Abstract
Multiple and familial cases of pilomatrixomas have been reported in myotonic dystrophy. We report 2 cases of pilomatrixoma in Turner’s syndrome. Between 5 and 19 years of age, 1 patient developed 6 pilomatrixomas including atypical occurrences on the chest and the posterior aspect of the leg. This is the first report of multiple pilomatrixomas in Turner’s syndrome.
References
1.
Ullrich O: Über typische Kombinationsbilder multipler Abartungen. Z Kinderheilkd 1930; 49:271.
2.
Turner HH: A syndrome of infantilism, congenital webbed neck, and cubitus valgus. Endocrinology 1938;23:566–574.
3.
Ford CE: A sex-chromosome anomaly in a case of gonadal dysgenesis. Lancet. 1959;i: 711–713.
4.
DiGeorge AM: Hypergonadotropic hypogonadism in the female; in Behrman RE, Kliegman RM, Arvin AM, Nelson WE (eds): Nelson Textbook of Pediatrics, ed 15. Philadelphia, Saunders, 1996, pp 1635–1637.
5.
Harper J: Genetics and Genodermatoses: Turner’s syndrome; in Champion RH, Bulton JL, Ebling FJG (eds): Textbook of Dermatology, ed 5. London, Blackwell Scientific, 1992, pp 319–320.
6.
Cantwell AR Jr, Reed WB: Myotonia atrophica and multiple calcifying epithelioma of Malherbe. Acta Derm Venereol 1965;45:387–390.
7.
Harper PS: Calcifying epithelioma of Malherbe. Association with myotonic muscular dystrophy. Arch Dermatol 1972;106:41–44.
8.
Pujol RM, Casanova JM, Egido R, Pujol J, de Moragas JM: Multiple familial pilomatricomas: Cutaneous marker for Gardner syndrome? Pediatr Dermatol 1995;12:331–335.
9.
Cambiaghi S, Ermacora E, Brusasco A, Canzi L, Caputo R: Multiple pilomatricomas in Rubinstein-Taybi syndrome: A case report. Pediatr Dermatol 1994;11:21–25.
10.
Miller RW, Rubinstein JH: Tumors in Rubinstein-Taybi syndrome. Am J Med Genet 1995; 56:112–115.
11.
Masuno M: Pilomatrixomas in Rubinstein-Taybi syndrome (letter). Am J Med Genet 1998;77:81–82.
12.
Narisawa Y, Kohda H; Cutaneous cysts of Gardner’s syndrome are similar to follicular stem cells. J Cutan Pathol 1995;22:115–121.
13.
Petriji F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RCM, Masuno M, Tommerup N, van Ommen G-JB, Goodman RH, Peters DJM, Breuing MH: Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature 1995;376:348–351.
14.
Borrow J, Stanton VP Jr, Anderson JM, Becher R, Behm FG, Chaganti RSK, Civin CI, Disteche C, Dube I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE: The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyl-transferase to CREB-binding protein. Nat Genet 1996;14:33–41.
15.
Taki T, Sako M, Tsuchida M, Hayashi Y: The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene. Blood 1997;89:3945–3950.
16.
Moehlenbeck FW: Pilomatrixoma (calcifying epithelioma). Arch Dermatol 1973;108:532– 534.
17.
Noguchi H, Hayashibara T, Ono T: A statistical study of calcifying epithelioma, focusing on the site of origin. J Dermatol 1995;22:24–27.
© 2000 S. Karger AG, Basel
1999
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.