Background: Skin anatomy and physiology undergo modifications throughout the whole lifespan. In children the skin appears with structural characteristics, as evaluated by histology, which differ from those of adults, especially in the first years of life. Objective: The aim of our study was to evaluate skin thickness and echogenicity at different sites in children by 20-MHz ultrasound. Methods: Eight skin sites of 42 children and 30 young adults were studied with a 20-MHz B scanner. Skin thickness and mean echogenicity were evaluated. The echographic images were processed and segmented by a dedicated program: the 0–30 amplitude interval, which marks the hypoechogenic parts of the tissue, and the 201–255 range, highlighting the hyperreflecting areas, have been selected. Results and Conclusion: Whereas skin thickness shows a gradual increase from birth to adulthood, maturation of the skin leads to variations in the intensity of its echogenicity, depending on the different skin areas. Whereas on the face and the trunk it appears lower in adults with respect to children, a gradual increase can be observed on the limbs with growing age. The distribution of skin reflectivity also greatly varies in different phases of life.

1.
Marks R, Edwards C: The measurement of photodamage. Br J Dermatol 1992;127(suppl 41):7–13.
2.
Takema Y, Yorimoto Y, Kawai M, Imokawa G: Age-related changes in the elastic properties and thickness of human facial skin. Br J Dermatol 1994;131:641–648.
3.
Conti A, Schiavi ME, Seidenari S: Capacitance, transepidermal water loss and casual level of sebum in healthy subjects in relation to site, sex and age. Int J Cosmet Sci 1995;17:77–85.
4.
Quan MB, Edwards C, Marks R: Non-invasive in vivo techniques to differentiate photodamage and ageing in human skin. Acta Derm Venereol 1997;77:416–419.
5.
Takema Y, Tsukahara K, Fujimura T, Hattori M: Age-related changes in the three-dimensional morphological structure of human facial skin. Skin Res Technol 1997;3:95–100.
6.
de Rigal J, Escoffier C, Querleux B, Faivre B, Agache P, Leveque JL: Assessment of aging of the human skin by in vivo ultrasonic imaging. J Invest Dermatol 1989;93:621–625.
7.
Seidenari S, Pagnoni A, Di Nardo A, Giannetti A: Echographic evaluation with image analysis of normal skin: Variation according to age and sex. Skin Pharmacol 1995;7:201–209.
8.
Nopper AJ, Horil KA, Sookdeo-Drost S, Wang TH, Mancini AJ, Lane AT: Topical ointment therapy benefits premature infants. J Pediatr 1996;128:660–669.
9.
Holbrook KA, Sybert VP: Structural and biochemical properties of the skin of adults, children and newborn infants; in Schachner LA, Hansen RC (eds): Pediatric Dermatology, ed 2. New York, Churchill-Livingstone, 1995, pp 26–70.
10.
Seidenari S, Di Nardo A, Pepe P, Giannetti A: Ultrasound B scanning with image analysis for assessment of allergic patch test reactions. Contact Dermatitis 1991;24:216–222.
11.
Widdowson EM: Changes in the extracellular compartment of muscle and skin during normal and retarded development. Bibl Nutr Dieta 1969;13:60.
12.
Lasagni C, Seidenari S: Echographic assessment of age-dependent variations of skin thickness. A study on 162 subjects. Skin Res Technol 1995;1:81–85.
13.
Pellacani G, Seidenari S: Variations in facial skin thickness and echogenicity with site and age. Acta Derm Venereol 1999;79:366–369.
14.
Altmeyer P, Hoffmann H, Stücker M, Goertz S, el-Gammal S: General phenomena of ultrasound in dermatology; in Altmeyer P, el-Gammal S, Hoffmann H (eds): Ultrasound in Dermatology. Berlin, Springer, 1992, pp 55–79.
15.
Seidenari S, Di Nardo A: B scanning evaluation of irritant reactions with binary transformation and image analysis. Acta Derm Venereol (Stockh) 1992;suppl 175:9–13.
16.
Seidenari S, Belletti B: Instrumental evaluation of subclinical irritation induced by sodium lauryl sulfate. Contact Dermatitis 1994;30:175.
17.
Seidenari S: Echographic evaluation with image analysis of irritant reactions induced by nonanoic acid and hydrochloric acid. Contact Dermatitis 1994;31:146–150.
18.
Pellacani G, Francomano M, Giusti G, Seidenari S: Epidermal echogenicity as a hydration parameter: The effect of moisturizers on the skin as evaluated by 20 MHz ultrasound. J Soc Cosmet Chem 1997;48:243–251.
19.
Adamsic M, Fiser-Herman M: Über Veränderungen der chemischen Zusammensetzung der menschlichen Haut während des Kindesalters. Arch Klin Exp Dermatol 1967;7:229.
20.
Warren R, Gartstein V, Kligman AM, Montagna W, Allendorf RA, Ridder GM: Age, sunlight, and facial skin: A histologic and quantitative study. J Am Acad Dermatol 1991;25:751–760.
21.
Oikarinen A: Aging of the skin connective tissue: How to measure the biochemical and mechanical properties of aging dermis. Photodermatol Photoimmunol Photomed 1994;10:47–52.
22.
Braverman IM, Fonferko E: Studies in cutaneous aging. I. The elastic fiber network. J Invest Dermatol 1982;78:434–443.
23.
Richard S, Querleux B, Bittoun J, Jolivet O, Idy-Peretti I, Lacharriere O, Leveque JL: Characterization of the skin in vivo by high resolution magnetic resonance imaging: Water behavior and age-related effects. J Invest Dermatol 1993;100:705–709.
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