Background: Chronic urticaria is one of the most frequent skin diseases. Its cause, however, remains unsolved in a large number of cases. Recent investigations pointed to a potential role of Helicobacter pylori infection of the upper gastrointestinal tract as a possible causative agent in chronic urticaria. Objective: The aim of this study was to examine the effect of a 14-day eradication therapy on chronic urticaria. Methods: Thirty patients with chronic urticaria and confirmed H. pylori infection were treated with amoxicillin and omeprazole. Follow-up was conducted over a period of 6 months concerning eradication of H. pylori and remission of urticaria. Results: Only 8 out of 30 patients (26.7%) showed clinical improvement or disappearance of their urticarial symptoms. Conclusion: Though our results do not support the preliminary data of previous studies, the role of H. pylori as a possible bacterial focus of chronic urticaria has to be further investigated.

1.
Cooper KD: Urticaria and angioedema: Diagnosis and evaluation. J Am Acad Dermatol 1991;25:166–176.
2.
Greaves MW: Chronic urticaria. N Engl J Med 1995;332:1767–1772.
3.
Przybilla B: Urtikaria, Angioödem und Anaphylaxie; in Braun-Falco O, Plewig G, Wolff HH (eds): Dermatologie und Venerologie, ed 4. Berlin, Springer, 1995, pp 373–401.
4.
Stadelmann O: Spektrum der Helicobacter-pylori-assoziierten Erkrankungen; in Malfertheimer P (ed): Helicobacter pylori – Von der Grundlage zur Therapie. Stuttgart, Thieme, 1994, pp 39–54.
5.
Kolibasova K, Cervenkova D, Hegyi E, Lengyelova J, Tóth J: Helicobacter pylori – Ein möglicher ätiologischer Faktor der chronischen Urtikaria. Dermatosen 1994;42:235–236.
6.
Bohmeyer J, Heller A, Hartig C, Westenberger-Treumann M, Huchzermeyer H, Otte HG, Stadler R: Assoziation der chronischen Urtikaria mit Helicobacter-pylori-induzierter Antrum-Gastritis. Hautarzt 1996;74:106–108.
7.
Tebbe B, Geilen CC, Schulzke JD, Bojarski C, Radenhausen M, Orfanos CE: Helicobacter pylori infection and chronic urticaria. J Am Acad Dermatol 1996;34:685–686.
8.
Graham DY, Klein PD, Evans DJ, Evans DE, Alpert LC, Opekun AR, Boutton TW: Campylobacter pylori detected noninvasively by the 13C-urea breath test. Lancet 1987;i:1174–1177.
9.
Champion RH, Roberts OB, Carpenter RG, Roger JH: Urticaria and angio-oedema – A review of 554 patients. Br J Dermatol 1969;81: 588–597.
10.
Czarnetzki BM: Acute and chronic urticaria: Specific causes of reactions; in Czarnetzki BM (ed): Urticaria. Berlin, Springer, 1986, pp 32–43.
11.
Labenz J, Börsch G: Therapie der Helicobacter-pylori-Infektion. Dtsch Med Wochenschr 1994;119:669–672.
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