidosis with oral ivermectin and topical permethrin cream. J Am Acad Dermatol 1999;41:775–777.
© 2002 S. Karger AG, Basel
2002
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