Background: The mechanism for ultraviolet-B (UVB)-associated cutaneous erythema may involve production of tumor necrosis factor α (TNF-α). Pentoxifylline inhibits TNF-α production. Objective: To assess the effect of oral pentoxifylline on UVB-induced erythema in humans. Methods: Baseline minimum erythema doses (MEDs) for UVB were measured. Subjects received pentoxifylline 400 mg orally every 8 h for 4 doses. MED assays were repeated 2 h after the last dose of pentoxifylline. Pre- and posttreatment MED results were assessed by the paired t test. Results: Oral administration of pentoxifylline to 7 normal adults elevated the MED for UVB in all 7 individuals. Conclusion: Pentoxifylline may diminish the cutaneous sunburn response to UVB radiation when it is administered prior to ultraviolet exposure.

Skov L, Hansen H, Allen M, Villadsen L, Norval M, Barker JN, Simon J, Baadsgaard O: Contrasting effects of ultraviolet A1 and ultraviolet B exposure on the induction of tumour necrosis factor-alpha in human skin. Br J Dermatol 1998;138:216–220.
Schwarz A, Bhardwaj R, Aragane Y, Mahnke K, Riemann H, Metze D, Luger TA, Schwarz T: Ultraviolet-B-induced apoptosis of keratinocytes: Evidence for partial involvement of tumor necrosis factor-α in the formation of sunburn cells. J Invest Dermatol 1995;104:922–927.
Zhuang L, Wang B, Shinder GA, Shivji GM, Mak TW, Sauder DN: TNF receptor p55 plays a pivotal role in murine keratinocyte apoptosis induced by ultraviolet B irradiation. J Immunol 2000;162:1440–1447.
Dormandy JA: Pharmacologic treatment of venous leg ulcers. J Cardiovasc Pharmacol 1995;25(suppl 2):S61–S65.
Samlaska CP, Winfield EA: Pentoxifylline. J Am Acad Dermatol 1994;30:603–621.
Oberyszyn TM, Tober KL, Ross MS, Robertson FM: Inhbitory effects of pentoxifylline on ultraviolet B light-induced cutaneous inflammation. Mol Carcinog 1998;22:16–25.
Strieter RM, Remick DG, Ward PA, Spengler RN, Lyncy JP, Larrick J, Kunkel SL: Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem Biophys Res Commun 1988;155:1230–1236.
Sullivan GW, Carper HT, Novick WJ, Mandell GL: Inhibition of the inflammatory action of interleukin-1 and tumor necrosis factor (alpha) on neutrophil function by pentoxifylline. Infect Immun 1988;56:1722–1729.
Schwarz A, Mahnke K, Luger TA, Schwarz T: Pentoxifylline reduces the formation of sunburn cells. Exp Dermatol 1997;6:1–5.
Morison WL (ed): Phototherapy and Photochemotherapy of Skin Disease, ed 2. New York, Raven Press, 1991.
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