Abstract
Several viruses have been detected, at various frequencies, in Kaposi’s sarcoma (KS) tissues. The detection of human herpesvirus 8 (HHV-8) in all the epidemiological and histological forms of KS makes it the most attractive candidate causative agent to date. In this report, we discuss the possible explanations for the detection of genomic sequences of various viral agents in KS and the putative role of those viruses in the pathogenesis of the disease.
References
1.
Couturier E, Ancelle-Park RA, de Vincenzi I, Downs AM, Brunet JB: Kaposi’s sarcoma as a sexually transmitted disease. Lancet 1990;335: 1105.
2.
Beral V, Bull D, Darby S, Weller I, Carne C, Beecham M, Jaffe H: Risk of Kaposi’s sarcoma and sexual practices associated with faecal contact in homosexual or bisexual men with AIDS. Lancet 1992;339:632–635.
3.
Drew WL, Miner RC, Ziegler JL, Gullett JH, Abrams DI, Conant MA, Huang ES, Groundwater JR, Volberding P, Mintz L: Cytomegalovirus and Kaposi’s sarcoma in young homosexual men. Lancet 1982;ii:125–127.
4.
Siddiqui A: Hepatitis B virus DNA in Kaposi sarcoma. Proc Natl Acad Sci USA 1983;80: 4861–4864.
5.
Andersen CB, Karkov J, Bjerregaard B, Visfeldt J: Cytomegalovirus infection in classic, endemic and epidemic Kaposi’s sarcoma analysed by in situ hybridisation. APMIS 1991;99: 893–897.
6.
Mahoney SE, Duvic M, Nickoloff BJ, Minshall M, Smith LC, Griffiths CE, Paddock SW, Lewis DE: Human immunodeficiency virus (HIV) transcripts in HIV-related psoriasis and Kaposi’s sarcoma. J Clin Invest 1991;88: 174–185.
7.
Bovenzi P, Mirandola P, Secchiero P, Strumia R, Cassai E, Di Luca D: Human herpesvirus 6 (variant A) in Kaposi’s sarcoma. Lancet 1993; 341:1288–1289.
8.
Scinicariello F, Dolan MJ, Nedelcu I, Tyring SK, Hilliard JK: Occurrence of human papillomavirus and p53 gene mutation in Kaposi’s sarcoma. Virology 1994;203:153–157.
9.
Monini P, Rotola A, De Lellis L, Corallini A, Secchiero P, Albini A, Benelli R, Parravicini C, Barbanti-Brodano G, Cassai E: Latent BK virus infection and Kaposi’s sarcoma pathogenesis. Int J Cancer 1996;66:717–722.
10.
Noel JC, Andre J, Hermans P, Fayt I, Peny MO, De Thier F, Haot J, Burny A: Kaposi’s sarcoma: Evaluation of the role of human papillomaviruses. Arch Dermatol Res 1996;288: 786–788.
11.
Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS: Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 1994;266:1865–1869.
12.
Schalling M, Eukman M, Kaaya EE, Linde A, Biberfeld P: A role for a new herpesvirus (KSHV) in different forms of Kaposi’s sarcoma. Nat Med 1995;1:707–708.
13.
Noel JC, Hermans P, Andre J, Fayt I, Simonart T, Verhest A, Haot J, Burny A: Herpesvirus-like DNA sequences and Kaposi’s sarcoma: Relationship to epidemiology, clinical spectrum and histologic features. Cancer 1996;77: 2132–2136.
14.
Gao SL, Kingsley M, Li M, Zheng W, Parravicini C, Rinaldo C, Saah A, Phair J, Detels R, Chang Y, Moore P: Seroprevalence of Kaposi’s sarcoma-associated herpesvirus antibodies among Northern Americans and Italians with and without Kaposi’s sarcoma. Nat Med 1996;2:925–928.
15.
Sarid R, Sato T, Bohenzky RA, Russo JJ, Chang Y: Kaposi’s sarcoma-associated herpesvirus encodes a functional Bcl-2 homologue. Nat Med 1997;3:293–298.
16.
Cesarman E, Nador RG, Bai F, Bohenzky RA, Russo JJ, Moore PS, Chang Y, Knowles DM: Kaposi’s sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi’s sarcoma and malignant lymphoma. J Virol 1996; 70:8218–8223.
17.
Boshoff C, Endo Y, Collins PD, Takeuchi Y, Reeves JD, Schweickart VL, Siani MA, Sasaki T, Williams TJ, Gray PW, Moore PS, Chang Y, Weiss RA: Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines. Science 1997;278:290–294.
18.
Neipel F, Albrecht JC, Ensser A, Huang YQ, Li JJ, Frieman-Kien AE, Fleckenstein B: Human herpesvirus 8 encodes a homolog of interleukin-6. J Virol 1997;71:839–842.
19.
Boshoff C, Schulz TF, Kennedy MM, Graham KA, Fisher C, Thomas A, McGee JO’D, Weiss RA, O’Leary JJ: Kaposi’s sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med 1995;1:1274–1278.
20.
Simonart Th, Noel JC, Liesnard C, Parent D, Heenen M, Brancart F, Van Vooren JP, Farber CM, Blankaert D, Werenne J: Kaposi’s sarcoma and herpesvirus 8: A word of caution. Dermatology 1996;193:272.
21.
Bigoni B, Dolcetti R, de Lellis L, Carbone A, Boiocchi M, Cassai E, Di Luca D: Human herpesvirus 8 is present in the lymphoid system of healthy persons and can reactivate in the course of AIDS. J Infect Dis 1996;173:542–549.
22.
Viviano E, Vitale F, Ajello F, Perna AM, Villafrate MR, Bonura F, Arico M, Mazzola G, Romano M: Human herpesvirus type 8 DNA sequences in biological samples of HIV-positive and negative individuals in Sicily. AIDS 1997;11:607–612.
23.
Witte MH, Stuntz M, Witte CL, Way D: AIDS, Kaposi’s sarcoma and the gay population. Int J Dermatol 1989;28:585–586.
24.
Schwartz JJ, Myskowski PL: Molluscum contagiosum in patients with human immunodeficiency infection. J Am Acad Dermatol 1992; 27:583–588.
25.
Simonart T, Van Vooren JP, Noel JC, Liesnard C, Farber CM, Parent D: High prevalence of cutaneous viral infections in AIDS patients with Kaposi’s sarcoma: Insight into the role of human herpesvirus 8? AIDS 1997;11: 824–826.
26.
Quinnan GV, Masur H, Rook AH, Armstrong G, Frederick WR, Epstein J, Manischewitz JF, Marcher AM, Jackson L, Ames J, Smith HA, Parker M, Peakson GR, Parillo J, Mitchell C, Straus SE: Herpesvirus infections in the acquired immune deficiency syndrome. JAMA 1984;252:72–77.
27.
Fiorelli V, Gendelman R, Samaniego F, Markham PD, Ensoli B: Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi’s sarcoma spindle-cells. J Clin Invest 1995;95:1723–1734.
28.
Van Damme J, Schaafsma M, Fibbe W, Falkenburg J, Opdenakker G, Billiau A: Simultaneous production of interleukin 6, interferon-β and colony-stimulating activity by fibroblasts after viral and bacterial infection. Eur J Immunol 1989;19:163.
29.
Nelson JA, Ghazal P, Wiley CA: Role of opportunistic viral infections in AIDS. AIDS 1990;4:1–10.
30.
Heng MC, Heng SY, Allen SG: Co-infection and synergy of human immunodeficiency virus-1 and herpes simplex virus-1. Lancet 1994; 343:255–258.
31.
Henghold WB, Purvis SF, Schaffer J, Leonard DGB, Giam C-Z, Wood GS: Kaposi sarcoma-associated herpesvirus/human herpesvirus type 8 and Epstein-Barr virus in iatrogenic Kaposi sarcoma. Arch Dermatol 1997;133: 109–111.
1998
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